Disorders of Glomerular Filtration

  • Roland C. Blantz
  • Juan C. Pelayo

Abstract

In the first edition of this volume, this chapter dealing with disorders of glomerular filtration described, by necessity, few specific mechanisms of altered glomerular ultrafiltration, because the stage of development of this field of investigation was in a rather early phase of data accumulation. Since that time, there has been a considerable acceleration in the rate of accumulation of knowledge in this area. Therefore, in this second edition, we will diminish our prior emphasis on methodology and discussion of the modeling predictions of the relative impacts of the four individual determinants of glomerular ultrafiltration: (1) nephron plasma flow (RPF); (2) systemic oncotic pressure (πA); (3) the glomerular capillary hydrostatic pressure gradient (ΔP); and (4) the glomerular ultrafiltration coefficient (LpA). We refer the reader to the first edition of this text for this more methodologic and theoretical discussion. We will now focus upon what is currently known regarding the specific mechanisms contributing to the regulation of glomerular ultrafiltration in a variety of physiologic and pathophysiologic conditions. Because of the increasing complexity of the regulatory processes, the descriptions of these mechanisms will be classified by physiologic conditions rather than focusing specifically on the effects of changes in the respective determinants of glomerular ultrafiltration.

Keywords

Uranium Norepinephrine Proteinuria Acetylcholine Stein 

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References

  1. 1.
    Blantz, R. C. 1978. Disorders of glomerular filtration. In: Physiology of Membrane Disorders. T. E. Andreoli, J. F. Hoffman, and D. D. Fanestil, eds. Plenum Press, New York, pp. 967–985.Google Scholar
  2. 2.
    Blantz, R. C. 1980. Segmental renal vascular resistance: Single nephron. Annu. Rev. Physiol. 42: 573–588.PubMedCrossRefGoogle Scholar
  3. 3.
    Chang, R. L. S., W. M. Deen, C. R. Robertson, and B. M. Brenner. 1975. Permselectivity of the glomerular capillary wall. III. Restricted transport of polyanions. Kidney Int. 8: 212–218.PubMedCrossRefGoogle Scholar
  4. 4.
    Brenner, B. M., J. L. Troy, and T. M. Daugharty. 1971. The dynamics of glomerular ultrafiltration in the rat. J. Clin. Invest. 50: 1776–1780.PubMedCrossRefGoogle Scholar
  5. 5.
    Blantz, R. C. 1975. The mechanism of acute renal failure after uranyl nitrate. J. Clin. Invest. 55: 621–635.PubMedCrossRefGoogle Scholar
  6. 6.
    Andreucci, V. E., J. Herrera-Acosta, F. C. Rector, Jr., and D. W. Seldin. 1971. Effective glomerular filtration pressure and single nephron filtration rate during hydropenia, elevated ureteral pressure, and acute volume expansion with isotonic saline. J. Clin. Invest. 50: 2230–2234.PubMedCrossRefGoogle Scholar
  7. 7.
    Blantz, R. C., A. H. Israelit, F. C. Rector, Jr., and D. W. Seldin. 1972. The relation of distal tubular NaCl delivery and glomerular hydrostatic pressure. Kidney Int. 2: 22–32.PubMedCrossRefGoogle Scholar
  8. 8.
    Ott, C.E.,G.R.Marchand, J. Diaz-Buxo, and F.G.Knox. 1977. The determinants of glomerular filtration in the dog. Am. J. Physiol. 231: 235–239.Google Scholar
  9. 9.
    Israelit, A. H., F. C. Rector, Jr., and D. W. Seldin. 1971. Glomerular hydrostatic pressure (PG) and effective filtration pressure (EFP) in the dog during hydropenia (H), acute volume expansion (VE), and aortic constriction (AC). Clin. Res. 19: 534A.Google Scholar
  10. 10.
    Tucker, B. J., and R. C. Blantz. 1977. An analysis of the determinants of nephron filtration rate. Am. J. Physiol. 232: F477–F483.PubMedGoogle Scholar
  11. 11.
    Brenner, B. M., J. L. Troy, T. M. Daugharty, W. M. Deen, and C. R. Robertson. 1972. Dynamics of glomerular ultrafiltration in the rat II. Plasma flow dependence of GFR. Am. J. Physiol. 223: 1184–1190.PubMedGoogle Scholar
  12. 12.
    Blantz, R. C. 1977. Dynamics of glomerular ultrafiltration in the rat. Fed. Proc. 36: 2602–2608.PubMedGoogle Scholar
  13. 13.
    Blantz, R. C., F. C. Rector, Jr., and D. W. Seldin. 1974. The effect of hyperoncotic albumin expansion upon glomerular ultra-filtration in the rat. Kidney Int. 6: 209–221.PubMedCrossRefGoogle Scholar
  14. 14.
    Baylis, G., I. Ichikawa, W. T. Willis, C. B. Wilson, and B. M. Brenner. 1977. Dynamics of glomerular ultrafiltration. IX. Effects of plasma protein concentration. Am. J. Physiol. 232: F58–F71.PubMedGoogle Scholar
  15. 15.
    Tucker, B. J., and R. C. Blantz. 1981. Effects of glomerular filtration dynamics on the glomerular permeability coefficient. Am. J. Physiol. 240: F245–F254.PubMedGoogle Scholar
  16. 16.
    Tucker, B. J., and R. C. Blantz. 1977. Factors determining superficial nephron filtration in the mature, growing rat. Am. J. Physiol. 232: F97–F104.PubMedGoogle Scholar
  17. 17.
    Myers, B. D., W. Deen, and B. M. Brenner. 1975. Effects of norepinephrine and angiotensin II on the determinants of glomerular ultrafiltration and proximal tubule fluid reabsorption in the rat. Circ. Res. 37: 101–110.PubMedGoogle Scholar
  18. 18.
    Blantz, R. C., K. S. Konnen, and B. J. Tucker. 1976. Angiotensin II effects upon the glomerular microcirculation and ultrafiltration coefficient of the rat. J. Clin. Invest. 57: 419–434.PubMedCrossRefGoogle Scholar
  19. 19.
    Baylis, C., W. M. Deen, B. D. Myers, and B. M. Brenner. 1977. Effects of some vasodilator drugs on transcapillary fluid exchange in the renal cortex. Am. J. Physiol. 230: 1148–1158.Google Scholar
  20. 20.
