Skip to main content

Measles Virus Infection of Human Neural Cell Lines as a Model for Persistent Viral Infection of the Central Nervous System

  • Chapter
Alzheimer’s and Parkinson’s Disease

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 29))

  • 145 Accesses

Abstract

Measles virus is a ubiquitous human pathogen member of the genus morbillivirus. Acute measles caused by the virus is commonly regarded as a childhood self limited and relatively innocuous disease. However, serious parainfectious complications of measles may occur. In about 1 in 1000 cases, acute encephalomyelitis with perivascular inflammatory and demyelinating damage, may lead to death in 10-20% of patients.1 At least one third of the affected are left with major neurological residua, such as recurrent seizures, mental retardation, hyperkinesis and perceptual disorders.2 In spite of the wide use of live attenuated measles virus vaccine, this exanthem is still a major public health problem.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. K.P. Johnson, J.S. Wolinsky and A.H. Ginsberg, Immune mediated syndromes of the nervous system related to virus infections. In: Handbook of Clinical Neurology, P.J. Vinken and G.W. Bruyn, ed. Vol. 34, Elsevier-North Holland, Amsterdam (1978).

    Google Scholar 

  2. J.H. Menkes, In: Textbook of child neurology. 2 Edition. Lea and Feibiger, Philadelphia (1980).

    Google Scholar 

  3. H.E. Gendelman, J.S. Wolinsky, R.T. Johnson, N.J. Pressman, G.H. Pezeshkpour and G.F. Boisset, Measles encephalomyelitis: Lack of evidence of viral invasion of the central nervous system and quantitative study of the nature of demyelination. Ann. Neurol., 15: 354 (1984).

    Article  Google Scholar 

  4. F.E. Payne, J.V. Baublis and H.H. Itabashi, Isolation of measles virus from cell cultures of brain from a patient with subacute sclerosing panecephalitis. New Engl. J. Med., 281: 585 (1969).

    Article  PubMed  CAS  Google Scholar 

  5. A.T. Haase, P. Ventura, C. J. Gibbs,Jr. and W.W. Tourtellotte. Measles virus nucleotide sequences: Detection by hybridization in-situ. Science, 212: 672 (1981).

    Article  PubMed  CAS  Google Scholar 

  6. V. ter Meulen and W.W. Hall, Slow virus infections of the nervous system: Virological, immunological and pathogenic considerations. J. Gen. Virol, 41: 1 (1978).

    Article  PubMed  Google Scholar 

  7. B. Rager-Zisman, J.E. Egan, Y. Kress and B.R. Bloom, Isolation of cold sensitive mutants of measles virus from persistently infected murine neuroblastoma cells. J. Virol., In Press (1985).

    Google Scholar 

  8. M.J. Birrer, S. Udem, S. Nathenson and B.R. Bloom, Antigenic variants of measles virus. Nature, 293: 67 (1981).

    Article  PubMed  CAS  Google Scholar 

  9. M.J. Birrer, B.R. Bloom and S. Udem, Characterization of measles polypeptides by monoclonal antibodies. Virology 108: 381 (1981).

    Article  PubMed  CAS  Google Scholar 

  10. E. Norrby, S.N. Chen, T.Togashi, H.Shesberadaran and K.P. Johnson, Five measles virus antigens demonstrated by use of mouse hybridoma antibodies in productively infected tissue culture cells. Arch. Virol, 71: 1 (1982).

    Article  PubMed  CAS  Google Scholar 

  11. R.C. Seeger, Y.L. Danon, P.M. Zeltzer, Y.E. Maidman and S.A. Rayner, Expression of fetal antigens by human neuroblastoma cells. Prog. Cancer Res. Therapy, 12: 199 (1980).

    Google Scholar 

  12. B. Rager-Zisman and T.C. Merigan, A useful quantitative semimicromethod for viral pluques assay. Proc.Soc.Exp.Biol.Med., 142: 1174 (1973).

    PubMed  CAS  Google Scholar 

  13. M. Nowakowski, J.D. Feldman, S. Kano and B.R. Bloom, The production of vesicular stomatitis virus by antigen or mitogen stimulated lymphocytes and continuous lymphoblastoid lines. J. Exp. Med., 137: 1042 (1973).

    Article  PubMed  CAS  Google Scholar 

  14. M. Sakaguchi, Y. Yoshikawa and K. Jamshouchi, Growth of measles and subacute sclerosing panencephalitis viruses in human neural cell lines. Microbiol. Immunol., 28: 461 (1984).

    PubMed  CAS  Google Scholar 

  15. W.W. Hall, R.A. Lamp and P.W. Choppin, Measles and subacute sclerosing panencephalitis virus proteins: Lack of antibodies to the M protein in patients with subacute sclerosing panencephalitis. Proc. Natl. Acad. Sei. USA, 76: 2047 (1979).

    Article  CAS  Google Scholar 

  16. R.T. Johnson, The possible viral etiology of multiple sclerosis. Adv. Neurol, 13: 1 (1975).

    PubMed  CAS  Google Scholar 

  17. W. Hall,R. Lamp and P.W. Choppin, Measles virus proteins in the brain tissue of patients with subacute sclerosing panencephalitis:Absence of the M protein. New Engl. J. Med., 12: 690 (1981).

    Google Scholar 

  18. G. J. Atkins and B.J. Sheahan, Semliki forest virus neurovirulence mutants have altered cytopathogenicity for central nervous system cells. Infect. Immunity, 36: 333 (1982).

    CAS  Google Scholar 

  19. J.L. Biedler,R.A. Ross,S. Shanske,B. Spengler and A.E. Evans, Human neuroblastoma cytogenetics. Proc.Cancer Res.Therapy, 12: 81 (1980)

    Google Scholar 

  20. R.A. Ross,J.L. Biedler,B.A. Sprengler and D. Reis, Neurotransmitter enzymes in human neuroblastoma cell lines. Cell. Med. Neurobiol., 1: 301 (1981).

    Article  Google Scholar 

  21. G.J. West, J. Uki, H.R. Herschman and R.C. Seeger, Adrenergic cholinergic and inactive human neuroblastoma cell lines with the action potential Na ionophore. Cancer Res, 37: 1372 (1977).

    PubMed  CAS  Google Scholar 

  22. L.J. Whalley: F. Marott Sinex, C.M. Merril (Eds). Alzheimer’s disease, Down syndrome, and aging. New York, Acad. Sei, New-York (1982).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Plenum Press, New York

About this chapter

Cite this chapter

Danon, Y.L., Rager-Zisman, B., Garty, B., Gadoth, N. (1986). Measles Virus Infection of Human Neural Cell Lines as a Model for Persistent Viral Infection of the Central Nervous System. In: Fisher, A., Hanin, I., Lachman, C. (eds) Alzheimer’s and Parkinson’s Disease. Advances in Behavioral Biology, vol 29. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2179-8_32

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2179-8_32

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9283-8

  • Online ISBN: 978-1-4613-2179-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics