Quantitative Autoradiography and Histochemistry in the Human Brain Post Mortem
The cholinergic system has been repeatedly implicated in diseases involving loss of memory and cognitive function.1 It is also evident that disease or aging may affect some discrete nuclei in the brain and spare others.1 In the following pages we will describe the adaptation of two classical morphological methods - histochemistry and autoradiography - for quantitative measurement of cholinergic elements in the human brain post mortem. This new methodology will make it feasible to perform quantitative but anatomically discrete comparisons between normal brains and brains of patients with senile dementia and related diseases.
KeywordsMuscarinic Receptor Cholinergic System Acetylthiocholine Iodide Quantitative Autoradiography Ache Content
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- 1.Bowen, D.M., Davison, A.N. and Sims, N.R. (1983). The cholinergic system in aging brain and dementia. In: Aging of the Brain, Samuel et al., ed. Raven Press, N.Y., p. 183–195.Google Scholar
- 7.Greenfield, S. (1984). Acetylcholinesterase may have novel functions in the brain. TINS 10, 364–368.Google Scholar