Abstract
Neurofibrillary changes are pathological hallmarks of a variety of neurotoxic and degenerative disorders. Progress during the last five years in reconstructing the pathogenesis of neurofibrillary changes has resulted from correlations of ultrastructural findings with aberrations in the axonal transport of neurofilament proteins. The first neurotoxic agent studied in this fashion was β,β’-iminodipropionitrile (IDPN) (Griffin et al., 1978). Recently, comparable studies have become available on aluminum (Troncoso et al., 1983; Bizzi et al., 1984; Parhad et al., 1984), colchicine (Komiya and Kurokawa, 1980), 3,4-dimethyl-2,5-hexanedione (DMHD) (Griffin et al., 1984), acrylamide (Sidenius and Jakobsen, 1983; Gold et al., 1985), and 2,5- hexanedione (Gold, Griffin, Price, unpublished observation).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Gold, B. G., Griffin, J. W. and Price, D. L., 1985, Slow axoplasmic transport in acrylamide neuropathy: different abnormalities produced by single-dose and continuous administration, J. Neurosci., (in press).
Griffin, J. W., Hoffman, P.N., Clark, A. W., Carroll, P.T. and Price, D. L., 1978, Slow axonal transport of neurofilament proteins: impairment by β,β’-iminodipropionitrile administration, Science, 202: 633–635.
Hoffman, P. N. and Lasek, R. J., 1980, Axonal transport of the cytoskeleton in regenerating motor neurons: constancy and change, Brain Res., 202: 317–333.
Komiya, Y. and Kurokowa, M., 1980, Preferential blockade of the tubulin transport by colchicine, Brain Res. 190: 505–516.
Lasek, R. J. and Hoffman, P. N., 1976, The neuronal cytoskeleton, axonal transport and axonal growth, Cold Spring Harbor Conferences on Cell Proliferation 3: 1021–1049.
Parhad, I. M., Griffin, J. W. and Koves, J. F., 1984, Aluminum intoxication in the visual system: Morphological and axonal transport studies, Neurology, 34 (Suppl 1): 197.
Roots, B. I., 1983, Neurofilament accumulation induced in synapses by leupeptin, Science, 221: 971–972.
Stanley, E. F., Hoffman, P. N., Griffin, J. W. and Price, D. L., 1984, Effect of axotomy on conduction in the proximal motor nerve, Neurology, 34 (Suppl 1): 182.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Gold, B.G., Griffin, J.W., Price, D.L., Hoffman, P.N. (1986). Primary and Secondary Changes in Axonal Transport in Neurofibrillary Disorders. In: Clarkson, T.W., Sager, P.R., Syversen, T.L.M. (eds) The Cytoskeleton. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2161-3_8
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2161-3_8
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9274-6
Online ISBN: 978-1-4613-2161-3
eBook Packages: Springer Book Archive