A Review of the Behavioral Effects of AF64A, A Cholinergic Neurotoxin
Acetylcholine (ACh) was the first substance shown to mediate synaptic transmission in the nervous system. Since those early studies the biochemical events involved in the metabolism of ACh and its1 interaction with muscarinic and nicotinic receptors have been studied in great detail. Despite these efforts to unravel the molecular biology of ACh the functional properties of cholinergic systems and their involvement in neurological and psychiatric disorders remain undetermined. During the past five years however, there have been several important advances in our understanding of cholinergic biology. A general principle that has emerged from these efforts is the interdependent nature of discoveries in clinical and basic neuroscience. For example, delineating the structural, neurochemical and behavioral pathology of senile dementia of the Alzheimer’s type (SDAT) contributed to a better understanding of cholinergic involvement in disease states and also provided fundamental information about the anatomical and functional organization of cholinergic neurons.
KeywordsPassive Avoidance Kainic Acid ChAT Activity Its1 Interaction Passive Avoidance Response
Unable to display preview. Download preview PDF.
- 1.E.L. Bailey, D.H. Overstreet and A.D. Crocker. Neurosci. Lett. Suppl. 19: S37 (1985).Google Scholar
- 7.J.T. Coyle, E.D. London, K. Biziere and R. Zaczek. Adv. in Neurology 23:593–608 (1979).Google Scholar
- 9.D.A. Drachman. Neurology 27: 783–790 (1977).Google Scholar
- 11.A. Fisher, C.R. Mantione, E. Grauer, A. Levy and I. Hanin. In: Behavioral Models and the Analysis of Drug Action. M. Y. Speigel-stein and A. Levy (Eds.), Elsevier Scientific Publishing Co., Amsterdam, The Netherlands, 1983, pp. 333–342.Google Scholar
- 15.J.B. Martin. Neurology 34: 1059–1072 (1984)Google Scholar
- 18.P.L. McGeer and E.G. McGeer. CRC Crit, Rev. Toxicol. 1–26 (1982)Google Scholar
- 19.E.K. Perry, B.E.Tomlinson., G. B.essed, K. Bergman, P.H. Gibson and R.H. Perry. Brit. Med. J. 2: 1457–1459 (1978).Google Scholar
- 21.D.L. Price, P.J. Whitehouse, R.G. Struble, A.W. Clark, J.T. Coyle, M.R. DeLong and J.C. Hedreen. Neurosci. Commentaries 1: 84–92 (1982)Google Scholar
- 22.R.J. Rylett, M.J. Ball and E.H. Colhoun. Brain Res. (1983).Google Scholar
- 28.T.J. Walsh, D.L. DeHaven, R.B. Mailman, A. Fisher and I. Hanin. Soc. Neurosci. Abstr. Vol 10, 257 1984.Google Scholar