Abstract
A useful model system for exploring the molecular mechanisms underlying the proliferation of eucaryotic cells is the mode of action of the cellular mitogen epidermal growth factor (EGF). Epidermal growth factor is a small protein containing 53 amino acid residues (Carpenter and Cohen, 1980). It binds tightly to a specific membrane receptor. The occupation of the receptor molecule leads to activation of the pleiotropic response culminating in DNA synthesis and cell proliferation (Carpenter and Cohen, 1980; Schlessinger 1983).
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© 1985 Plenum Press, New York
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Schlessinger, J. et al. (1985). The Membrane Receptor for Epidermal Growth Factor. In: Poste, G., Crooke, S.T. (eds) Mechanisms of Receptor Regulation. New Horizons in Therapeutics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2131-6_3
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DOI: https://doi.org/10.1007/978-1-4613-2131-6_3
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