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Role of preclinical pharmacology in phase I clinical trials: Considerations of schedule-dependence

  • Jerry M. Collins
  • Brian Leyland-Jones
  • Charles K. Grieshaber
Part of the Cancer Treatment and Research book series (CTAR, volume 36)

Abstract

Antitumor activity or host toxicity can be increased or decreased by changing the rate of drug delivery. This phenomenon is known as schedule-dependence, and the most familiar examples occur with the use of methotrexate (MTX), fluorodeoxyuridine (FdUrd), and cytosine arabinoside (ara-C). The general motivation for the study of schedule-dependence is to improve the therapeutic index of a drug, i.e., to maximize the ratio of therapeutic effects to toxic effects.

Keywords

Continuous Infusion Maximum Tolerable Dose Bolus Dose Antitumor Efficacy Cytosine Arabinoside 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishers, Boston 1987

Authors and Affiliations

  • Jerry M. Collins
  • Brian Leyland-Jones
  • Charles K. Grieshaber

There are no affiliations available

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