Dose Dependence of Inhibition of Proximal Tubular Sodium Reabsorption by Furosemide in Conscious Rats
The loop diuretic furosemide (*Fur) exerts its major diuretic effect by inhibiting NaCl reabsorption in the thick ascending limb of Henle. However, many studies have suggested an additional effect of Fur on proximal tubular Na reabsorption, in particular when care was taken to minimize changes in renal hemodynamics due to diuretic-induced volume contraction (1). Very little is known about the dose dependence of the proximal effect of Fur, so this was investigated by clearance technique in conscious rats, using the renal lithium clearance as a measure for the delivery of Na out of the proximal tubule (2).
KeywordsCatheter High Performance Liquid Chromatography Filtration Lithium Resis
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- 3.Goldberg, M. In: Hand book of Physiology, Sect. 8: Renal Physiology (Eds. J. Orloff, R.W. Berliner and S.R. Geiger) Waverly Press, Baltimore 1973, pp. 1003-1031.Google Scholar