Skip to main content

Topographic Distribution of Catecholaminergic Neurons in the Rat Medulla Oblongata Using Quantitative Three-Dimensional Reconstruction

  • Chapter
Quantitative Neuroanatomy in Transmitter Research

Part of the book series: Wenner-Gren Center International Symposium Series ((WGCISS,volume 42))

  • 46 Accesses

Abstract

In 1964 Dahlstrom and Fuxe (3), using the formaldehyde histofluorescence technique, first described a variety of monoamine containing neurons in the brain. A number of studies on the catecholamine (CA) neurons followed, (2,4–8,12–19,,24,) resulting in the demonstration of the existence of the following populations of CA neurons: adrenaline containing neurons — C cell groups (Hokfelt, Fuxe et al, 1974), noradrenaline containing neurons — A cell groups (Dahlstrom and Fuxe, 1964) and dopamine containing neurons. Historically, the question of monoaminergic neurons located in the brain stem has been addressed using fluorescence histochemistry and immunofluorescence techniques (1,2,3,18,19,30).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Armstrong, D.M., Pickel, V.M., Joh, T.H., Reis, D.J., Miller, R.J. (1981): Immunocytochemical localization of catecholamine synthesizing enzymes and neuropeptides in area postrema and medial nucleus tractus solitarius of rat brain. J. Comp. Neurol. 196, 505–517.

    Article  PubMed  CAS  Google Scholar 

  2. Blessing, W. W., Chalmers, J. P., Howe, P. R. C. (1978): Distribution of catecholamine-containing cell bodies in the rabbit central neurons system. J. Comp. Neurol. 179, 407–424.

    Article  PubMed  CAS  Google Scholar 

  3. Dahlstrom, A., Fuxe, K. (1964): Evidence for the existence of monoamine containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brainstem neurons. Acta Physiol. Scand. 62, (Suppl. 232), 1–55.

    Google Scholar 

  4. Fuxe, K. (1965). Evidence for the existence of monoamine neurons in the central nervous system. III. The monoamine nerve terminal. Z. Zellforsch., 65, 573–596.

    Article  PubMed  CAS  Google Scholar 

  5. Fuxe, K. (1965). Evidence for the existence of monoamines in the central nervous system. IV., The distribution of monoamine nerve terminals in the central nervous system. Acta physiol scand., 64, Suppl 247, 39–85.

    Google Scholar 

  6. Fuxe, K., Goldstein, M., Hokfelt, T., Joh, T. H. (1970). Immunohistochemical localization of dopamine-beta-hydroxylase in the peripheral and central nervous system. Res. Commun. chem. Path. Pharmacol., 1, 627–636.

    CAS  Google Scholar 

  7. Fuxe, K., Goldstein, M., Hokfelt, T., Joh, T. H. (1971). Cellular localization of dopamine-beta-hydroxylase and phenylethanolamine-N-methyl transferase as revealed by immunohistochemistry. In 0. Franko (ed.), Histochemistry of Nervous Transmission, Progress in Brain Research, Vol. 34, Elsevier, Amsterdam, 1971, pp. 127–138.

    Google Scholar 

  8. Fuxe, K., Hokfelt, T., Ungerstedt, U. (1970). Morphological and functional aspects of central monoamine neurons. Int. Rev. Neurobiol., 13, 93–126.

    Article  CAS  Google Scholar 

  9. Geffen, L.B. (1982). Histochemical and cytochemical localization of monoamine (arylethylamine) neurotransmitters. In: Chan-Palay, V. and Palay, S. (eds.) Cytochemical Methods in Neuroanatomy, Alan R. Liss Inc. New York, 119–127.

    Google Scholar 

  10. German, D. C., Schlusselberg, D. S., McMillen, B. A., McDermott, K, Smith, W. K., Woodward, D. J. (1982). Asymmetries in Human Brain Dopamine Receptor Binding: Relationship to 3-Dimensionnal Reconstruction of Midbrain Dopamine Neuorns. Society for Neuroscience Abstracts, 30. 3.

    Google Scholar 

  11. German, D. C., McDermott, K. L., Sanghera, MK., Schlusselberg, D.S., Smith, W. K. Woodward, D. J., Speciale S. G., Saper, C. B. (1983): Three-dimensional reconstruction of dopamine neurons in the mouse: strain differences in regional cell densities and pharmacology. Neurosci. Abstr. 9.

    Google Scholar 

  12. Goldstein, M. (1972). Enzymes involved in the catalysis of catecholamine biosynthesis. In R. N. Ubell (ed) Methods in Neuorchemistry, Vol. 1, Plenum Press, New York, 1972, pp. 317–340.

    Google Scholar 

  13. Goldstein, M., Agnoste, B., Freedman, L. S., Roffman, M. Ebstein, R. P., Park, D. H., Fuxe, K. and Hokfelt, T. (1973). Proc. I I. Catecholamine Symposium, Strasburg.

    Google Scholar 

  14. Goldstein, M., Fuxe, K., and Hokfelt, T., (1972). Characterization and tissue localization of catecholamine synthesizing enzymes. Pharmacol. Reve. 24, 293–309.

