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Use of Hemapheresis-Derived Hemopoietic Stem Cells for Transplantation in Malignant Lymphohemopoietic Disorders

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White cells and platelets in blood transfusion

Part of the book series: Developments in Hematology and Immunology ((DIHI,volume 19))

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Abstract

The usual source of hemopoietic stem cells for transplantation is the bone marrow. However, evidence in rodents, canines and non-human primates indicates that stem cells with marrow repopulating ability also circulate in the peripheral blood [1–4]. To use the circulating blood as the primary source of stem cells to repopulate an aplastic bone marrow is a concept which reflects the physicological pattern in which fetal hemopoiesis develops. The fetal bone marrow becomes a site of hemopoiesis after pluripotent hemopoietic stem cells immigrate into its stromal matrix via the circulating blood. Thus transfusing blood-derived stem cells in adults may be considered to repeat the prenatal seeding of hemopoiesis into the bone marrow [5,6].

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Authors
  1. M. Körbling
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  2. W. Hunstein
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  3. H. Martin
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  4. R. Haas
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  5. P. Reichardt
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Editor information

Editors and Affiliations

  1. Red Cross Blood Bank Groningen-Drenthe, The Netherlands

    Cees Th. Smit Sibinga MD, PhD  & Prakash C. Das MD, PhD, FRCPath  & 

  2. Central Laboratory of the Netherlands Red Cross, Amsterdam, The Netherlands

    C. Paul Engelfriet MD, PhD (Chairman) (Chairman)

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© 1987 Martinus Nijhoff Publishing, Boston

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Körbling, M., Hunstein, W., Martin, H., Haas, R., Reichardt, P. (1987). Use of Hemapheresis-Derived Hemopoietic Stem Cells for Transplantation in Malignant Lymphohemopoietic Disorders. In: Sibinga, C.T.S., Das, P.C., Engelfriet, C.P. (eds) White cells and platelets in blood transfusion. Developments in Hematology and Immunology, vol 19. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2089-0_20

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  • DOI: https://doi.org/10.1007/978-1-4613-2089-0_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9238-8

  • Online ISBN: 978-1-4613-2089-0

  • eBook Packages: Springer Book Archive

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