Cerebral Hyperperfusion During Cardiopulmonary Bypass: The Influence of PaCO2

  • John M. Murkin


During cardiac surgery, many institutions routinely cool patients to a core temperature between 25° to 30°C. Systemic hypothermia augments topical cooling and cardioplegia by further delaying myocardial rewarming, thus increasing the tolerance of the heart to cross-clamp induced ischemia. Acid-base and ventilatory management during hypothermic cardiopulmonary bypass (CPB) are controversial [1,2] as are many other facets of CPB including the use of pulsatile or nonpulsatile perfusion, membrane versus bubble oxygenators, selection of appropriate pump flow, and even the determination of adequate perfusion pressure during CPB. Recent studies have begun to address some of these issues, yet the results obtained appear contradictory.


Cerebral Blood Flow Mean Arterial Pressure Cardiopulmonary Bypass Cerebral Perfusion Pressure Regional Cerebral Blood Flow 
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© Martinus Nijhoff Publishing, Boston 1988

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  • John M. Murkin

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