The Anti-Antidiuretic Effect of a Stable Prostaglandin-E2 Analog in Conscious Sheep and Man

  • L. G. Leksell
  • C.-J. Wallin
Part of the Developments in Nephrology book series (DINE, volume 18)


The syndrome of inappropriate antidiuretic hormone release (SIADH), also referred to as the Schwartz-Bartters syndrome is characterized by too high levels of circulating antidiuretic hormone (ADH) in relation to the actual fluidbalance of the organism. The inadequately high plasmalevel of ADH (p-ADH) produces the triad water retention, dilutional hyponatremia and increased renal Na -excretion which is typical for the syndrome (1–2). This is of clinical importance as various causes, among others nausea, arterial hypotension and artificial ventilation may induce 10 to 1000–fold increases in the normal (1–5 pg/ml) plasmalevels of ADH (2). The hazards of a reduced plasma sodium (p-Na+) were beautifully illustrated in a recent large study by Anderson et col (3). These investigators found that a p-Na+ below 130 mmol/1 caused a severalfold increase in the mortallity rate of a large population of hospitalized patients.


Urine Osmolality Arterial Hypotension Recent Large Study Karolinska Hospital Diuretic Agent 
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  1. 1.
    Bartter, F.C. and Schwartz W.B. Am. J. Med. 42:790–806, 1967.PubMedCrossRefGoogle Scholar
  2. 2.
    Robertson, G.L. J. Lab. Clin. Med. 101: 331–371, 1983.Google Scholar
  3. 3.
    Anderson, R.J.,Chung, H-M.,Kluge, R. and Sehrier, R. Ann. Intern.Med. 102:164–168, 1985.Google Scholar
  4. 4.
    Lipson, L.C. and Sharp, G.W.G. Am. J. Physiol. 220: 1046–1052, 1971.PubMedGoogle Scholar
  5. 5.
    Grantham, J. and Orloff, J. J. Clin. Invest. 47:1154–1161, 1968.CrossRefGoogle Scholar
  6. 6.
    Johnston, H.H., Herzog, J.P. and Lauler, D.P. Am. J. Physiol. 213: 939–946, 1967.PubMedGoogle Scholar
  7. 7.
    Christensen, N.J., Bygdeman, M., Green, K., Jonasson, H., Rundgren, M., Wallin, C-J., Vesterqvist, O. and Leksell, L.G. Pflüg. Arch. 402:360–363, 1984.CrossRefGoogle Scholar
  8. 8.
    Leksell, L.G., Christensen, N., Vesterqvist, O. and Wallin, C-J. Clin. Physiol. 4: 449–459., 1984.PubMedCrossRefGoogle Scholar
  9. 9.
    Bygdeman, M., Bremme, K., Christensen, N., Lundström, V. and Green, K. Contraception. 22(5):471–483, 1980.PubMedCrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • L. G. Leksell
    • 1
  • C.-J. Wallin
    • 1
  1. 1.Department of Anesthesiology and department of Physiology IKarolinska InstitutetStockholmSweden

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