Clinical Aspects of Diabetes Type I and Type II

  • H. Bar-On
Part of the Developments in Medical Virology book series (DIMV, volume 2)


Diabetes mellitus is a syndrome of various genetic and environmental etiologies. The hyperglycemia and its associated metabolic, functional and pathological sequelae apparently have different mechanisms, depending on the several entities encountered. Two major clinical presentations of diabetes are reviewed in this chapter and their genetic and pathogenetic characteristics are described. Patients with diabetes will eventually develop micro- and macro-vascular complications, making their lives increasingly uncomfortable and distressing. A short report on these grave afflictions, their pathogenesis and course of disease has been given. The relationship between diabetic control and complications is also discussed. Although a lot of progress in understanding diabetes and its therapy has been made in the last six decades, a great deal is still left for future clinical and basic research to accomplish.


Beta Cell Carpal Tunnel Syndrome Metabolic Derangement Insulin Gene NIDDM Patient 
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  1. 1.
    Johnston, D.G. and Alberti, K.G.M.M. (Eds.) New aspects of diabetes. In: Clinics in Endocrinology and Metabolism, Vol. 11, No. 2, W.B. Saunders Co. Ltd., London, Philadelphia, Toronto, 1982.Google Scholar
  2. 2.
    Camerini-Davalos, R.A., Velasco, C., Glasser, M. and Bloodworth, J.M.B. Drug-induced reversal of early diabetic microangiopathy. N. Engl. J. Med. 309:1551–1556, 1983PubMedCrossRefGoogle Scholar
  3. 3.
    Siperstein, M.D., Unger, R.H. and Madison, L.L. Studies of muscle capillary basement membrane in normal subjects, diabetic, and prediabetic patients. J. Clin. Invest. 47:1973–1999, 1968.PubMedCrossRefGoogle Scholar
  4. 4.
    Platz, P., Jakobsen, B., Morling, N., Ryder, LP., Svejgaard, A. et al., HLA-D and -DR antigens in genetic analysis of insulin-dependent diabetes mellitus. Diabetologia 21:108–115, 1981.PubMedCrossRefGoogle Scholar
  5. 5.
    Bell, G.I., Horita, S. and Karam, J.H. A polymorphic locus near the human insulin gene is asociated with insulin-dependent diabetes mellitus. Diabetes 33:176–183, 1984.PubMedCrossRefGoogle Scholar
  6. 6.
    Gepts, W. Pathologic anotomy of the pancreas in juvenile diabetes mellitus. Diabetes 14:619–633, 1965.PubMedGoogle Scholar
  7. 7.
    Lernmark, A. Molecular biology of type I (insulin dependent) diabetes mellitus. Diabetoiogia 28:195–203, 1985.Google Scholar
  8. 8.
    Eisenbarth, GS. Type I diabetes mellitus. A chronic auto-immune disease. N. Engl. J. Med. 314:1360–1368, 1986.PubMedCrossRefGoogle Scholar
  9. 9.
    Abu-Bakare, A., Taylor, R., Gill, G.V. and Alberti, K.G.M.M. Tropical and malnutrition-related diabetes: A real syndrome. Lancet 1:1135–1138, 1986.PubMedCrossRefGoogle Scholar
  10. 10.
    Stiller, C.R., Dupre, J., Gent, M., Jenner, M.R. and Keown, P.A. Effects of cyclosporin immunosuppression in IDDM of recent onset. Science 223:1363–1367, 1984.CrossRefGoogle Scholar
  11. 11.
    Sussman, K. (ed.) Diabetes dialogue: The spectrum of defects in non insulin-dependent diabetes mellitus. (Proceedings of a symposium). Am. J. Med. 79 (2B): 1–44, 1985.CrossRefGoogle Scholar
  12. 12.
    Olefsky, J.M. Introduction: pathogenesis of insulin resistance and hyperglycemia in NIDDM. Am. J. Med. 79 (3B): 1–7, 1985.CrossRefGoogle Scholar
  13. 13.
    Kahn, C.R. Insulin resistance, insulin insensitivity, and insulin unresponsiveness. A necessary distinction. Metabolism 27 (suppl. 2):1893–1902. 1978.PubMedCrossRefGoogle Scholar
  14. 14.
    Ziv, E., Adler, J.H., Lior, O. and Bar-On, H. Insulin uptake by the liver of sand rat. (Abstract). Diabetes 35:158A, 1986.Google Scholar
  15. 15.
    Salzman, R., Manson, J., Griffing, G.T., Kimmerle, R., Ruderman, N., McCall, A., Stoltz, E., Mullin, C., Small, D., Armstrong, J., and Melby, J.C. Intranasal aerolized insulin. N. Engl. J. Med. 312:1078–1084, 1985.PubMedCrossRefGoogle Scholar
  16. 16.
    Raz, I., Kidron, M., Bar-On, H. and Ziv, E. Rectal administration of insulin. Israel J. Med. Sci. 20:173–175, 1984.PubMedGoogle Scholar
  17. 17.
    Ruderman, N.B. and Haudenschild. Diabetes as an atherogenic factor. Progr. Cardiovasc. Dis. 26:373–412, 1984.CrossRefGoogle Scholar
  18. 18.
    Raskin, P. and Rosenstock, J. Blood glucose control and diabetic complications. Ann. Int. Med. 105:254–263, 1986.PubMedGoogle Scholar

Additional Bibliography

  1. 1.
    Brownlee, M. (ed.) Handbook of Diabetes Mellitus (in 5 volumes). John Wiley and Sons, New York, 1981.Google Scholar
  2. 2.
    Keen, H. and Jarret, J. (eds.) Complications of Diabetes (2nd edition). Edward Arnold, London, 1982.Google Scholar
  3. 3.
    Ellenberg, M. and Rifkin, H. (eds.) Diabetes Mellitus, Theory and Practice (3rd ed). Medical Examination Publishing Co. New Hyde Park, NY, 1983.Google Scholar
  4. 4.
    Alberti, K.G.M.M. and Krall, L.P. (eds.) The Diabetes Annual/1. Elsevier Science Publishers, New York, 1985.Google Scholar
  5. 5.
    Olefsky, J.M. and Sherwin, R.S. (eds.) Diabetes Mellitus: Management and Complications. Vol. 1 of Contemporary Issues in Endocrinology and Metabolism, Churchill Livingstone Inc., New York, 1985.Google Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • H. Bar-On
    • 1
  1. 1.Diabetes UnitHadassah Medical CenterJerusalemIsrael

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