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Future Directions

  • John J. KellyJr.
Part of the Topics in the Neurosciences book series (TNSC, volume 5)

Abstract

Polyneuropathies associated with plasma cell dyscrasias are interesting and have an importance beyond their frequency for several reasons. First of all, a thorough knowledge of the natural history and laboratory features of these previously obscure disorders, as stressed in the preceding chapters, allows their recognition by clinicians. Secondly, in some cases, with recognition, specific therapy can be directed at the underlying plasma cell dyscrasia with clinical improvement. In other cases, recognition of a characteristic neuropathy suggests the presence of an unrecognized plasma cell dyscrasia, diagnosis of which may provide prognostic information and aid treatment. Finally, and perhaps most importantly, these neuropathies provide clues to the pathogenesis of obscure medical and neurologic syndromes which arise secondary to other diseases, usually malignancies, which produce secretory products harmful to neural and other tissues. Thus, a thorough understanding of these disorders will allow us to devise more effective therapy and expand our knowledge of similar diseases.

Keywords

Plasma Cell Familial Mediterranean Fever Secretory Product Neurologic Syndrome Monoclonal Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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    Shirahama T, Cohen AS: Blockage of amyloid induction by colchicine in an animal model. J Exp Med Sci 140:1102–1107, 1974.CrossRefGoogle Scholar
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    Zemer D, Pras M, Schar E, et al: Colchicine in the prevention and treatment of the amyloidosis of familial Mediterranean fever. New Eng J Med 314:1001–1005, 1986.PubMedCrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • John J. KellyJr.
    • 1
  1. 1.Electromyography Laboratory, Department of NeurologyTufts-New England Medical CenterBostonUSA

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