Skip to main content
SpringerLink
Log in
Book cover

Pharmacological Aspects of Heart Disease pp 97–107Cite as

Interaction of Calcium Entry Blockers and Adrenergic System in Hypertension and Heart Failure

  • Chapter

  • 35 Accesses

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 68))

Abstract

Intracellular calcium plays a pivotal role in the maintenance of smooth muscle tone (1). It was not surprising therefore that calcium entry blockers have met a widespread success in the treatment of hypertension, a disease characterized by peripheral arteriolar vasoconstriction (2). However, it was soon found that the antihypertensive action of calcium entry blockers was due not only to the peripheral vasodilation (3–7) but also to other effects including natriuresis (8–10) and alteration of autonomic nervous system (11,12). Despite this multifaceted antihypertensive effect, the ability to reduce peripheral vascular resistance remained the most widely recognized mediator of blood pressure control by this class of drugs. Not only peripheral vascular resistance was found to be reduced during therapy with various CEB, but also forearm blood flow increased significantly after acute and chronic nifedipine treatment (13). It is the mechanism by which this decrease in vascular smooth muscle tone is achieved that needs further explanation.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Rasmussen, H. Ann. Intern. Med. 98 (Pt. 2): 809–816, 1983.

    PubMed  CAS  Google Scholar 

  2. Tarazi, R.C., Ibrahim, M.M., Dustan, H.P. and Ferrario, C.M. Circ. Res. (Suppl. I) 34: 213–221, 1974.

    Google Scholar 

  3. Aoki, K., Kondo, S., Mochizuki, A., Yoshida T., Kato, S., and Takikawa, K. Am. Heart J. 96: 218–226, 1978.

    Article  PubMed  CAS  Google Scholar 

  4. Olivari, M.T., Bartorelli, C., Polese, A., Fiorentini, C., Maruzzi, P., and Guazzi, M. Circulation 59: 1056–1062, 1979.

    PubMed  CAS  Google Scholar 

  5. Pederson, O.L. Acta Pharmacol. Toxicol. 49 (Suppl. II): 1, 1981.

    Google Scholar 

  6. Fouad, F.M., Aboul-Khair, M., Tarazi, R.C. J. Cardiovasc. Pharmacol. 4: S383–S386, 1982.

    Article  PubMed  Google Scholar 

  7. Tarazi, R.C, Aboul-Khair, M., and Kobayashi, K. In: Nitrendipine (Eds. A. Scriabine, S. Vanov, and K. Deck), Urban and Schwarzenberg, Baltimore-Munich, 1983, pp. 251–270.

    Google Scholar 

  8. Leonetti, G., Cuspidi, C., Smapieri, L., Terzoli, L., Zanchetti, A. J. Cardiovasc. Pharmacol. 4: S319–S324, 1982.

    Article  PubMed  Google Scholar 

  9. Garthoff, B., Knorr, A., Thomas, G., Kazda, S. Biochem, Pharmacol. 18: 3015–3016, 1982.

    Article  Google Scholar 

  10. Luft, F.C., Aronoff, G.R., Sloan, R.S., Fineberg, N.S., and Weinberger, M.H. Hypertension 7: 438–442, 1985.

    PubMed  CAS  Google Scholar 

  11. Henry, P.D. In: Calcium Blockers, Mechanisms of Action and Clinical Applications (Eds. S.F. Flaim and R. Zelis), Urban & Schwarzenberg, Baltimore-Munich, 1982, pp 135

    Google Scholar 

  12. McLeay, R.A.B., Stallard, T.J.,Watson, R.D.S., and Littler, W.A. Circulation 67: 1084, 1983.

    Article  PubMed  CAS  Google Scholar 

  13. Pederson, L.O., Mikkelsen, E. Eur. J. Clin. Pharmacol. 14: 375, 1978.

    Article  Google Scholar 

  14. Fleckenstein, A. Calcium Antagonism in Heart and Smooth Muscle, John Wiley & Sons, New York, 1983, pp. 209–285.

    Google Scholar 

  15. Casteels, R. Chest 78 (Suppl.): 150, 1978.

    Google Scholar 

  16. Van Breemen, C., Aaronson, P., Loutzenhiser, R., Meisheri, K. Chest 78 (Suppl.): 157, 1978.

    Google Scholar 

  17. Van Meel, J.C.A., De Jonge, A., Kalkman, H.O., Willfert, B., Timmermans, P.B.M.W.M., Van Zwieten, P.A. Eur. J. Pharmacol. 69: 205–208, 1981a.

    Article  PubMed  Google Scholar 

  18. Van Zwieten, P.A.,Van Meel, J.C.A. and Timmermans, P.B.M.W.M. Hypertension 5 (Suppl. II): 8–17, 1983.

    Google Scholar 

  19. Pedrinelli, R. and Tarazi, R.C. Circulation 69: 1171–1176, 1984.

    Article  PubMed  CAS  Google Scholar 

  20. Pedrinelli, R. and Tarazi, R.C. J. Pharm. & Exp. Therap. 233: 643–649, 1985.

    CAS  Google Scholar 

  21. Cauvin, C., Loutzenhiser, R., Hwang, O. and Van Breeman, C. Eur. J. Pharmacol. 84: 233–235, 1982.

    Article  PubMed  CAS  Google Scholar 

  22. Awad, R., Payne, R. and Deth, R.C. J. Pharmacol. & Exp Therap. 227: 60–67 1983.

    CAS  Google Scholar 

  23. Janssens, W. and Verhaeghe, R. J. Physiol. (London) 347: 525–532, 1984.

    CAS  Google Scholar 

  24. DeMey, J. and Vanhoutte, P.M. Circ. Res. 48: 875–884, 1981.

    CAS  Google Scholar 

  25. Muller-Schweinitzer, E. Naunyn-Schiedeberg’s Arch. Pharmacol. 324: 64–69, 1983.

    Article  CAS  Google Scholar 

  26. Beckering, J.J., Thoolen, M.J.M.C., De Jonge, A., Willfert, B., Timmermans, P.B.M.W.M., and Van Zwieten, P.A. J. Pharmacol. Exp. Therap. 229: 515–521, 1984.

    Google Scholar 

  27. Langer, S.Z., Shepperson, N.B. Br. J. Pharmacol. 74: 942, 1981.

    Google Scholar 

  28. Van Meel, J.C.A., De Zoeten, K., Timmermans, P.B.M.W., Van Zwieten, P.A. J. Auton. Pharmacol. 2: 13, 1982.

    Article  PubMed  Google Scholar 

  29. Timmermans, P.B.M.W., De Jonge, A., Van Meel, J.C.A., Mathy, M.J., and Van Zwieten, P.A. J. Cardiovasc. Pharmacol. 5: 1, 1983.

    Article  PubMed  CAS  Google Scholar 

  30. Llenas S. and Massingham, R. Eur. J. Pharmacol. 87: 53, 1983.

    Article  PubMed  CAS  Google Scholar 

  31. Kobinger, W., Lillie, C. and Pichler, L. Circ. Res. (Suppl. 1) 46: 21–25, 1980.

    CAS  Google Scholar 

  32. Folkow, B. Circulation 21: 760–768, 1960.

    PubMed  CAS  Google Scholar 

  33. Guazzi, M.D., Fiorentini, C., Olivari, M.T., Bartorelli, A., Necchi, G. and Polese, A. Circulation 61, 913–919, 1980.

    PubMed  CAS  Google Scholar 

  34. Fouad, F.A., Pedrinelli, R., Bravo, E.L., Abi-Samra, F., Textor, S.C. and Tarazi, R.C. Clin. Pharmacol. & Therap. 35: 768–775, 1984.

    Article  CAS  Google Scholar 

  35. Brown, A.M. Circ. Res. 46: 1–10, 1980.

    PubMed  CAS  Google Scholar 

  36. Watson, R.D.S., Stallard, T.J. and Littler, W.A. Clin. Sci. 57: 241, 1979.

    PubMed  CAS  Google Scholar 

  37. Millard, E.W., Lathrop, D.A., Grupp, G., Ashraf, M., Grupp, I.L. and Schwartz, A. Am. J. Cardiol. 49: 499–505, 1982.

    Article  PubMed  CAS  Google Scholar 

  38. Tarazi, R.C. Cardiovasc. Med. 3: 1125–1131, 1978.

    Google Scholar 

  39. Tarazi, R.C. and Fouad, F.M. J. Hypertension 3 (Suppl. 2): S27–32, 1985.

    CAS  Google Scholar 

  40. Kazda, S., Garthoff, B., Meyer, H., Schlossmann, K., Stoepel, K., Towart, R., Vater, W. and Wehinger, E. Arzneim, Fosch. 30: 2144–2162, 1980.

