Abstract
Leukocytes present in blood components are associated with some more or less important transfusion complications: The production of alloantibodies directed against HLA and/or leukocyte specific antigens can be the cause of febrile non-hemolytic transfusion reactions (FNHTR) and of refractoriness to platelet transfusion; immunocompetent leukocytes transfused to severely immunodeficient patients may react against the tissues of the recipient and may develop graft-versus-host disease (GvHD). Finally, substantial clinical evidence exists for the transmission of cytomegalovirus by leukocytes.
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© 1987 Martinus Nijhoff Publishing, Boston
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de Wolf, J.T.M. (1987). Clinical Use of Leukocyte Poor Red Cell Concentrates. In: Sibinga, C.T.S., Das, P.C., Engelfriet, C.P. (eds) White cells and platelets in blood transfusion. Developments in Hematology and Immunology, vol 19. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2089-0_11
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DOI: https://doi.org/10.1007/978-1-4613-2089-0_11
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