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The lymphoid system and immunologic defense of the digestive tract

  • Jacques Pappo
  • Robert L. Owen
Chapter
Part of the Electron Microscopy in Biology and Medicine book series (EMBM, volume 4)

Abstract

Lymphocytes and macrophages are distributed in the intestinal tract as isolated cell populations in the intestinal epithelium and lamina propria and are present in focal aggregates forming lymphoid follicles. Ultrastructural investigation has played a major role in understanding the cellular interactions and cytoarchitectural details critical to function of the mucosal immune system (1–3). The lymphoid tissue of the intestinal tract, which includes that tissue present in the oral cavity, pharynx, Peyer’s patches, appendix, and isolated follicles in the small and large intestines, represents a substantial fraction of the lymphoid elements which make up the immune system. Collectively, these immunologic structures, termed gut-associated lymphoid tissues (GALT), present a large surface area to a variety of potential antigens and respond in a highly coordinated fashion during the recognition of foreign molecules and pathogens. The distribution of lymphoid cells reflects varying antigen load in different regions of the intestine. Lymphoid tissue is prominent in the oropharynx, minimal in the esophagus and stomach, where rapid transit time and acid secretions reduce the antigenic burden, and becomes abundant again in the distal small intestine and the large intestine, where stasis promotes bacterial proliferation.

Keywords

Germinal Center Lymphoid Follicle Mucosal Immune System Recurrent Tonsillitis Lymphoid Nodule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishing, Boston 1988

Authors and Affiliations

  • Jacques Pappo
    • 1
  • Robert L. Owen
  1. 1.Cell Biology and Aging Section (151E)Veterans Administration Medical CencterSan FranciscoUSA

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