Abstract
Cyclic AMP, the so-called “second messenger” mediates the effects of a number of hormones including catecholamines on a plethora of cell processes (1). The hormone-stimulated adenylate cyclase complex consists of three principal components. The receptor spans the plasma membrane and its external side provides a site for binding circulating hormones. The Ns and Ni proteins, or guanine-nucleotide binding regulatory subunits, link the receptor to the catalytic subunit of the enzyme. Ihe activated or inhibited (in the case of Ni coupling) catalytic subunit converts ATP to cyclic AMP. The various components of the hormone-sensitive adenylate cyclase complex can to sane extent be separately measured and a number of studies have demonstrated the functional independence of these subunits (2).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
E.W. Sutherland, I. Oye, and R.W. Butcher, Ree. Prog. Hormone Res, 21: 623 (1965).
G.L. Giles, M.G. Caron and R.J. Lefkowitz, Physiol. Rev. 64: 661 (1984)
J. Stessman, R. Eliakim, C. Cahan, and R.P. Ebstein, J. Gerontol. 39: 667 (1984).
J. Stessman, R. Eliakim, and R.P. Ebstein, Age, 7: 71 (1984).
M. Newman, E. Klein, B. Birmaher, M. Feinsod, and R.H. Belmaker, Brain Res. 278: 380 (1983).
D. Seiinger, D. Waksman, J. Stessman, and R.P. Ebstein, Salbutamol- induced rise in cyclic AMP and amylase levels in human parotid secretion, submitted.
R.P. Ebstein, J.Biederman, R. Rimon, J. Zohar, and R.H. Belmaker, Psychopharmacol. 51: 71 (1976).
R.P. Ebstein, G. Oppenheim, and J. Stessman, Life Sei. 34: 2239 (1984).
Oppenheim, G., J. Mintzer, I. Halperin, R. Eliakim, J. Stessman and R.P. Ebstein, Life Sei. 35: 1795 (1984).
R.P. Ebstein, G. Oppenheim, M.S. Tropper, A. Yagur, and J. Stessman, Clin. Neuropharmacol. 7 (Suppl.l): S23 (1984).
N.S. Nadi, J.I. Nürnberger, Jr., and E.S. Gershon, New Engl. J. Med. 311: 225 (1984).
R.P. Ebstein, M. Steinitz, J. Mintzer, J., I. Lipshitz, and J. Stessman, Beta-adrenergic stimulated adenylate cyclase activity in normal and EBV-transformed lymphocytes, submitted.
J. Mintzer, O. Brawman, I. Lipshitz, Z. Shemesh, J. Stessman, and R.P. Ebstein, Hormone and forskolin-stimulated cyclic AMP accumulation in human lymphocytes: Reliability of longitudinal measurements, submitted.
R.P. Ebstein, J. Mintzer, Y. Lipschitz, Z. Shemesh, L.R. Goldin, and J. Stessman, Heritability of forskolin and hormone-stimulated adenylate cyclase activity in human lymphocytes, submitted.
R.P. Ebstein, 0. Brawman, J. Mintzer, B.S. Ebstein and J. Stessman, Hormone-stimulated cyclic AMP synthesis in human lymphocytes during the menstrual cycle, submitted.
J.H. Ball, N.I. Kaminsky, J.G. Hardman, A.E. Broadus, E.W. Sutherland, and G.W. Liddle, J. Clin. Invest. 51: 2124 (1972).
R.P. Ebstein, T. Kara, and R.H. Belmaker, Acta Pharmacol. Toxicol. 41: 80 (1977).
I.D. Mandel and R.L. Katz, J. Oral Ther. Pharmacol. 4: 260 (1968).
D. Selinger, D.J. Cohen, S. Ort, G.M. Anderson, K.A. Caruso and J.F. Leckman, J. Am. Acad. Child Psychiatry, 23: 392 (1984).
C.S. Henney, H.R. Bourne, and L.M. Lichtenstein, J. Immunol. 108: 1526 (1972).
R.L. Walford, J. Gerontol. 17: 281 (1962).
D. Cohen and C. Eisdorfer, Br. J. Psychiat. 136: 33 (1980).
J.F. Krall, M. Connelly, and M.L. Tuck, J. Pharmacol. Exp. Ther. 214: 554 (1980).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Ebstein, R.P. et al. (1986). Hormone-Stimulated Adenylate Cyclase Activity In Man: Studies With Peripheral Models. In: Fisher, A., Hanin, I., Lachman, C. (eds) Alzheimer’s and Parkinson’s Disease. Advances in Behavioral Biology, vol 29. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2179-8_44
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2179-8_44
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9283-8
Online ISBN: 978-1-4613-2179-8
eBook Packages: Springer Book Archive