Abstract
Colon cancer is a major health problem. It is the second most prevalent organ-site cancer for both sexes in “Western societies”(35) (in the U. S. and Western Europe women get more breast cancer and men get more lung cancer than colon cancer). In the U. S. over 100,000 cases of colon cancer can be expected each year in the 1980s, and about 45% of the cases will be fatal.(19) The incidence of the disease in the U. S. appears to have stabilized since the 1930s. It is slowly increasing among white males and slowly decreasing among white females.(3) About 3% of the population will be affected some time during their lives. As the population of the U. S. shifts to larger proportions of older people, the number of colon cancer cases will steadily increase, and the many adverse effects of this disease on our society will multiply.
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References
B. Armstrong and R. Doll, Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices,Int. J. Cancer 15, 617–631 (1975).
W. R. Bruce, A. J. Varghese, P. C. Land, and J. J. F. Krepinsky, Properties of a mutagen isolated from feces, in:Banbury Report 7,Gastrointestinal Cancer: Endogenous Factors (W. R. Bruce, P. Correa, M. Lipkin, S. R. Tannenbaum, and T. D. Wilkins, eds.), pp. 227–234, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York (1981).
F. Burbank, Patterns in cancer mortality in the United States,Natl. Cancer Inst. Monogr. 33, 1950–1967 (1971).
P. Dion and W. R. Bruce, Mutagenicity of different fractions of extracts of human feces,Mutat. Res. 119, 151–160 (1983).
R. Doll and R. Peto, The causes of cancer: Quantitative estimates of avoidable risks of cancer in the United States today,J. Natl. Cancer Inst. 66, 1193–1308 (1981).
M. Ehrich, J. E. Aswell, R. L. Van Tassell, A. R. P. Walker, N. J. Richardson, and T. D. Wilkins, Mutagens in the feces of 3 South African populations at different levels of risk for colon cancer,Mutat. Res. 64, 231–240 (1979).
I. Gupta, J. Baptista, W. R. Bruce, C. T. Che, R. Furrer, J. S. Gingerish, A. A. Grey, L. Marai, P. Yates, and J. J. Krepinsky, Structures of fecapentaenes, the mutagens of bacterial origin isolated from human feces,Biochemistry 22, 241–245 (1983).
H. Hayatsu, personal communication.
H. Hayatsu, S. Arimoto, K. Togawa, and M. Makita, Inhibitory effect of the ether extract of human feces on activities of mutagens; inhibition by oleic and linoleic acids,Mutat. Res. 36, 287–293 (1981).
M.J. Hill, B. S. Drasar, R. E. O. Williams, T. W. Meade, A. G. Cox, J. E. P. Simpson, and B. C. Morson, Fecal bile acids and Clostridia in patients with cancer of the large bowel,Lancet 1, 535–538 (1975).
D. Ichinotsubo, J. Setliff, H. F. Mower, and M. Mandel, The use ofrec − bacteria for testing of carcinogenic substances,Mutat. Res. 46, 53–62 (1977).
U. Kuhnlein, D. Bergstrom, and H. Kuhnlein, Mutagens in feces from vegetarians and non–vegetarians,Mutat. Res. 85, 1–12 (1981).
H. Kuhnlein, U. Kuhnlein, and P. A. Bell, The effect of short-term dietary modification on human fecal mutagenic activity,Mutat. Res. 113, 1–12 (1983).
I. P. Law, R. B. Herberman, and R. K. Oldham, Familial occurrence of colon and uterine carcinoma and of lymphoproliferative malignancies, clinical description,Cancer 39, 1224–1228 (1977).
M. Lipkin, P. Sherlock, and J. J. De Cosse, Identification of risk factors and preventive measures in the control of cancer of the large intestine,Curr. Problems Cancer 4, 4– 57 (1980).
J. L. Lyon, J. Gardner, M. R. Klauber, and C. R. Smart, Cancer incidence in Mormons and non-Mormons in Utah 1966–1970,N. Engl. J. Med. 294, 129–133 (1976).
T. H. Maugh, Potent mutagen from human feces identified,Science 218, 363 (1982).
H. F. Mower, D. Ichinotsubo, L. W. Wang, M. Mandel, G. Stemmermann, A. Nomura, L. Heilbrun, S. Kamiyama, and A. Schimada, Fecal mutagens in two Japanese populations with different colon cancer risks,Cancer Res.42, 1164–1169 (1982).
