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Dysfunction of Central Cholinergic System in Hyperkinetic Rats, Following Postnatal Anoxia

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Alzheimer’s and Parkinson’s Disease

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 29))

Abstract

Rats exposed during the first 24 hours following birth to 100% nitrogen for 25 minutes, demonstrated increased motor activity in the open field between 10–40 days of age (1). At maturity, however, they still displayed deficits in 6-choice discrimination learning (2). Biochemical studies of the brain revealed an increase in the density of muscarinic cholinergic receptors in the hippocampus, which appeared early in life and before any changes in other brain receptors tested could be detected (dopaminergic in caudate and 3 adrenergic in hippocampus). The increased [3H] QNB binding in the hippocampus, demonstrated already at six days of life, reached peak values at 15–20 days, then decreased towards normal values at 40 days of life (2).

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Authors and Affiliations

  1. Department of Physiology and Pharmacology, Tel Aviv University Sackler Faculty of Medicine, Tel Aviv, 69978, Israel

    Zipora Speiser, Chen Sharafan, Simon Gitter, Sasson Cohen, Baruch Gonen & Moshe Rehavi

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  1. Zipora Speiser
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  2. Chen Sharafan
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  3. Simon Gitter
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  4. Sasson Cohen
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  5. Baruch Gonen
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  6. Moshe Rehavi
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Editor information

Editors and Affiliations

  1. Israel Institute for Biological Research, Ness-Ziona, Israel

    Abraham Fisher  & Chaim Lachman  & 

  2. Loyola University Stritch School of Medicine, Chicago, Illinois, USA

    Israel Hanin

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© 1986 Plenum Press, New York

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Speiser, Z., Sharafan, C., Gitter, S., Cohen, S., Gonen, B., Rehavi, M. (1986). Dysfunction of Central Cholinergic System in Hyperkinetic Rats, Following Postnatal Anoxia. In: Fisher, A., Hanin, I., Lachman, C. (eds) Alzheimer’s and Parkinson’s Disease. Advances in Behavioral Biology, vol 29. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2179-8_55

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  • DOI: https://doi.org/10.1007/978-1-4613-2179-8_55

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9283-8

  • Online ISBN: 978-1-4613-2179-8

  • eBook Packages: Springer Book Archive

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