Quantitative Autoradiography and Histochemistry in the Human Brain Post Mortem
The cholinergic system has been repeatedly implicated in diseases involving loss of memory and cognitive function.1 It is also evident that disease or aging may affect some discrete nuclei in the brain and spare others.1 In the following pages we will describe the adaptation of two classical morphological methods - histochemistry and autoradiography - for quantitative measurement of cholinergic elements in the human brain post mortem. This new methodology will make it feasible to perform quantitative but anatomically discrete comparisons between normal brains and brains of patients with senile dementia and related diseases.
KeywordsFormalin Dementia Glycine Iodide Neurol
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