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Kaliuresis Induced by Various Diuretics

  • W. P. Leary
  • A. J. Reyes
Chapter
Part of the Developments in Nephrology book series (DINE, volume 18)

Abstract

Single doses of placebo and of various commonly used K+-loosing diuretic formulations were randomly and double blind administered to healthy volunteers kept in a metabolic ward. All studied formulations increased mean 24-hr natriuresis significantly; early distal tubular diuretics increased mean 24-hr urinary Na+ and K+ outputs more than loop diuretics. Both types of diuretic yielded undistinguishable ranges of mean 24-hr urinary K+/Na+ ratio. Diuretic-induced 24-hr natriuresis, in subjects with normal Na+ turnover, would depend on the type of substance used (loop or early distal tubular diuretic) for a given Na+ and K+ diet. In the same circumstances urinary K+ losses would depend more on the absolute amount of Na+ mobilized by a diuretic than on the drug specimen used.

Keywords

Healthy Volunteer Single Dose Clinical Pharmacology Urinary Output Absolute Amount 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Reyes, A.J. and Leary, W.P. Curr. Ther. Res. 30: 227–235, 1981.Google Scholar
  2. 2.
    Roberts, C.J.C. and Daneshmend, T.K. Br. J. Clin. Pharmacol. 12: 465–474, 1981.PubMedGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • W. P. Leary
    • 1
  • A. J. Reyes
    • 2
  1. 1.Department of Experimental and Clinical PharmacologyUniversity of NatalDurbanSouth Africa
  2. 2.Departamento de Investigación CardiovascularFundación ProcardiasMontevideoUruguay

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