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Dose Dependence of Inhibition of Proximal Tubular Sodium Reabsorption by Furosemide in Conscious Rats

  • S. Christensen
  • J. S. Petersen
  • E. Steiness
  • F. Andreasen
Chapter
Part of the Developments in Nephrology book series (DINE, volume 18)

Abstract

The loop diuretic furosemide (*Fur) exerts its major diuretic effect by inhibiting NaCl reabsorption in the thick ascending limb of Henle. However, many studies have suggested an additional effect of Fur on proximal tubular Na reabsorption, in particular when care was taken to minimize changes in renal hemodynamics due to diuretic-induced volume contraction (1). Very little is known about the dose dependence of the proximal effect of Fur, so this was investigated by clearance technique in conscious rats, using the renal lithium clearance as a measure for the delivery of Na out of the proximal tubule (2).

Keywords

Proximal Tubule Dose Dependence Proximal Effect Urinary Sodium Excretion Renal Hemodynamic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

Fur

furosemide;

GFR

filtration rate;

C

clearance;

U

urine concentration;

V

urine volume;

FE

fractional excretion;

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References

  1. 1.
    Seely, J.F., Dirks, J.H. Kidney Int. 11: 1–8, 1977.PubMedCrossRefGoogle Scholar
  2. 2.
    Thomsen, K. Nephron 37: 217–223, 1984.PubMedCrossRefGoogle Scholar
  3. 3.
    Goldberg, M. In: Hand book of Physiology, Sect. 8: Renal Physiology (Eds. J. Orloff, R.W. Berliner and S.R. Geiger) Waverly Press, Baltimore 1973, pp. 1003-1031.Google Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • S. Christensen
    • 1
  • J. S. Petersen
    • 1
  • E. Steiness
    • 1
  • F. Andreasen
    • 2
  1. 1.Department of PharmacologyUniversity of CopenhagenCopenhagenDenmark
  2. 2.Department of PharmacologyUniversity of AarhusAarhusDenmark

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