Abstract
The mechanisms by which diuretics cause vasodilation in hypertension associated with early renal disease are still not completely understood. Reduction of the expanded extracellular fluid volume and removal of accumulated sodium are undoubtedly vital elements in their therapeutic profile (1,2). Nevertheless, the dissociation between the natriuretic and hypotensive efficacy of a thiazide diuretic in patients with severe renal failure points to additional extrarenal factors (3). Moreover, the diuretic-aggravated release of renin can be expected to oppose the blood pressure lowering effects of these agents.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Wollam, G.K., Tarazi, R.C., Bravo, E.L., Dustan, H.P.: Am J Med 79, 929–938, 1982
Schiffl, H., Weidmann, P., Beretta-Piccoli, C., Cottier, C., Seiler, A.J., Ziegler W.H.: Eur J Clin Pharmacol 23, 215–220, 1982
Jones, B., Nanra, R.S.: Lancet 2, 1258–1260, 1979
Beretta-Piccoli, C., Weidmann, P., Schiffl, H., Cottier, C., Reubi, F.C.: Kidney Int 22, 297–303, 1982
Schiffl, H., Weidmann, P., Beretta-Piccoli, C., Cottier, C., Mordasini, R., Riesen, W., Ziegler, W.H.: Clin Nephrol 19 (Suppl 1), 101–108, 1983
Zimlichman, R.R., Chamovitz, C., Chaichenco, Y., Goligorsky, M., Rapaport, J., Kaplanski, J.: Clin Sci 67, 161–166, 1984
Huot, S.J., Pamnani, M.B., Clough, O.L., Buggy, J., Bryant, N.J., Harder, U.K., Haddy, F.J.: Hypertension 5 (Supp I) I-94–I-100, 1983
Wilson, T.W.: Clin Pharmacol Ther 39, 94–101, 1986
O’Connor, O.T., Preston, R.A., Mitas, J.A., Frigon, R.P., Stone, R.A.: Hypertension 3, 139–147, 1981
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Martinus Nijhoff Publishing, Boston
About this chapter
Cite this chapter
Schiffl, H. (1987). Modifications in Cardiovascular Norepinephrine Responsiveness by Diuretic Treatment in Mild Renal Parenchymal Disease. In: Andreucci, V.E., Dal Canton, A. (eds) Diuretics: Basic, Pharmacological, and Clinical Aspects. Developments in Nephrology, vol 18. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2067-8_64
Download citation
DOI: https://doi.org/10.1007/978-1-4613-2067-8_64
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-9227-2
Online ISBN: 978-1-4613-2067-8
eBook Packages: Springer Book Archive