    Ichikawa, I., and B. M. Brenner. 1979. Mechanism of action of histamine and histamine antagonists on the glomerular microcir-culation of the rat. Circ. Res. 45: 737–745.PubMedGoogle Scholar
  21. 21.
    Blantz, R. C. 1980. The glomerulus, passive filter or regulatory organ? Klin. Wochenschr. 58: 957–964.PubMedCrossRefGoogle Scholar
  22. 22.
    Ichikawa, I., and B. M. Brenner. 1977. Evidence for glomerular actions of ADH and dibutyryl cyclic AMP in the rat. Am. J. Physiol. 233: F102–F117.PubMedGoogle Scholar
  23. 23.
    Edwards, R. M. 1983. Response of isolated renal microvessels to intraluminal pressure, norepinephrine and angiotensin II. Kidney Int. 23: 243a.CrossRefGoogle Scholar
  24. 24.
    Steiner, R. W., and R. C. Blantz. 1979. Acute reversal by saralasin of multiple intrarenal effects of angiotensin II. Am. J. Physiol. 237: F386–F391.PubMedGoogle Scholar
  25. 25.
    Baylis, C., and B. M. Brenner. 1978. Modulation by prostaglandin synthesis inhibitors of the action of exogenous angiotensin II on glomerular ultrafiltration in the rat. Circ. Res. 43: 889–898.PubMedGoogle Scholar
  26. 26.
    Ichikawa, I., J. F. Miele, and B. M. Brenner. 1979. Reversal of renal cortical actions of angiotensin II by verapamil and manganese. Kidney Int. 16: 137–147.PubMedCrossRefGoogle Scholar
  27. 27.
    Hornych, H., M. Beaufils, and G. Richet. 1972. The effect of exogenous angiotensin on superficial and deep glomeruli in the rat kidney. Kidney Int. 2: 336–343.PubMedCrossRefGoogle Scholar
  28. 28.
    Sraer, J. D., J. Sraer, R. Ardaillou, and O. Mimoune. 1974. Evidence for renal glomerular receptors for angiotensin II. Kidney Int. 6: 241–246.PubMedCrossRefGoogle Scholar
  29. 29.
    Sraer, J., L. Baud, J. P. Cosyns, P. Verroust, M. P. Nivez, and R. Ardaillou. 1977. High affinity binding of 125I-angiotensin II to rat glomerular basement membranes. J. Clin. Invest. 59: 69–81.PubMedCrossRefGoogle Scholar
  30. 30.
    Ausiello, D. A., J. I. Kreisberg, C. Roy, and M. J. Karnovsky. 1980. Contraction of cultured rat glomerular cells of apparent mesangial origin after stimulation with angiotensin II and arginine vasopressin. J. Clin. Invest. 65: 754–760.PubMedCrossRefGoogle Scholar
  31. 31.
    Beaufils, M., J. Sraer, C. Leprevx, and R. Ardaillou. 1976. Angiotensin II binding to renal glomeruli from sodium-loaded and sodium-depleted rats. Am. J. Physiol. 230: 1187–1193.PubMedGoogle Scholar
  32. 32.
    Osborne, M. J., B. Droz, P. Meyer, and F. Morel. 1975. An-giotensin II: Renal localization in glomerular mesangial cells by autoradiography. Kidney Int. 8: 245–254.PubMedCrossRefGoogle Scholar
  33. 33.
    Brown, G. P., J. G. Douglas, and J. Krontiris-Litowitz. 1980. Properties of angiotensin II receptors of isolated rat glomeruli: Factors influencing binding affinity and comparative binding of angiotensin analogs. Endocrinology 106: 1923–1929.PubMedCrossRefGoogle Scholar
  34. 34.
    Barnes, L. D., M. N. Guyman, M. D. Lifschitz, and J. I. Kreisberg. 1981. Angiotensin II receptors in mesangial cells cultured from rat renal glomeruli. Kidney Int. 19: 163a.Google Scholar
  35. 35.
    Mahieu, P. R., J. B. Foidart, C. H. Dubois, C. A. Dechenne, and J. Deheneffe. 1980. Tissue culture of normal rat glomeruli: Con-tractile activity of the cultured mesangial cells. Invest. Cell Pathol. 3: 121–128.PubMedGoogle Scholar
  36. 36.
    Blanc, E., J. Sraer, J. D. Sraer, L. Baud, and R. Ardaillou. 1978. Ca+ + and Mg+ + dependence of angiotensin II binding to isolated rat glomeruli. Biochem. Pharmacol. 27: 517–524.PubMedCrossRefGoogle Scholar
  37. 37.
    Freer, R. J. 1975. Calcium and angiotensin tachyphylaxis in rat uterine smooth muscle. Am. J. Physiol. 228: 1423–1430.PubMedGoogle Scholar
  38. 38.
    Zimmerhackl, B., N. Parekh, H. Kuecherer, and M. Steinhausen. 1982. Influence of angiotensin II on red cell velocity, red cell flux and capillary diameter of surface glomeruli of rats. Pfluegers Arch. 394(Suppl.):R25a.Google Scholar
  39. 39.
    Muller, J., and L. Barajas. 1972. Electron microscopic and histo- chemical evidence for a tubular innervation in the renal cortex of the monkey. J. Ultrastruct. Res. 41: 533–549.PubMedCrossRefGoogle Scholar
  40. 40.
    Barajas, L., and J. Muller. 1973. The innervation of the jux-taglomerular apparatus and surrounding tubules: A qualitative analysis by serial section electron microscopy. J. Ultrastruct. Res. 43: 107–132.PubMedCrossRefGoogle Scholar
  41. 41.
    Gavendo, S., S. Kapuler, I. Serban, I. Iania, E. Ben-David, and H. Eliahou. 1980. Beta-1 adrenergic receptors in kidney tubular cell membrane in the rat. Kidney Int. 17: 764–770.PubMedCrossRefGoogle Scholar
  42. 42.
    Snavely, M. D., E. Moustafa, H. J. Motulsky, L. C. Mahan, and P. A. Insel. 1982. Beta-adrenergic receptor subtypes in the rat renal cortex: Selective regulation of beta1-adrenergic receptors by pheochromocytoma. Circ. Res. 51: 504 - 513.PubMedGoogle Scholar
  43. 43.
    Snavely, M. D., and P. A. Insel. 1982. Characterization of alpha-adrenergic receptor subtypes in the rat renal cortex: Differential regulation of alpha1-and alpha2-adrenergic receptors by guanyl- nucleotides and Na+. Mol. Pharmacol. 22: 532–546.PubMedGoogle Scholar
  44. 44.
    Felder, R., J. C. Pelayo, A. Wargo, L. Schoelkopf, M. Cooke, P. Jose, and G. Eisner. 1980. Glomerular adrenergic receptors. Physiologist 23: 162a.Google Scholar
  45. 45.
    Felder, R., L. Schoelkopf, J. C. Pelayo, M. Blecher, P. Calcagno, G. Eisner, and P. Jose. 1981. Adrenergic and dopaminergic receptors in glomeruli and cortical tubules. Kidney Int. 19: 239a.Google Scholar
  46. 46.
    Andreucci, V. E., A. Dal Canton, A. Corradi, R. Stanziale, and L. Migone. 1976. Role of the efferent arteriole in glomerular hemodynamics of superficial nephrons. Kidney Int. 9: 475–480.PubMedCrossRefGoogle Scholar
  47. 47.
    Hoffman, B. B., and R. J. Lefkowitz. 1980. Radioligand binding studies of adrenergic receptors: New insights into molecular and physiological regulation. Annu. Rev. Pharmacol. Toxicol. 20: 581–608.PubMedCrossRefGoogle Scholar
  48. 48.
    Schrier, R. W. 1974. Effects of adrenergic nervous system and catecholamines on systemic and renal hemodynamics, sodium and water excretion, and renin secretion. Kidney Int. 6: 291–306.PubMedCrossRefGoogle Scholar
  49. 49.
    Pelayo, J. C., B. J. Tucker, and R. C. Blantz. 1983. Differential effects of methoxamine and isoproterenol on glomerular hemodynamics. Kidney Int. 23: 247a.Google Scholar
  50. 50.
    DiBona, G. F. 1982. The functions of the renal nerves. Rev. Physiol. Biochem. Pharmacol. 94: 76–181.Google Scholar
  51. 51.
    Keeton, T. K., and W, B. Campbell. 1980. The pharmacologic alteration of renin release. Pharmacol. Rev. 32: 81–212.PubMedGoogle Scholar
  52. 52.
    Fray, J. C. S. 1980. Stimulus-secretion coupling of renin. Circ. Res. 47: 485–493.PubMedGoogle Scholar
  53. 53.
    Hermansson, K., M. Larson, O. Kallskog, and M. Wolgast. 1981. Influence of renal nerve activity on arteriolar resistance, ultrafiltration dynamics and fluid reabsorption. Pfluegers Arch. 389: 85–90.CrossRefGoogle Scholar
  54. 54.
    Kon, V., J. L. Troy, and I. Ichikawa. 1982. Effector loci for vasomotor control by renal nerves. Clin. Res. 30: 454A.Google Scholar
  55. 55.
    Pelayo, J. C., M. G. Ziegler, and R. C. Blantz. 1984. Angiotensin II in adrenergic-induced alterations in glomerular hemodynamics. Am. J. Physiol. 247: F799–F807.PubMedGoogle Scholar
  56. 56.
    Pelayo, J. C., M. G. Ziegler, P. A. Jose, and R. C. Blantz. 1983. Renal denervation in the rat: Analysis of glomerular and proximal tubular function. Am. J. Physiol. 244: F70–F77.PubMedGoogle Scholar
  57. 57.
    Jamison, R. L. 1981. Urine concentration and dilution. The roles of antidiuretic hormone and urea. In: The Kidney, Volume 1, 2nd ed. B. M. Brenner and F. C. Rector, Jr., eds. Saunders, Philadelphia. pp. 495–550.Google Scholar
  58. 58.
    Hays, R. M., and B. D. Levine. 1981. Pathophysiology of water metabolism. In: The Kidney, Volume 1, 2nd ed. B. M. Brenner and F. C. Rector, Jr., eds. Saunders, Philadelphia, pp. 777–840.Google Scholar
  59. 59.
    Imbert, M., D. Chabardes, and F. Morel. 1974. Hormone-sensitive adenylate cyclase in isolated rabbit glomeruli. Mol. Cell. Endocrinol. 1: 295–304.CrossRefGoogle Scholar
  60. 60.
    Sraer, J., R. Ardaillou, N. Loreau, and J. D. Sraer. 1974. Evidence for parathyroid hormone sensitive adenylate cyclase in rat glomeruli. Mol. Cell. Endocrinol. 1: 285–294.CrossRefGoogle Scholar
  61. 61.
    Schlondorff, D., P. Yoo, and B. E. Alpert. 1978. Stimulation of adenylate cyclase in isolated rat glomeruli by prostaglandins. Am. J. Physiol. 235: 458–464.Google Scholar
  62. 62.
    Schor, N., I. Ichikawa, and B. M. Brenner. 1981. Mechanisms of action of various hormones and vasoactive substances on glomerular ultrafiltration in the rat. Kidney Int. 20: 442–451.PubMedCrossRefGoogle Scholar
  63. 63.
    Hassid, A., and M. J. Dunn. 1980. Microsomal prostaglandin biosynthesis of human kidney. J. Biol. Chem. 255: 2472–2475.PubMedGoogle Scholar
  64. 64.
    Stollenwerk, P. A., M. Aikawa, and M. J. Dunn. 1981. Prostaglandin and thromboxane synthesis by rat glomerular epithelial cells. Kidney Int. 20: 469–474.CrossRefGoogle Scholar
  65. 65.
    McGiff, J. C., and P. Y.-K. Wong. 1979. Compartmentalization of prostaglandins and prostacyclin within the kidney: Implications for renal function. Fed. Proc. 38: 89–93.PubMedGoogle Scholar
  66. 66.
    Dunn, M. J., and E. J. Zambraski. 1980. Renal effects of drugs that inhibit prostaglandin synthesis. Kidney Int. 18: 609–622.PubMedCrossRefGoogle Scholar
  67. 67.
    McGiff, J. C. 1981. Prostaglandins, prostacyclin, and thromboxanes. Annu. Rev. Pharmacol. Toxicol. 21: 479 - 509.PubMedCrossRefGoogle Scholar
  68. 68.
    Stokes, J. B. 1981. Integrated actions of renal medullary prostaglandins in the control of water excretion. Am. J. Physiol. 240: F471–F480.PubMedGoogle Scholar
  69. 69.
    Dunn, M. J., and L. L. Hood. 1977. Prostaglandins and the kidney. Am. J. Physiol. 233: F169–F184.Google Scholar
  70. 70.
    Terragno, N. A. 1981. Prostaglandins, antidiuretic hormone and rpnin angiotensin system. Hypertension 3(Suppl. II):II-65–II-70.Google Scholar
  71. 71.
    Baer, P. G., L. G. Navar, and A. C. Guyton. 1970. Renal auto-regulation, filtration rate and electrolyte excretion during vasodilation. Am. J. Physiol. 219: 619–625.PubMedGoogle Scholar
  72. 72.
    Johnson, H. H., J. P. Herzog, and D. P. Lavler. 1967. Effect of prostaglandin E1 on renal hemodynamics, sodium and water excretion. Am. J. Physiol. 213: 939–946.Google Scholar
  73. 73.
    Strandhoy, J. W., C. E. Ott, E. G. Schneider, L. R. Willis, N. P. Beck, B. B. Davis, and F. G. Knox. 1974. Effects of prostaglandin E1 and E2 on renal sodium reabsorption and Starling forces. Am. J. Physiol. 226: 1015–1021.PubMedGoogle Scholar
  74. 74.
    Ichikawa, I., J. M. Pfeffer, M. A. Pfeffer, T. H. Hostetter, E. Braunwald, and B. M. Brenner. 1983. Glomerular response to severe congestive heart failure in the rat. Kidney Int. 23: 245a.Google Scholar
  75. 75.
    Scharschmidt, L. A., M. J. Dunn, and A. Norris. 1983. Prostaglandins modulate angiotensin II stimulated glomerular contractility. Kidney Int. 23: 284a.Google Scholar
  76. 76.
    Ichikawa, I., H. D. Humes, T. P. Dousa, and B. M. Brenner. 1978. Influence of parathyroid hormone on glomerular ultrafiltration in the rat. Am. J. Physiol. 234: F393–F401.PubMedGoogle Scholar
  77. 77.
    Humes, H. D., I. Ichikawa, J. L. Troy, and B. M. Brenner. 1978. Evidence for a parathyroid hormone-dependent influence of calcium on the glomerular ultrafiltration coefficient. J. Clin. Invest. 61: 32–40.PubMedCrossRefGoogle Scholar
  78. 78.
    Dousa, T. P., L. D. Barnes, S. H. Ong, and A. L. Steiner. 1977. Immunohistochemical localization of 3’,5’-cyclic AMP and 3’,5’-cyclic GMP in rat renal cortex: Effect of parathyroid hormone. Proc. Natl. Acad. Sci. USA 74: 3569–3573.PubMedCrossRefGoogle Scholar
  79. 79.
    Torres, V. E., T. E. Northrup, R. M. Edwards, S. V. Shah, and T. P. Dousa. 1978. Modulation of cyclic nucleotides in isolated rat glomeruli. J. Clin. Invest. 62: 1334–1343.PubMedCrossRefGoogle Scholar
  80. 80.
    Deen, W. M., C. R. Robertson, and B. M. Brenner. 1974. Glomerular ultrafiltration. Fed. Proc. 33: 14–20.PubMedGoogle Scholar
  81. 81.
    Davis, J. O., and D. S. Howell. 1953. Comparative effect of ACTH, cortisone and DOC A on renal function, electrolyte excretion and water exchange in normal dogs. Endocrinology 52: 245–255.PubMedCrossRefGoogle Scholar
  82. 82.
    De Bermudez, L., and J. P. Hayslett. 1972. Effect of methylprednisolone on renal function and the zonal distribution of blood flow in the rat. Circ. Res. 33: 44–52.Google Scholar
  83. 83.
    Baylis, C., and B. M. Brenner. 1978. Mechanism of the glucocorticoid-induced increase in glomerular filtration rate. Am. J. Physiol. 234: F166–F170.PubMedGoogle Scholar
  84. 84.
    Campbell, W. B., R. M. Graham, and E. K. Jackson. 1979. Role of renal prostaglandins in sympathetically mediated renin release in the rat. J. Clin. Invest. 64: 448–456.PubMedCrossRefGoogle Scholar
  85. 85.
    Hofbauer, K. G., A. Konrads, K. Schwartz, and U. Werner. 1978. Role of cyclic AMP in the regulation of renin release from the isolated perfused rat kidney. Klin. Wochenschr. 56 (Suppl. l): 51–59.PubMedCrossRefGoogle Scholar
  86. 86.
    Michelakis, A. M., J. Caudle, and G. W. Liddle. 1969. In vitro stimulation of renin production by epinephrine, norepinephrine and cyclic AMP. Proc. Soc. Exp. Biol. Med. 130: 748–753.PubMedGoogle Scholar
  87. 87.
    Okahara, T., T. Abe, and K. Yamamoto. 1977. Effects of di- butyryl cyclic AMP and propranolol on renin secretion in dogs. Proc. Soc. Exp. Biol. Med. 159: 213–218.Google Scholar
  88. 88.
    Wimer, N., D. S. Chokshi, and N. G. Walkenhorst. 1971. Effects of cyclic AMP, sympathomimetic amines and adrenergic receptors antagonist on renin secretion. Circ. Res. 29: 239–248.Google Scholar
  89. 89.
    Robertson, C. R., W. M. Deen, J. L. Troy, and B. M. Brenner. 1972. Dynamics of glomerular ultrafiltration in the rat. III. Hemodynamics and autoregulation. Am. J. Physiol. 223: 1191–1200.PubMedGoogle Scholar
  90. 90.
    Deen, W. M., C. R. Robertson, and B. M. Brenner. 1973. The dynamics of glomerular filtration coefficient. J. Clin. Invest. 52: 1500–1508.PubMedCrossRefGoogle Scholar
  91. 91.
    Ichikawa, I., and B. M. Brenner. 1980. Importance of efferent arteriolar vascular tone in regulation of proximal tubule fluid reabsorption and glomerulotubular balance in the rat. J. Clin. Invest. 65: 1192–1201.PubMedCrossRefGoogle Scholar
  92. 92.
    Navar, L. G., D. W. Ploth, and P. D. Bell. 1980. Distal tubular feedback control of renal hemodynamics and autoregulation. Annu. Rev. Physiol. 42: 557–571.PubMedCrossRefGoogle Scholar
  93. 93.
    Blantz, R. C. 1974. Effect of mannitol on glomerular ultrafiltration in the hydropenic rat. J. Clin. Invest. 54: 1135–1143.PubMedCrossRefGoogle Scholar
  94. 94.
    Steiner, R. W., B. J. Tucker, and R. C. Blantz. 1979. Glomerular hemodynamics in rats with chronic sodium depletion. J. Clin. Invest. 64: 503–512.PubMedCrossRefGoogle Scholar
  95. 95.
    Tucker, B. J., and R. C. Blantz. 1983. Mechanism of altered glomerular hemodynamics during chronic sodium depletion. Am. J. Physiol. 244: F11–F18.PubMedGoogle Scholar
  96. 96.
    Schor, N., I. Ichikawa, and B. M. Brenner. 1980. Glomerular adaptations to chronic dietary salt restriction or excess. Am. J. Physiol. 238: F428–F436.PubMedGoogle Scholar
  97. 97.
    Kiil, F., and K. Aukland. 1961. Renal concentration mechanism and hemodynamics at increased ureteral pressure during osmotic and saline diuresis. Scand. J. Clin. Invest. 13: 276–287.PubMedCrossRefGoogle Scholar
  98. 98.
    Suki, W. N., A. G. Guthrie, M. Martinez-Maldonado, and G. Eknoyan. 1971. Effects of ureteral pressure elevation on renal hemodynamics and urine concentration. Am. J. Physiol. 220: 38–43.PubMedGoogle Scholar
  99. 99.
    Blantz, R. C., K. Konnen, and B. J. Tucker. 1975. Glomerular filtration response to elevated ureteral pressure in both the hydropenic and plasma expanded rat. Circ. Res. 37: 819–829.PubMedGoogle Scholar
  100. 100.
    DiBona, G. F. 1971. Effect of mannitol diuresis and ureteral occlusion on distal tubular reabsorption. Am. J. Physiol. 221: 511–514.PubMedGoogle Scholar
  101. 101.
    Steinhausen, M. 1967. Measurement of tubular urine flows and tubular reabsorption under increased ureteral pressure. Pfluegers Arch. 298: 105–130.CrossRefGoogle Scholar
  102. 102.
    Kallskog, O., and M. Wolgast. 1975. Effect of elevated interstitial pressure on the renal cortical hemodynamics. Acta Physiol. Scand. 95: 364–372.PubMedCrossRefGoogle Scholar
  103. 103.
    Dal Canton, A., R. Stanziale, A. Corradi, V. E. Andreucci, and L. Migone. 1977. Effects of acute ureteral obstruction on glomerular hemodynamics in the rat kidney. Kidney Int. 12: 403–411.CrossRefGoogle Scholar
  104. 104.
    Dal Canton, A., A. Corradi, R. Stanziale, G. Maruccio, and L. Migone. 1979. Effects of 24 hours unilateral ureteral obstruction on glomerular hemodynamics in rat kidney. Kidney Int. 15: 457–462.CrossRefGoogle Scholar
  105. 105.
    Arendshorst, W. J., W. F. Finn, and C. W. Gottschalk. 1974. Nephron stop-flow pressure response to obstruction for 24 hours in the rat kidney. J. Clin. Invest. 53: 1497–1500.PubMedCrossRefGoogle Scholar
  106. 106.
    Dal Canton, A., A. Corradi, R. Stanziale, G. Maruccio, and L. Migone. 1980. Glomerular hemodynamics before and after release of 24-hour bilateral ureteral obstruction. Kidney Int. 17: 491–496.CrossRefGoogle Scholar
  107. 107.
    Humes, H. D., R. A. Dieppa, and B. M. Brenner. 1980. Glomerular hemodynamics in rats with hereditary hydronephrosis. Invest. Urol. 18: 46–51.PubMedGoogle Scholar
  108. 108.
    Ichikawa, I., and B. M. Brenner. 1979. Local intrarenal vasoconstrictor-vasodilator interactions in mild partial ureteral obstruction. Am. J. Physiol. 236: F131–F140.PubMedGoogle Scholar
  109. 109.
    Kishimoto, T., M. Maekawa, Y. Abe, and K. Yamamoto. 1973. Intrarenal distribution of blood flow and renin release during renal venous pressure elevation. Kidney Int. 4: 259–266.PubMedCrossRefGoogle Scholar
  110. 110.
    Miyazake, M., and J. McNay. 1971. Redistribution of renal cortical blood flow during ureteral occlusion and renal venous constriction. Proc. Soc. Exp. Biol. Med. 138: 454–461.Google Scholar
  111. 111.
    Lewy, J. E., and E. E. Windhager. 1968. Peritubular control of proximal tubular fluid reabsorption in the rat kidney. Am. J. Physiol. 214: 943–954.PubMedGoogle Scholar
  112. 112.
    Rodicio, J., J. Herrera-Acosta, J. C. Sellman, F. C. Rector, Jr., and D. W. Seldin. 1969. Studies on glomerulo-tubular balance during aortic constriction, ureteral obstruction and venous occlusion in hydropenic and saline-expanded rats. Nephron 6: 437–456.PubMedCrossRefGoogle Scholar
  113. 113.
    Tucker, B. J., and R. C. Blantz. 1978. Determinants of proximal tubular reabsorption as mechanisms of glomerulotubular balance. Am. J. Physiol. 235: F142–F150.PubMedGoogle Scholar
  114. 114.
    Dilley, J. R., A. Corradi, and W. J. Arendshorst. 1983. Glomerular ultrafiltration dynamics during increased renal venous pressure. Am. J. Physiol. 244: F650–F658.PubMedGoogle Scholar
  115. 115.
    Corradi, A., and W. J. Arendshorst. 1982. Effect of increased renal venous pressure on renal hemodynamics in the rat. Kidney Int. 21: 241a.Google Scholar
  116. 116.
    Corradi, A., and W. J. Arendshorst. 1982. Influence of renal nerves and prostaglandins in renal hemodynamic responses to elevated renal venous pressure in the rat. Fed. Proc. 41: 1256a.Google Scholar
  117. 117.
    Davison, J. M., and W. Dunlop. 1980. Renal hemodynamics and tubular function in normal human pregnancy. Kidney Int. 18: 152–161.PubMedCrossRefGoogle Scholar
  118. 118.
    Alexander, E. A., S. Churchill, and H. H. Bengele. 1980. Renal hemodynamics and volume homeostasis during pregnancy in the rat. Kidney Int. 18: 173–178.PubMedCrossRefGoogle Scholar
  119. 119.
    Baylis, C. 1980. The mechanism of the increase in glomerular filtration rate in the 12-day pregnant rat. J. Physiol. (London) 305: 405–414.Google Scholar
  120. 120.
    Dal Canton, A., G. Conte, C. Sposito, G. Fuiano, R. Guasco, D. Russo, M. Sabbatini, F. Uccello, and V. E. Andreucci. 1982. Effects of pregnancy on glomerular hemodynamics: Micropuncture study in the rat. Kidney Int. 22: 608–612.CrossRefGoogle Scholar
  121. 121.
    Baylis, C. 1982. Glomerular ultrafiltration in the pseudopregnant rat. Am. J. Physiol. 234: F300–F305.Google Scholar
  122. 122.
    Baylis, C. 1979/80. The effect of early pregnancy on glomerular filtration rate and plasma volume in the rat. Renal Physiol. 2: 333–339.Google Scholar
  123. 123.
    Matthews, B. M., and D. W. Taylor. 1960. Effects of pregnancy on inulin and para-amino hippurate clearances in the anesthetized rat. J. Physiol. (London) 151: 385–389.Google Scholar
  124. 124.
    Blantz, R. C., and J. C. Pelayo. 1984. A functional role for the tubuloglomerular feedback mechanism. Kidney Int. 25: 739–746.PubMedCrossRefGoogle Scholar
  125. 125.
    Thurau, K. 1964. Renal hemodynamics. Am. J. Med. 36:698–719.PubMedCrossRefGoogle Scholar
  126. 126.
    Schnermann, J., F. S. Wright, J. M. Davis, W. V. Stackelberg, and G. Grill. 1970. Regulation of superficial nephron filtration rate by tubuloglomerular feedback. Pfluegers Arch. 318:147–175.CrossRefGoogle Scholar
  127. 127.
    Blantz, R. C., and K. S. Konnen. 1977. Relation of distal tubule delivery rate and reabsorptive rate to nephron filtration. Am. J. Physiol. 233: F315–F324.PubMedGoogle Scholar
  128. 128.
    Hierholzer, K., R. Muller-Suur, H.-U. Gutsche, M. Butz, and I. Lichtenstein. 1974. Filtration in surface glomeruli as regulated by flow rate through the loop of Henle. Pfluegers Arch. 352: 315–337.CrossRefGoogle Scholar
  129. 129.
    Tucker, B. J., R. W. Steiner, L. C. Gushwa, and R. C. Blantz. 1978. Studies on the tubuloglomerular feedback system in the rat: The mechanism of reduction in filtration rate with benzolamide. J. Clin. Invest. 62: 993–1004.PubMedCrossRefGoogle Scholar
  130. 130.
    Tucker, B. J., and R. C. Blantz. 1980. Studies on the mechanism of reduction in glomerular filtration rate after benzolamide. Pfluegers Arch. 388: 211–216.CrossRefGoogle Scholar
  131. 131.
    Schnermann, J., J. Briggs, and F. S. Wright. 1981. Feedback mediated reduction of glomerular filtration rate during infusion of hypertonic saline. Kidney Int. 20: 462–468.PubMedCrossRefGoogle Scholar
  132. 132.
    Pelayo, J. C. and R. C. Blantz. 1984. Analysis of renal denervation in the hydropenic rat: Interactions with angiotensin II. Am. J. Physiol. 246: F87–F95.PubMedGoogle Scholar
  133. 133.
    Blantz, R. C., B. J. Tucker, L. Gushwa, and O. W. Peterson. 1983. Mechanism of diuresis following acute modest hyperglycemia in the rat. Am. J. Physiol. 244: F185–F194.PubMedGoogle Scholar
  134. 134.
    Blantz, R. C., O. W. Peterson, L. C. Gushwa, and B. J. Tucker. 1982. Effect of modest hyperglycemia on tubuloglomerular feedback activity. Kidney Int. 22: S206–S212.Google Scholar
  135. 135.
    Persson, A. E. G., R. Muller-Suur, and G. Selen. 1976. Peritubular capillary oncotic pressure as a modifier of tubuloglomerular feedback. Kidney Int. 19: 595–603.Google Scholar
  136. 136.
    Persson, A. E. G., R. Muller-Suur, and G. Selen. 1979. Capillary oncotic pressure as a modifier for tubuloglomerular feedback. Am. J. Physiol. 236: F97–F102.PubMedGoogle Scholar
  137. 137.
    Wright, F. S., and J. Schnermann. 1974. Interference with feedback control of glomerular filtration rate by furosemide, triflocin and cyanide. J. Clin. Invest. 53: 1695–1708.PubMedCrossRefGoogle Scholar
  138. 138.
    Tucker, B. J., and R. C. Blantz. 1984. Effect of furosemide administration on glomerular and tubular dynamics in the rat. Kidney Int. 26: 112–121.PubMedCrossRefGoogle Scholar
  139. 139.
    Moore, L. C., S. Yarimazu, G. Schubert, P. C. Weber, and J. Schnermann. 1980. Dynamics of tubuloglomerular feedback adaptation to acute and chronic changes in body fluid volume. Pfluegers Arch. 387: 39–45.CrossRefGoogle Scholar
  140. 140.
    Briggs, J. P., and F. S. Wright. 1979. Feedback control of glomerular filtration rate: Site of the effector mechanism. Am. J. Physiol. 236: F40–F47.PubMedGoogle Scholar
  141. 141.
    Ichikawa, 1. 1982. Direct analysis of the effector mechanism of the tubuloglomerular feedback system. Am. J. Physiol. 243: F447–F455.Google Scholar
  142. 142.
    Blantz, R. C. 1985. Intrinsic renal failure: Acute, In: The Kidney: Normal and Abnormal Function. D. Seldin and G. Giebisch, eds. Raven Press, New York, in press.Google Scholar
  143. 143.
    Tanner, G. A., K. L. Sloan, and S. Sophason. 1973. Effects of renal artery occlusion on kidney function in the rat. Kidney Int. 4: 377–389.PubMedCrossRefGoogle Scholar
  144. 144.
    Williams, R. H., C. E. Thomas, L. G. Navar, and A. P. Evan. 1981. Hemodynamic and single nephron function during the maintenance phase of ischemic acute renal failure in the dog. Kidney Int. 19: 503–515.PubMedCrossRefGoogle Scholar
  145. 145.
    Cox, J. W., R. W. Baehler, H. Sharma, T. O’Dorisio, R. W. Osgood, J. H. Stein, and T. F. Ferris. 1974. Studies on the mechanism of oliguria in a model of acute renal failure. J. Clin. Invest. 53: 1546–1558.PubMedCrossRefGoogle Scholar
  146. 146.
    Conger, J. D., J. B. Robinette, and S. J. Guggenheim. 1981. Effect of acetylcholine on the early phase of reversible norepinephrine-induced acute renal failure. Kidney Int. 19: 399–409.PubMedCrossRefGoogle Scholar
  147. 147.
    Myers, B., F. Chui, M. Hilberman, and A. Michaels. 1979. Transtubular leakage of glomerular filtrate in human acute renal failure. Am. J. Physiol. 237: F319–F325.PubMedGoogle Scholar
  148. 148.
    Bank, N., B. F. Mutz, and H. Aynedian. 1967. The role of “leakage” of tubular fluid in anuria due to mercury poisoning. J. Clin. Invest. 46: 695–704.PubMedCrossRefGoogle Scholar
  149. 149.
    Stein, J. H., J. Gottschall, R. W. Osgood, and T. F. Ferris. 1975. Pathophysiology of nephrotoxic model of acute renal failure. Kidney Int. 8: 27–41.PubMedCrossRefGoogle Scholar
  150. 150.
    Avasthi, P. S., A. P. Evan, and D. Hay. 1980. Glomerular endothelial cells in uranyl nitrate-induced acute renal failure in rats. J. Clin. Invest. 65: 121–127.PubMedCrossRefGoogle Scholar
  151. 151.
    Baylis, C., H. G. Rennke, and B. M. Brenner. 1977. Mechanisms of the defects in glomerular ultrafiltration associated with gentamicin administration. Kidney Int. 12: 344–352.PubMedCrossRefGoogle Scholar
  152. 152.
    Avasthi, P. S., A. P. Evan, J. W. Huser, and F. C. Luft. 1981. Effect of gentamicin on glomerular ultrastructure. J. Lab. Clin. Med. 98: 444–454.PubMedGoogle Scholar
  153. 152.
    Avasthi, P. S., A. P. Evan, J. W. Huser, and F. C. Luft. 1981. Effect of gentamicin on glomerular ultrastructure. J. Lab. Clin. Med. 98: 444–454.PubMedGoogle Scholar
  154. 154.
    Schor, N., I. Ichikawa, H. G. Rennke, J. L. Troy, and B. M, Brenner. 1981. Pathophysiology of altered glomerular function in aminoglycoside treated rats. Kidney Int. 19: 288–296.PubMedCrossRefGoogle Scholar
  155. 155.
    Conger, J., and S. Falk. 1977. Intrarenal dynamics in the pathogenesis and prevention of acute urate nephropathy. J. Clin. Invest. 59: 786–793.PubMedCrossRefGoogle Scholar
  156. 156.
    Allison, M. E. M., C. B. Wilson, and C. W. Gottschalk. 1974. Pathophysiology of experimental glomerulonephritis in rats. J. Clin. Invest. 53: 1402–1423.PubMedCrossRefGoogle Scholar
  157. 157.
    Maddox, D. A., C. M. Bennett, W. M. Deen, R. J. Glassock, D. Knutson, T. M. Daugharty, and B. M. Brenner. 1975. Determinants of glomerular filtration in experimental glomerulonephritis in the rat. J. Clin. Invest. 55: 305–318.PubMedCrossRefGoogle Scholar
  158. 158.
    Bennett, C. M., R. J. Glassock, R. L. S. Chang, W. M. Deen, C. R. Robertson, and B. M. Brenner. 1976. Permselectivity of the glomerular capillary wall: Studies of experimental glomerulonephritis in the rat using dextran sulfate. J. Clin. Invest. 57: 1287–1299.PubMedCrossRefGoogle Scholar
  159. 159.
    Blantz, R. C., and C. B. Wilson. 1976. Acute effects of anti-glomerular basement membrane antibody on the process of glomerular filtration in the rat. J. Clin. Invest. 58: 899–911.PubMedCrossRefGoogle Scholar
  160. 160.
    Blantz, R. C., B. J. Tucker, and C. B. Wilson. 1978. The acute effects of anti-glomerular basement membrane antibody on the process of glomerular filtration in the rat. II. Influence of dose and complement depletion. J. Clin. Invest. 61: 910–921.PubMedCrossRefGoogle Scholar
  161. 160.
    Blantz, R. C., B. J. Tucker, and C. B. Wilson. 1978. The acute effects of anti-glomerular basement membrane antibody on the process of glomerular filtration in the rat. II. Influence of dose and complement depletion. J. Clin. Invest. 61: 910–921.PubMedCrossRefGoogle Scholar
  162. 162.
    Blantz, R. C., B. J. Tucker, L. Gushwa, O. Peterson, and C. B. Wilson. 1981. Glomerular immune injury in the rat: The influence of All and a-adrenergic inhibitors. Kidney Int. 20: 452–461.PubMedCrossRefGoogle Scholar
  163. 163.
    Wilson, C. B., L. C. Gushwa, O. W. Peterson, B. J. Tucker, and R. C. Blantz. 1981. Glomerular immune injury in the rat: The effect of antagonists of histamine activity. Kidney Int. 20:628– 635.PubMedCrossRefGoogle Scholar
  164. 164.
    Ichikawa, I., J. R. Hoyer, M. W. Seiler, and B. M. Brenner. 1982. Mechanisms of tubuloglomerular balance in the setting of heterogeneous glomerular injury. J. Clin. Invest. 69: 185–198.PubMedCrossRefGoogle Scholar
  165. 165.
    Blantz, R. C., T. M. Hostetter, and B. M. Brenner. 1979. Functional adaptations of the kidney to immunological injury. In: Immunologic Mechanisms of Renal Disease. C. Wilson, B. Brenner, and J. Stein, eds. Churchill-Livingstone, Edinburgh, pp. 122–143.Google Scholar
  166. 166.
    Bohrer, M. D., C. Baylis, C. R. Robertson, and B. M. Brenner. 1977. Mechanism of the puromycin-induced defects in the transglomerular passage of water and macromolecules. J. Clin. Invest. 60: 152–161.PubMedCrossRefGoogle Scholar
  167. 167.
    Ichikawa, I., H. G. Rennke, J. R. Hoyer, K. F. Badr, N. Schor, J. L. Troy, C. P. Lechene, and B. M. Brenner. 1983. Role for intrarenal mechanisms in the impaired salt excretion of experimental nephrotic syndrome. J. Clin. Invest. 71: 91–103.PubMedCrossRefGoogle Scholar
  168. 168.
    Schweitzer, G., and K. H. Gertz. 1979. Changes of hemodynamics and glomerular ultrafiltration in renal hypertension of rats. Kidney Int. 15: 134–143.CrossRefGoogle Scholar
  169. 169.
    Steiner, R. W., B. J. Tucker, L. C. Gushwa, J. Gifford, C. B. Wilson, and R. C. Blantz. 1982. Glomerular hemodynamics in a moderate form of Goldblatt hypertension in the rat. Hypertension 4: 51–57.PubMedGoogle Scholar
  170. 170.
    Azar, S., M. A. Johnson, B. Hertel, and L. Tobian. 1977. Single nephron pressures, flows and resistances in hypertensive kidneys with nephrosclerosis. Kidney Int. 11: 28–36.CrossRefGoogle Scholar
  171. 171.
    Savin, V. J., and D. Terreros. 1982. A study of filtration in single isolated mammalian glomeruli. Kidney Int. 20: 188–197.CrossRefGoogle Scholar
  172. 172.
    Cachia, R., V. J. Savin, R. V. Patak, and S. M. Ridge. 1981. Effect of mercury chloride and uranyl nitrate on ultrafiltration coefficient in isolated glomeruli. Kidney Int. 19: 245a.Google Scholar
  173. 173.
    Ridge, S. M., R. V. Patak, and V. J. Savin. 1981. Effect of salt depletion and hemorrhage on ultrafiltration coefficient in isolated glomeruli. Kidney Int. 19: 254a.Google Scholar
  174. 174.
    Osgood, R. W., M. Hanley, H. J. Reineck, C. B. Wilson, M. Venkatachalam, and J. H. Stein. 1981. Isolated perfusion of isolated dog glomeruli. Kidney Int. 19: 251a.Google Scholar
  175. 175.
    Osgood, R. W., H. J. Reineck, and J. H. Stein. 1982. Methodologic considerations in the study of glomerular ultrafiltration. Am. J. Physiol. 242: F1–F7.PubMedGoogle Scholar
  176. 176.
    Bricker, N. S., and L. G. Fine. 1981. The renal response to progressive nephron loss. In: The Kidney, Volume 1, 2nd ed. B. M. Brenner and F. C. Rector, Jr., eds. Saunders, Philadelphia, pp. 1056–1096.Google Scholar
  177. 177.
    Hayslett, J. P. 1979. Functional adaptation to reduction in renal mass. Physiol. Rev. 59: 137–164.PubMedGoogle Scholar
  178. 178.
    Hostetter, T. H., and B. M. Brenner. 1981. Glomerular adaptations to renal injury. In: Contemporary Issues in Nephrology, Volume 7. B. M. Brenner and J. H. Stein, eds. Churchill-Livingstone, Edinburgh, pp. 1–27.Google Scholar
  179. 179.
    Deen, W. M., D. A. Maddox, C. R. Robertson, and B. M. Brenner. 1974. Dynamics of glomerular ultrafiltration in the rat. VII. Response to reduced renal mass. Am. J. Physiol. 227: 556–562.PubMedGoogle Scholar
  180. 180.
    Hostetter, T. H., J. L. Olson, H. G. Rennke, M. A. Venkatachalam, and B. M. Brenner. 1981. Hyperfiltration in remnant nephrons: A potentially adverse response to renal ablation. Am. J. Physiol. 241: F85–F93.PubMedGoogle Scholar
  181. 181.
    Dworkin, L. D., T. H. Hostetter, H. G. Rennke, and B. M. Brenner. 1982. Evidence for a hemodynamic basis for glomerular injury in hypertension. Kidney Int. 21: 229a.Google Scholar
  182. 182.
    Brenner, B. M., T. W. Meyer, and T. H. Hostetter. 1982. Dietary protein intake and the progressive nature of kidney disease: The role of hemodynamically mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease. N. Engl. J. Med. 307: 632–659.CrossRefGoogle Scholar
  183. 183.
    Farr, L. E., and J. E. Smadel. 1939. The effect of dietary protein on the course of nephrotoxic nephritis in rats. J. Exp. Med. 70: 615–627.PubMedCrossRefGoogle Scholar
  184. 184.
    Neugarten, J., H. Feiner, R. G. Schacht, and D. S. Baldwin. 1982. Ameliorative effect of dietary protein restriction on the course of nephrotoxic serum nephritis. Clin. Res. 30: 541A.Google Scholar
  185. 185.
    Friend, P. S., G. Fernandes, R. A. Good, A. F. Michael, and E. J. Yunis. 1978. Dietary restrictions early and late: Effects on the nephropathy of the NZB x NZW mouse. Lab. Invest. 38: 629–632.PubMedGoogle Scholar
  186. 186.
    Ichikawa, I., M. L. Purkerson, S. Klahr, J. L. Troy, M. Martinez- Maldonado, and B. M. Brenner. 1980. Mechanism of reduced glomerular filtration rate in chronic malnutrition. J. Clin. Invest. 65: 982–988.PubMedCrossRefGoogle Scholar
  187. 187.
    Karlinsky, M. L., L. Haut, B. Buddington, N. A. Schrier, and A. C. Alfrey. 1980. Preservation of renal function in experimental glomerulonephritis. Kidney Int. 17: 293–302.PubMedCrossRefGoogle Scholar
  188. 188.
    Tomford, C. R., M. L. Karlinsky, B. Buddington, and A. C. Alfrey. 1981. Effect of thyroparathyroidectomy and parathyroidectomy on renal function and the nephrotic syndrome in rat nephrotoxic serum nephritis. J. Clin. Invest. 68: 655–664.PubMedCrossRefGoogle Scholar
  189. 189.
    Tomford, C. R., B. Buddington, and A. C. Alfrey. 1982. Thy-roidectomy prevents chronic renal insufficiency in nephrotoxic serum nephritis in rats. Kidney Int. 21: 231a.Google Scholar

Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • Roland C. Blantz
    • 1
  • Juan C. Pelayo
    • 2
  1. 1.Department of MedicineUniversity of California, San Diego, School of MedicineLa JollaUSA
  2. 2.Veterans Administration Medical CenterSan DiegoUSA

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