Abstract
Enzootic outbreak of lymphoma has occured at the Sukhumi monkey colony beginning from 1967 to nowadays. This enzootic has resulted in over 280 fatal cases among baboons. Lymphoma-associated B-lymphotropic herpesvirus (HVP) antigenically related but not identical to the Epstein-Barr virus (EBV) and sharing with EBV upto 40% DNA homology, as well as T-lymphotropic C-type retrovirus H(S)TLV-I have been isolated from lymphomatous animals. The above viruses are released into the environment and spread horizontally. The majority of the disease cases among baboons represented different morphological variants of non-Hodgkin’s B- and T-cell lymphomas. No correlation between immunological type of lymphoma and the level of antibodies to HVP and H(S)TLV-I has been found. The majority of monkeys showed an increase of antibody titers to both viruses in prelymphoma period. Integrated H(S)TLV-I-like provirus was determined in baboon lymphoma DNA. HVP-specific DNA was found in tumour and some normal tissues of monkeys from the high-risk lymphoma stock.
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Lapin, B. (1988). Baboon Lymphoma Viruses. In: Darai, G. (eds) Virus Diseases in Laboratory and Captive Animals. Developments in Veterinary Virology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2091-3_7
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DOI: https://doi.org/10.1007/978-1-4613-2091-3_7
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