Aneuploidy pp 117-132 | Cite as

Maternal Age, Paternal Age, and Human Chromosome Abnormality: Nature, Magnitude, Etiology, and Mechanisms of Effects

  • Ernest B. Hook
Part of the Basic Life Sciences book series (BLSC, volume 36)


An association of advanced maternal age with the trisomy 21 phenotype, Down syndrome, has been known for many years and has been found in all ethnic, racial, and socioeconomic groups investigated. (For references see Ret. 25 and 41.) More recently, an association of advanced maternal age with other chromosome abnormalities, both viable and nonviable, has been reported. Maternal-age effects and their mechanisms are discussed extensively in sections that follow.


Down Syndrome Spontaneous Abortion Extra Chromosome Chiasma Frequency Paternal Origin 
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Copyright information

© Plenum Press, New York 1985

Authors and Affiliations

  • Ernest B. Hook
    • 1
    • 2
  1. 1.Bureau of Child Health ServicesNew York State Department of HealthAlbanyUSA
  2. 2.PediatricsAlbany Medical CollegeAlbanyUSA

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