    CAS  Google Scholar 

  15. Goldstein, M., Fuxe, K., Hokfelt, T., and Joh, T. H. (1971). Immunohistochemical studies onphenylethanolamine-N-methyltransferase, dopadecarboxylase and dopamine-beta-hydroxylase. Experientia (Basel), 27, 951–952.

    Article  CAS  Google Scholar 

  16. Hartman, B. K., Zide, D., Udenfriend, S. (1972). The use of dopamine-B-hydroxylase as a marker for the noradrenergic pathways of the central nervous system in the rat. Proc nat. Acad. Sei. (Wash.) 69, 2722–2726.

    Article  CAS  Google Scholar 

  17. Hokfelt, T., Fuxe, K, Goldstein, M., Joh, T. H. (1973). Immunohistochemical studies of three catecholamine synthesizing enzymes: Aspects on methodology, Histochemie, 33, 231–254.

    PubMed  CAS  Google Scholar 

  18. Hokfelt, T., Fuxe, K., Goldstein, M., Johannsson, O. (1973). Evidence for adrenaline neurons in the rat brain. Acta physiol. scan. 89, 286–288.

    Article  CAS  Google Scholar 

  19. Hokfelt, T., Fuxe, K., Goldstein, M., Johansson, O. (1974): Immunohistochemical evidence for the esistence of adrenaline neurons in the rat brain. Brain Res 66: 235–251.

    Article  CAS  Google Scholar 

  20. Kalia, M., Sullivan, J.M. (1982): Brainstem projections of sensory and motor components of the vagus nerve in the rat. J. Comp. Neurol. 211, 248–264.

    Article  PubMed  CAS  Google Scholar 

  21. Kalia, M., Fuxe, K., Hokfelt, T., Johansson, O., Lang, R., Ganten, D., Cuello, C., Terenius, L. (1984): Distribution of neuropeptide immunoreactive nerve terminals within the subnuclei of the nucleus of the tractus solitarius of the rat. J. Comp. Neurol. 222, 409–444.

    Article  PubMed  CAS  Google Scholar 

  22. Lewis, M. H., Schlusselberg, D. S., Smith W. K., Hagler, H. K., Woodward, D. J., Buja, L. M. (1982). Three-Dimensional Cardiac Morphometry with Computer Graphics. Computers in Cardiology, Conference Proc.

    Google Scholar 

  23. Macagno, E. R., Levinthal, C., Sobel, I. (1979). Three-dimensionaal Computer Reconstruction of Neuronal Assemblies. Ann. Rev., Biophys. Bioeng 8, 323–351.

    Article  CAS  Google Scholar 

  24. Olson, L., Fuxe, K. (1972). Further mapping out of central noradrenaline neuorn systems: Projections of the “subcoeruleus” area. Brain Res., 43, 289–295.

    Article  PubMed  CAS  Google Scholar 

  25. Reis, D.J., Benno, R.H., Tucker, L.W., Joh, T.H. (1982) Quantitative immunocytochemistry of tyrosine hydroxylase in brain. In: Chan-Palay, V. and Palay, S. (eds.) Cytochemical methods in neuroanatomy Alan R. Liss Inc, New York, 205–228.

    Google Scholar 

  26. Schlusselberg, D. S., Smith, W. K., Culter, B. G., Woodward, D. J. (1982): A computer system for semi-automatic cell recognition in neuroanatomic studies. Neurosci. Abstr. 8, 644.

    Google Scholar 

  27. Schlusselberg, D. S., Smith, W. K., Lewis, M. H., Culter, B. G., Woodward, D. J. (1982): A general system for computer based acquisition, analysis and display of medical image data. Proc. ACM 18–25.

    Google Scholar 

  28. Smith, W. K., Schlusselberg, D. S., Woodward, D. J. (1981). A Computer System For Neuoranatomical Data Acquisition, Analysis, and Display. Society for Neuroscience Abstract 135. 18

    Google Scholar 

  29. Sternberger, L. A. (1979): Immunocytochemistry. New York: J. Wiley.

    Google Scholar 

  30. Swanson, L.W., Hartman, B.K. (1975) The central adrenaline system. An immunocytochemical study of the location of cell bodies and their efferent connections in the rat utilizing dopamine - beta - hydroxylase as a marker, J. Comp. Neurol. 163, 467–506.

    Article  PubMed  CAS  Google Scholar 

  31. Ungerstedt, U. (1971): Stereotaxic mapping of the monoamine pathways in the rat brain. Acta physiol. scand. 82, Suppl 367, 1–48.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1985 The Wenner-Gren Centre

About this chapter

Cite this chapter

Kalia, M., Woodward, D.J., Smith, W.K., Fuxe, K., Hökfelt, T., Goldstein, M. (1985). Topographic Distribution of Catecholaminergic Neurons in the Rat Medulla Oblongata Using Quantitative Three-Dimensional Reconstruction. In: Agnati, L.F., Fuxe, K. (eds) Quantitative Neuroanatomy in Transmitter Research. Wenner-Gren Center International Symposium Series, vol 42. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2139-2_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2139-2_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9263-0

  • Online ISBN: 978-1-4613-2139-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics