The Anti-Antidiuretic Effect of a Stable Prostaglandin-E2 Analog in Conscious Sheep and Man
The syndrome of inappropriate antidiuretic hormone release (SIADH), also referred to as the Schwartz-Bartters syndrome is characterized by too high levels of circulating antidiuretic hormone (ADH) in relation to the actual fluidbalance of the organism. The inadequately high plasmalevel of ADH (p-ADH) produces the triad water retention, dilutional hyponatremia and increased renal Na -excretion which is typical for the syndrome (1–2). This is of clinical importance as various causes, among others nausea, arterial hypotension and artificial ventilation may induce 10 to 1000–fold increases in the normal (1–5 pg/ml) plasmalevels of ADH (2). The hazards of a reduced plasma sodium (p-Na+) were beautifully illustrated in a recent large study by Anderson et col (3). These investigators found that a p-Na+ below 130 mmol/1 caused a severalfold increase in the mortallity rate of a large population of hospitalized patients.
KeywordsUrine Osmolality Arterial Hypotension Recent Large Study Karolinska Hospital Diuretic Agent
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