Abstract
Fractionation of hematoporphyrin derivative by chromatography has been performed by several methods such as TLC, HPLC and gel exclusion (Dougherty, 1983; Dougherty et al., 1983; Grossweiner et al., 1983; Kessel, 1983; Evensen et al., 1984). The pattern, number and nature of the fractions depend obviously on the method of separation. Yet, common to all methods, not all fractions retain the ability of the drug to act as a photodynamic agent for tumor treatment and there are also indications that the active and nonactive fractions differ in terms of aggregation (Dougherty et al., 1983; Kessel, 1984; Evensen et al., 1984).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abraham, R.J., P.A. Burbridge, A.H. Jackson and D.B. Macdonald (1966) J. Chem. Soc. B, 620–626.
Abraham, R.J., F. Eivazi, H. Pearson and K.G. Smith (1976) J. Chem. Soc. Commun., 698–701.
Brown, S.B., H. Hätzikonstantinou and D.G. Herries (1980) Int. J. Biochem. 12, 701–707.
Brown, S.B., M. Schillcock and P. Jones (1976) Biochem. J. 153, 279–285.
Cohen, S. and R. Margalit (1985) Biochim. Biophys. Acta 813, 307–312.
Dougherty, T.J. (1983) Photochem. Photobiol. 38, 377–379.
Dougherty, T.J., D.G. Boyle, K.R. Weishaupt, B.A. Henderson, W.R. Potter, D.A. Bellnier and K.E. Wityk (1983) Porphyrin Photosensitization (Kessel, D. and T.J. Dougherty, eds.), pp. 3 - 13, Plenum Press, New York.
Evensen, F.J., S. Sommer, J. Moan and T. Christensen (1984) Cancer Research 44, 482–486.
Grossweiner, L.I. and G.C. Goyal (1983) Photochem. Photobiol. 37, 529–532.
Janson, T.R. and J.J. Katz (1972) J. Magn. Reson. 6, 209–220.
Kauzmann, W. (1959) Adv. Protein Chem. 14, 1–63.
Kessel, D. (1977) Biochemistry 16, 3443–3449.
Kessel, D. (1984) Photochem. Photobiol. 40, 851–859.
Kessel, D. and T.-H Chou (1983) Cancer Research 43, 1994–1999.
Kessel, D. and E. Rossi (1982) Photochem. Photobiol. 35, 37–41.
Margalit, R. and S. Cohen (1983) Biochem. Biophys. Acta 736, 163–170.
Margalit, R. and Rotenberg, M. (1984) Biochem. J. 219, 445–450.
Margalit, R., N. Shaklai and C. Cohen (1983) Biochem. J. 209, 547–552.
Nemethy, G. and H.A. Scheraga (1962) J. Chem. Phys. 36, 3401–3417.
Oku, N., D.A. Kendall and R.C. MacDonald (1982) Biochim. Biophys. Acta 692, 384–388.
Paterson, Y., G. Nemethy and H.A. Scheraga (1981) Ann. N.Y. Acad. Sei. 367, 132–150.
Sinanoglu, O. (1968) Molecular Associations in Biology (Pullman, B., ed.), pp. 427–445, Academic Press, New York.
Sinanoglu, O. (1981). Int. J. Quant. Chem. 18, 381–392.
Sinanoglu, O. and S. Abdulnur (1965) Fed. Proc. Fed. Am. Soc. Expl. Biol. 14, Suppl. III, 512–523.
Szoka, F.C. and D. Papahadjoupoulos (1980) Ann. Rev. Bioenerg. 9, 467–508.
Tanford, C. (1973) The Hydrophobic Effect, John Wiley and Sons, New York.
Zlatkis, A. and B. Zak (1968) Anal. Biochem. 29, 143.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Plenum Press, New York
About this chapter
Cite this chapter
Margalit, R., Cohen, S., Rotenberg, M. (1985). Studies on the Solvophobic Nature of Porphyrin Self Aggregation vs. the Lipophylic Nature of Porphyrin-Membrane Binding. In: Kessel, D. (eds) Methods in Porphyrin Photosensitization. Advances in Experimental Medicine and Biology, vol 193. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2165-1_29
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2165-1_29
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9276-0
Online ISBN: 978-1-4613-2165-1
eBook Packages: Springer Book Archive