Chitosan Effect in Vascular Surgery, Tissue Culture and Tissue Regeneration
In our previous studies of hemostasis utilizing Chitosan solution (2 mgm/ml.pH4)1,2 we found that the Chitosan solution formed a coagulum in contact with whole blood. No such reaction was obtained with albumen, globulin, white cells, or platelets. Further investigation showed that the reaction did occur with heparinized blood, defibrinated blood, washed red cells and pure red cell membranes. Therefore, the mechanism for the coagulation appears to be a reaction between the red cell membrane and the Chitosan solution leading to crosslinkage or re-polymerization. (Fig 1)
KeywordsChitosan Heparin Sponge Chitin Ghost
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