Three-Dimensional Computer Reconstructions of Catecholaminergic Neuronal Populations in Man
Catecholamine-containing neurons have been found to subserve numerous functions (see reviews by Moore and Bloom, 1978, 1979; Mason, 1981). For example, dopamine (DA) and norepinephrine (NF) containing cells in the hypothalamus regulate pituitary hormone output. The midbrain DA neurons of the substantia nigra (nucleus A9) which innervate the neostriatum, play a role in motor control and cell loss in this nucleus is pathognomonic for Parkinson’s disease. The ventral tegmental area DA neurons (nucleus A10), which innervate limbic and specific cortical regions (frontal, cingulate and entorhinal cortex) have been implicated in emotional regulation. Alteration of the receptors of these neurons is thought to be the mode of antipsychotic action for neuroleptic drugs. The locus coeruleus (LC) NF neurons, which diffusely innervate the entire cerebral cortex and spinal cord regions, have been hypothesized to play a role in arousal, attention and anxiety.
KeywordsFormalin Dopamine Tyrosine Dementia Norepinephrine
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