Abstract
Epstein-Barr virus (EBV) has been readily demonstrated to infect human B lymphocytes from tonsils or peripheral blood in vitro and impart to these cells the ability to proliferate indefinitely (1–4). EBV is considered an etiologic agent for infectious mononucleosis worldwide as well as Burkitt’s lymphoma in equitorial Africa and nasopharyngeal carcinoma in China. While the molecular biology of such transformation of B lymphocytes is not yet completely understood, it has been determined that the EBV genome is integrated into the transformed cells (3). Patients with Burkitt’s lymphoma and other EBV associated diseases demonstrate altered immune competence; however, there is little information available concerning the role of the virus in precipitation of these effects (5). In this regard, Werkmeister et al. reported that Daudi cells, which are an EBV transformed cell line, release into their culture fluid a substance capable of inhibiting phytohemagglutinin induced mitogenesis of lymphocytes (6).
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© 1986 Plenum Press, New York
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Zhang, JL., Hsu, L., Specter, S., Friedman, H., Nonoyama, M., Szentivanyi, A. (1986). Depressive Effect of Epstein-Barr Virus Transformed Cell Fractions on Responsiveness of Human Leukocytes to Mitogens. In: Szentivanyi, A., Friedman, H. (eds) Viruses, Immunity, and Immunodeficiency. University of South Florida International Biomedical Symposia Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2185-9_5
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DOI: https://doi.org/10.1007/978-1-4613-2185-9_5
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