A Critique of Modeling Population Responses for Mammalian Central Neurons

  • Wayne E. Crill

Abstract

We must still be extremely cautious in accepting the conclusions reached by modeling the responses of neurons in the central mammalian nervous system. Although we know a great deal about the properties of mammalian central neurons, very little quantitative information is available. For example, although the passive membrane properties of motoneurons have been analyzed in great detail (Rall, 1977), there are now new experiments suggesting that the estimates of membrane resistivity made a decade ago (Barrett and Crill, 1974) may be too low. Experimental results from Robert Burke’s laboratory are best explained by nonuniform passive properties over the soma and dendritic tree (Fleshman et al., 1982; Rall, 1982). The point is that we do not even have reliable quantitative values for these relatively simple linear properties of central neurons.

Keywords

Tetrodotoxin 

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Wayne E. Crill
    • 1
  1. 1.Department of Physiology and BiophysicsUniversity of WashingtonSeattleUSA

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