Advertisement

Medical Treatment of Infertility

  • Wayne Decker

Abstract

Ovulation defects are a major cause of infertility. It was not until about 20 years ago that pharmacologic means became available to induce ovulation consistently in the anovulatory woman. The first of these drugs to become available for general clinical use was clomiphene citrate, which remains the safest, the most broadly effective, and the most widely used of several agents now available.

Keywords

Luteinizing Hormone Pituitary Adenoma Prolactin Level Estradiol Level Premature Ovarian Failure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Stahler E, Strum G, Dawme E: Direktwirkung von Clomiphen auf das Ovar. Untersucht am In Vitro Perfundierten Menschlichen Ovar. Arch Gynak 219: 585, 1975CrossRefGoogle Scholar
  2. 2.
    Garcia J, Jones GS, Wentz AC: The use of clomiphene citrate. Fertil Steril 28: 707, 1977PubMedGoogle Scholar
  3. 3.
    Lobo RA, Gysier M, March CM, et al: Clinical and laboratory predictors of clomiphene response. Fertil Steril 37: 168, 1982PubMedGoogle Scholar
  4. 4.
    Gorlitsky G, Kase NG, Speroff L: Ovulation and pregnancy rate with clomiphene citrate. Obstet Gynecol 51: 265, 1978PubMedCrossRefGoogle Scholar
  5. 5.
    March CM, Tredway DR, Mishel, DR Jr: Effect of clomiphene citrate upon amount and duration of human menopausal gonadotropin therapy. Am J Obstet Gynecol 125: 699, 1976PubMedGoogle Scholar
  6. 6.
    Campbell H J, Feurer G, Garcia J, et al: The infusion of brain extracts into the anterior pituitary gland and the secretion of gonadotrophs hormone. J Physiol (Lond) 157: 1661, 1960Google Scholar
  7. 7.
    McCann SM, Talesnik S, Friedman H: LH releasing activity in hypothalamic extracts. Proc Soc Exp Biol Med 104: 432, 1960Google Scholar
  8. 8.
    Matsuao H, Baba Y, Nair RMG, et al: Structure of the porcine LH and FSH releasing factor. Biochem Biophys Res Commun 43: 1334, 1971CrossRefGoogle Scholar
  9. 9.
    Birgus R, Butcher M, Ling N, et al: Structure du moléculaire du facteur hypothalamique (LRF) et l’origine ovine contrôlant la secretion de l’hormone gonadotrope hypophysäre de luteinisation (LH). CR Acad Sci (D) (Paris) 273: 1611, 1971Google Scholar
  10. 10.
    Taymor ML: The use of luteinizing hormone-releasing hormone in Gynecology. Obstet Gynecol Ann 7: 285, 1978Google Scholar
  11. 11.
    Liu JH, Durfee R, Muse K, et al: Induction of multiple ovulation by pulsatile administration of gonadotropin-releasing hormone. Fertil Steril 40: 18, 1983PubMedGoogle Scholar
  12. 12.
    Keye WR Jr, Chang RJ, Monroe SE, et al: Prolactin secreting adenomas in women II. Menstrual function, pituitary reserve and prolactin production following micro surgical removal. Am J Obstet Gynecol 134: 360, 1979PubMedGoogle Scholar
  13. 13.
    Wiebe RH, Kramer RS, Hammond CB: Surgical treatment of prolactin-secreting micro adenomas. Am J Obstet Gynecol 134: 49, 1979PubMedGoogle Scholar
  14. 14.
    Domingue JN, Richmond IL, Wilson CB: Results of surgery in 114 patients with prolactin-secreting pituitary adenomas. Am J Obstet Gynecol 137: 102, 1980PubMedGoogle Scholar
  15. 15.
    McGregor AM, Scanlon MF, Hall R, et al: Effects of bromocriptine on pituitary size. Br Med J 2: 700, 1979PubMedCrossRefGoogle Scholar
  16. 16.
    Corenblum B: Successful outcome of ergocriptine-induced pregnancies in twenty-one women with prolactin-secreting pituitary adenomas. Fertil Steril 32: 183, 1979PubMedGoogle Scholar
  17. 17.
    Hancock KW, Lamb JT, Gibson RM, et al: Conservative management of pituitary prolactinomas: Evidence of bromocriptine-induced regression. Br J Obstet Gynaecol 87: 523, 1980PubMedCrossRefGoogle Scholar
  18. 18.
    Bergh T, Nillius S J, Wide L: Clinical course and outcome of pregnancies in amenorrhoeic women with hyperprolactinaemia and pituitary tumours. Br Med J 1: 875, 1978PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1987

Authors and Affiliations

  • Wayne Decker
    • 1
  1. 1.Fertility Research FoundationNew YorkUSA

Personalised recommendations