    CAS  Google Scholar 

  41. Triggle, D.J. In: New Perspectives on Calcium Antagonists (Ed. G.B. Weiss), American Physiological Society, Bethesda, 1981, pp. 1–18.

    Google Scholar 

  42. Dargie, H., Rowland E. E. and Krickler, D. Br. Heart J. 468: 8–16, 1981.

    Article  Google Scholar 

  43. Leon M.B., Rosing, D.R., Bonow, R.O., Lipson, L.C. and Epstein, S.E. Am. J. Cardiol. 48: 131–139, 1981.

    Article  PubMed  CAS  Google Scholar 

  44. Bela Subramanian, V., Bowles, M.J., Davies, A.B. and Raftery, E.B. Am. J. Cardiol. 49: 125–132, 1982.

    Article  PubMed  CAS  Google Scholar 

  45. Goldstein, R.E., Beiser, G.D., Stampfer, M. and Epstein, S.E. Circ. Res. 36: 571–578, 1975.

    PubMed  CAS  Google Scholar 

  46. Fifer, M.A., Colucci, W.S., Lorell, B.H., Jaski, B.E. and Barry, W.H. J. Am. Coll. Cardiol. 5: 731–737, 1985.

    Article  CAS  Google Scholar 

  47. Elkayam, U., Weber, L., Torkan, B., Berman, D. and Rahimtoola, S.H. Am. J. Cardiol. 52: 1041–1045, 1983.

    Article  PubMed  CAS  Google Scholar 

  48. Prida, X.E., Kubo, S.H., Laragh, J.H. and Cody, R.J. Am. J. Med. 75: 795–800, 1983.

    Article  PubMed  CAS  Google Scholar 

  49. Miller, A.B., Conetta, D.A. and Bass, T.A. Am. J. Cardiol. 55: 1359–1362, 1980.

    Article  Google Scholar 

  50. Olivari, M.T., Levine, T.B. and Cohn, J.N. J. Cardiovasc. Pharmacol. 6 (Suppl. 7): S1002–S1005, 1984.

    Article  PubMed  Google Scholar 

  51. Kubu, S.H., Fox, S.C, Prida, X.E. and Cody, R.J. Am. Heart J. 10: 1032–1034, 1985.

    Article  Google Scholar 

  52. Lahiri, A., Tovey, J., Kohli, R.S., Robinson, C.W., Caruana, M.P., Harlow, B.J. and Raftery, E.B. Postgraduate Med. Journal 60 (Suppl 4): 35–38, 1984.

    Google Scholar 

  53. Given, B.D., Lee, T.H., Stone, P.H. and Dzau, V.J. Arch. Intern. Med. 145: 281–285, 1985.

    Article  PubMed  CAS  Google Scholar 

  54. Tweddel, A.C. and Hutton, I. Eur. Heart J. 7: 54–60, 1986.

    PubMed  CAS  Google Scholar 

  55. Kobayashi, K. and Tarazi, R.C. Hypertension 5 (Suppl II): II-45 - II-51, 1983.

    CAS  Google Scholar 

  56. Cantelli, I., Pavesi, P.C., Parchi, C, Naccarella, F. and Bracchetti, D. Am. Heart J. 106: 308–315, 1983.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Heart and Hypertension, Research Institute of The Cleveland Clinic Foundation, Cleveland, Ohio, USA

    F. Fouad-Tarazi & R. Pedrinelli

  2. Clinica Medica Generale e Terapia, Universita di Pisa, Pisa, Italy

    F. Fouad-Tarazi & R. Pedrinelli

Authors
  1. F. Fouad-Tarazi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Pedrinelli
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Youville Research Institute, St. Boniface General Hospital and Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Robert E. Beamish , Vincenzo Panagia  & Naranjan S. Dhalla ,  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Martinus Nijhoff Publishing, Boston

About this chapter

Cite this chapter

Fouad-Tarazi, F., Pedrinelli, R. (1987). Interaction of Calcium Entry Blockers and Adrenergic System in Hypertension and Heart Failure. In: Beamish, R.E., Panagia, V., Dhalla, N.S. (eds) Pharmacological Aspects of Heart Disease. Developments in Cardiovascular Medicine, vol 68. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2057-9_8

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2057-9_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9222-7

  • Online ISBN: 978-1-4613-2057-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation