Polyneuropathies associated with plasma cell dyscrasias are interesting and have an importance beyond their frequency for several reasons. First of all, a thorough knowledge of the natural history and laboratory features of these previously obscure disorders, as stressed in the preceding chapters, allows their recognition by clinicians. Secondly, in some cases, with recognition, specific therapy can be directed at the underlying plasma cell dyscrasia with clinical improvement. In other cases, recognition of a characteristic neuropathy suggests the presence of an unrecognized plasma cell dyscrasia, diagnosis of which may provide prognostic information and aid treatment. Finally, and perhaps most importantly, these neuropathies provide clues to the pathogenesis of obscure medical and neurologic syndromes which arise secondary to other diseases, usually malignancies, which produce secretory products harmful to neural and other tissues. Thus, a thorough understanding of these disorders will allow us to devise more effective therapy and expand our knowledge of similar diseases.
KeywordsPlasma Cell Familial Mediterranean Fever Secretory Product Neurologic Syndrome Monoclonal Protein