Abstract
The chemically modified materials arising from natural tissue or organs sometimes show excellent blood-compatibility and can be utilized in reconstructive surgery. Hundreds of glutaraldehyde-treated human umbilical cord vessels (GA.UCV) have been implanted in humans as an artificial blood vessel and acetylated bovine pericardium (AC.PC) appears to be very promising as a material for the substitution of bladder tissue. (1–3). Both GA.UCV and AC.PC are well known to be composed of collagen, polysaccharide and lipid, and their surfaces are comparatively hydrophobic. In spite of the successful utilization of these materials in therapeutic reconstructive surgery, the characteristics and functional properties of these conjugated materials still remain to be clarified, mainly because of their complicated chemical and physical structures. An examination of model compounds simulating the GA.UCV or AC.PC surfaces chemically, should provide some understanding of this. (4–6). Accordingly, we prepared acylated chitins with various lengths of acyl groups in side chain hydroxy groups as model compounds simulating lipid polysaccharide conjugates and investigated their practical use as materials for blood contacting surfaces. (7). In this study, we have attempted to elucidate the relationship between the various types of acylated chitin and the thrombo-resistant properties and wetting characteristics of the respective materials.
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References
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© 1986 Plenum Press, New York
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Komai, T., Kaifu, K., Matsushita, M., Koshino, I., Kon, T. (1986). Biomedical Evaluation of Acylated Chitins as Coating Materials. In: Muzzarelli, R., Jeuniaux, C., Gooday, G.W. (eds) Chitin in Nature and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2167-5_59
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DOI: https://doi.org/10.1007/978-1-4613-2167-5_59
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