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Chitosan Effect in Vascular Surgery, Tissue Culture and Tissue Regeneration

  • W. G. Malette
  • H. J. QuigleyJr.
  • E. D. Adickes

Abstract

In our previous studies of hemostasis utilizing Chitosan solution (2 mgm/ml.pH4)1,2 we found that the Chitosan solution formed a coagulum in contact with whole blood. No such reaction was obtained with albumen, globulin, white cells, or platelets. Further investigation showed that the reaction did occur with heparinized blood, defibrinated blood, washed red cells and pure red cell membranes. Therefore, the mechanism for the coagulation appears to be a reaction between the red cell membrane and the Chitosan solution leading to crosslinkage or re-polymerization. (Fig 1)

Keywords

Myocardial Cell Chitosan Solution Marrow Cavity Tissue Culture Method Myelinated Nerve Fiber 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    W. G. Malette, H. J. Quigley, Jr., R. D. Gaines, N. D. Johnson, and W. G. Rainer: Chitosan, A New Hemostatic, Ann Th Surg. 36: 55 (1983)CrossRefGoogle Scholar
  2. 2.
    G. Brandenberg, L. G. Leibrock, R. Shuman, W. G. Malette, and H. J. Quigley Jr.: Chitosan, A New Hemostatic Agent for Diffuse Capillary Bleeding in Brain Tissue, Neurosurgery: 15: 9 (1984)PubMedCrossRefGoogle Scholar
  3. 3.
    D. Yaffe, Rat Skeletal Muscle Cells, in Tissue Culture, Methods and Applications, (Kruse and Patterson eds) Academic Press. (1972)Google Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • W. G. Malette
    • 1
  • H. J. QuigleyJr.
    • 1
  • E. D. Adickes
    • 1
  1. 1.Veterans Administration Medical CenterOmahaUSA

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