Can Septal Grafting Facilitate Recovery from Physiological and Behavioral Deficits Produced by Fornix Transections?

  • Menahem Segal
  • Norton W. Milgram
Part of the Advances in Behavioral Biology book series (ABBI, volume 29)


There is now considerable evidence which links the severe memory deficit of dementia of the Alzheimer type (AD) to degeneration of cholinergic basal forebrain neurons and a corresponding reduction in forebrain acetylcholine (ACh) (1–5), The significance of such correlations are strengthened by observations of memory deficits in animals produced by either pharmacological blocking of ACh or by specific brain lesions (6). In spite of this evidence, attempts to alleviate memory deficits in AD patients by pharmacological manipulation of acetylcholine has had only limited success (7). It is consequently of considerable importance to evaluate the feasibility of treating cognitive dysfunctions by other means such as the recently developed procedure of grafting fetal neural tissue into adult hosts (8,9,10). The present studies were undertaken with this purpose in mind. We have been studying the effects of grafted cholinergic neurons on an animal model of AD produced by denervation of the cholinergic input of the hippocampus.


Theta Activity Theta Rhythm Septal Nucleus Septal Tissue Basal Forebrain Neuron 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Menahem Segal
    • 1
  • Norton W. Milgram
    • 1
  1. 1.Center for Neurosciences and Behavioral ResearchWeizmann Institute of ScienceRehovotIsrael

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