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Protective Effect of Nifedipine upon Ouabain-Induced Arrhythmias

  • Chapter
Pharmacological Aspects of Heart Disease

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 68))

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Abstract

Calcium channel blockers represent a group of compounds which have the common property of inhibiting transmembrane calcium influx via the voltage gated channels (1). Recent reports suggest the existence of a kinetic interaction between calcium channel blockers and cardiac glycosides which leads to the elevation of plasma digoxin level (2–4). This phenomena is partly attributed to the reduced renal clearance of digitalis (5).

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Author information

Authors and Affiliations

  1. Departments of Medicine and Pharmacology, Section of Cardiology, University of Manitoba, R3E 0Z3, Winnipeg, Canada

    S. Navaratnam & J. C. Khatter

Authors
  1. S. Navaratnam
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  2. J. C. Khatter
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Editor information

Editors and Affiliations

  1. Youville Research Institute, St. Boniface General Hospital and Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Robert E. Beamish , Vincenzo Panagia  & Naranjan S. Dhalla ,  & 

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© 1987 Martinus Nijhoff Publishing, Boston

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Navaratnam, S., Khatter, J.C. (1987). Protective Effect of Nifedipine upon Ouabain-Induced Arrhythmias. In: Beamish, R.E., Panagia, V., Dhalla, N.S. (eds) Pharmacological Aspects of Heart Disease. Developments in Cardiovascular Medicine, vol 68. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2057-9_5

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  • DOI: https://doi.org/10.1007/978-1-4613-2057-9_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9222-7

  • Online ISBN: 978-1-4613-2057-9

  • eBook Packages: Springer Book Archive

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