Effect of Muzolimine on Prostaglandin E2 Synthesis and Catabolism in Rat Kidney

  • L. Calo’
  • S. Cantaro
  • A. Vianello
  • A. Antonello
  • A. Borsatti
Part of the Developments in Nephrology book series (DINE, volume 18)


A stimulatory effect of loop diuretics on renal prostaglandin production has been clearly estabilished (1–5) and this has been considered as one of the mechanisms of their pharmacological action. The way by wich the increase of urinary prostaglandin E2 (PGE2) takes place is probably due both to an inhibition of PGE2 catabolism (6,7) and to a stimulation of Phospholipase A2 (PLA2) activity in kidney tissue (8,9).


Kidney Tissue Loop Diuretic PGE2 Production Significant Inverse Correlation PLA2 Activity 
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Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • L. Calo’
    • 1
  • S. Cantaro
    • 1
  • A. Vianello
    • 1
  • A. Antonello
    • 1
  • A. Borsatti
    • 1
  1. 1.Institute of Internal Medicine, Postgraduate School of NephrologyUniversity of PadovaPadovaItaly

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