Mechanisms that Regulate Membrane Growth Factor Receptors
Cell-surface receptors for hormones and other physiologically active agents play critically important roles in signaling and coordinating a multitude of cellular functions. The molecular mechanisms whereby receptor- mediated transmembrane signaling occurs have been intensively studied during the past two decades, and significant insight has been obtained about some of these mechanisms. For example, receptors linked to the generation of cAMP are known to interact with adenylate cyclase through the action of GTP binding (coupling) proteins, which have been purified to homogeneity (Gilman, 1984). On the other hand, many other receptor systems, notably the growth factor receptors, participate in signaling mechanisms that are as yet not understood. An important future objective is the elucidation of signaling mechanisms related to this latter category of receptor systems.
KeywordsEpidermal Growth Factor Receptor Insulin Receptor Phorbol Ester Tyrosine Kinase Activity Epidermal Growth Factor Binding
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