Kaliuresis Induced by Various Diuretics

  • W. P. Leary
  • A. J. Reyes
Part of the Developments in Nephrology book series (DINE, volume 18)


Single doses of placebo and of various commonly used K+-loosing diuretic formulations were randomly and double blind administered to healthy volunteers kept in a metabolic ward. All studied formulations increased mean 24-hr natriuresis significantly; early distal tubular diuretics increased mean 24-hr urinary Na+ and K+ outputs more than loop diuretics. Both types of diuretic yielded undistinguishable ranges of mean 24-hr urinary K+/Na+ ratio. Diuretic-induced 24-hr natriuresis, in subjects with normal Na+ turnover, would depend on the type of substance used (loop or early distal tubular diuretic) for a given Na+ and K+ diet. In the same circumstances urinary K+ losses would depend more on the absolute amount of Na+ mobilized by a diuretic than on the drug specimen used.


Healthy Volunteer Single Dose Clinical Pharmacology Urinary Output Absolute Amount 
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    Reyes, A.J. and Leary, W.P. Curr. Ther. Res. 30: 227–235, 1981.Google Scholar
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    Roberts, C.J.C. and Daneshmend, T.K. Br. J. Clin. Pharmacol. 12: 465–474, 1981.PubMedGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • W. P. Leary
    • 1
  • A. J. Reyes
    • 2
  1. 1.Department of Experimental and Clinical PharmacologyUniversity of NatalDurbanSouth Africa
  2. 2.Departamento de Investigación CardiovascularFundación ProcardiasMontevideoUruguay

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