M. H. Myers and B. F. Hanky, Cancer patient survival in the United States, in:Cancer Epidemiology and Prevention (D. Schottenfeld and J. F. Fraumeni, eds), pp. 166–178, Saunders, Philadelphia, Pennsylvania (1982).
T. Narisawa, N. E. Magadia, J. H. Weisburger, and E. L. Wynder, Promoting effect of bile acid on colon carcinogenesis after intrarectal installations ofN-methyl-N’-nitro-N-nitrosoguanidine in rats,J. Natl. Cancer Inst. 53, 1093–1097 (1974).
P. Newmark, Still more about oncogenes,Nature 301, 111 (1983).
R. L. Phillips, Role of life-style and dietary habits in risk of cancer among Seventh-Day Adventists,Cancer Res.35, 3403–3406 (1975).
B. S. Reddy, C. Sharma, L. Darby, K. Laakso, and E. L. Wynder, Metabolic epidemiology of large bowel cancer; fecal mutagens in high and low-risk populations for colon cancer,Mutat. Res. 12, 511–522 (1980).
E. P. Reddy, R. K. Reynolds, E. Santos, and M. Barbaad, A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene,Nature 300, 149–152 (1982).
C. A. Rubio, G. Nylander, and M. Santos, Experimental colon cancer in the absence of intestinal contents in Sprague-Dawley rats,J. Natl. Cancer Inst. 64, 569–571 (1980).
P. D. Sorbie and N. Feinleib, The serum cholesterol-cancer relationship: An analysis of time trends in the Framingham study,J. Natl. Cancer Inst. 69, 689–696 (1982).
G. N. Stemmermann, A. M. Y. Nomura, L. K. Heilbrun, E. S. Pollack, and A. Kagan, Serum cholesterol and colon cancer incidence in Hawaiian Japanese men,J. Natl. Cancer Inst. 61, 1179–1182 (1981).
H. F. Stich and U. Kuhnlein, Chromosome breaking activity of human feces and its enhancement by transition metals,Int. J. Cancer 24, 284–287 (1979).
H. F. Stich, W. Stich, and A. B. Acton, Mutagenicity of fecal extracts from carnivorous and herbivorous animals,Mutat. Res. 18, 105–112 (1980).
C. J. Tabin, S. M. Bradley, C. I. Bargmann, R. A. Weinberg, A. G. Papageorge, E. M. Scolnick, R. Dahr, D. R. Lowy, and E. H. Chang, Mechanism of activation of a human oncogene,Nature 300, 143–149 (1982).
S. Venitt, Mutagens in human faeces: Are they relevant to cancer of the large bowel?,Mutat. Res. 98, 265–286 (1982).
J. Waterhouse, C. Muir, and P. Correa, Eds.,Cancer Incidence in Five Continents, Vol. Ill, IARC Scientific Publications No. 15, International Agency for Research on Cancer, Lyon, France (1976).
T. D. Wilkins, M. Lederman, and R. L. Van Tassell, Isolation of a mutagen produced in the human colon by bacterial action, in:Banbury Report 7,Gastrointestinal Cancer: Endogenous Factors (W. R. Bruce, P. Correa, M. Lipkin, S. R. Tannenbaum, and T. D. Wilkins, eds.), pp. 205–212, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York (1981).
T. D. Wilkins, M. Lederman, R. L. Van Tassell, D. G. I. Kingston, and J. Henion, Characterization of a mutagenic bacterial product in human feces,Am. J. Clin. Nutr. 33, 2513–2520 (1980).
J. L. Young and E. S. Pollack, The incidence of cancer in the United States, in:Cancer Epidemiology and Prevention (D. Schottenfeld and J. F. Fraumeni, eds.), pp. 138–165, Saunders, Philadelphia, Pennsylvania (1982).
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Mower, H.F. (1984). The Detection of Mutagens in Human Feces as an Approach to the Discovery of Causes of Colon Cancer. In: de Serres, F.J. (eds) Chemical Mutagens. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2147-7_10
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DOI: https://doi.org/10.1007/978-1-4613-2147-7_10
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