MDL-17,043, a new drug combining positive inotropic and peripheral vasodilatory properties, was found to be effective in treatment of congestive heart failure. It is available in intravenous as well as oral forms. Until its introduction, the overall hemodynamic effects of MDL-17,043 could have been achieved only with a combination of conventional agents. It therefore simplifies therapy in congestive heart failure and may improve elderly patients’ compliance. Since the mechanism of the positive inotropic effect of MDL-17,043 differs from those of digitalis glycosides and sympathomimetic amines, it is possible that unlike these agents the effect of MDL-17,043 will not decline with age.
KeywordsCongestive Heart Failure Cardiac Index Systemic Vascular Resistance Pulmonary Capillary Wedge Pressure Hemodynamic Effect
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