Virus Interactions with the Host: Past, Present and Future Developments

  • John J. Trentin
Part of the University of South Florida International Biomedical Symposia Series book series (USFIBSS)


The first demonstration of the oncogenicity of a human virus was the induction of malignant transplantable tumors by injection of human adenovirus Type 12 into newborn hamsters (1), or mice (2). Tumors arose early at any of several sites of injection, and sometimes remotely, usually in the liver, resulting in death from tumor growth in from 29 to 108 days (3). The tumors were histologically undifferentiated malignant neoplasms (4). They contained virus-induced transplantation antigens (5) and newborn hamsters could be passively protected against tumor induction by immunization of the mothers before pregnancy (6).


Acquire Immune Deficiency Syndrome Herpes Virus Adenovirus Type Arterial Smooth Muscle Cell Human Adenovirus 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • John J. Trentin
    • 1
  1. 1.Division of Experimental BiologyBaylor College of MedicineHoustonUSA

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