Kaliuresis Induced by Various Diuretics
Single doses of placebo and of various commonly used K+-loosing diuretic formulations were randomly and double blind administered to healthy volunteers kept in a metabolic ward. All studied formulations increased mean 24-hr natriuresis significantly; early distal tubular diuretics increased mean 24-hr urinary Na+ and K+ outputs more than loop diuretics. Both types of diuretic yielded undistinguishable ranges of mean 24-hr urinary K+/Na+ ratio. Diuretic-induced 24-hr natriuresis, in subjects with normal Na+ turnover, would depend on the type of substance used (loop or early distal tubular diuretic) for a given Na+ and K+ diet. In the same circumstances urinary K+ losses would depend more on the absolute amount of Na+ mobilized by a diuretic than on the drug specimen used.
KeywordsHealthy Volunteer Single Dose Clinical Pharmacology Urinary Output Absolute Amount
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