Quantitative Autoradiography and Histochemistry in the Human Brain Post Mortem

  • Anat Biegon
  • Marilyn Wolff
Part of the Advances in Behavioral Biology book series (ABBI, volume 29)


The cholinergic system has been repeatedly implicated in diseases involving loss of memory and cognitive function.1 It is also evident that disease or aging may affect some discrete nuclei in the brain and spare others.1 In the following pages we will describe the adaptation of two classical morphological methods - histochemistry and autoradiography - for quantitative measurement of cholinergic elements in the human brain post mortem. This new methodology will make it feasible to perform quantitative but anatomically discrete comparisons between normal brains and brains of patients with senile dementia and related diseases.


Muscarinic Receptor Cholinergic System Acetylthiocholine Iodide Quantitative Autoradiography Ache Content 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Anat Biegon
    • 1
  • Marilyn Wolff
    • 1
  1. 1.Isotope DepartmentThe Weizmann Institute of ScienceRehovotIsrael

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