Skip to main content
SpringerLink
Log in

Antiarrhythmic Drug Therapy for Patients with Ventricular Tachyarrhythmias in the Setting of Left Ventricular Dysfunction: 1. The Role of Propafenone 2. The Role of Adjunct Beta-Blockade

  • Chapter
Pharmacological Aspects of Heart Disease

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 68))

  • 35 Accesses

Abstract

The isolated occurrence of either congestive heart failure or ventricular tachycardia (VT) carries a poor prognosis. Frequently, congestive heart failure and complex ventricular arrhythmia coexist in patients (1–5). The combined occurrence of congestive heart failure and complex ventricular arrhythmia has a worse prognosis than either alone, with an annual reported mortality of between 50 and 60 percent (2). Previous attempts at extending survival in this group of patients has primarily focused on treatment of heart failure (1,2). Despite control of heart failure, mortality remained high as patients frequently succumbed to sudden death. However, previous investigators have not pursued aggressive arrhythmia management in this group of patients.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Franciosa JA, Wilen M, Ziesche S, Cohn JN. Am J Cardiol 1983;51:831–836.

    Article  PubMed  CAS  Google Scholar 

  2. Wilson JR, Schwartz JS, St John Sutton M, Ferraro N, Horowitz LN, Reichek N, Josephson ME. J Am Coll Cardiol 1983;2:403–410.

    Article  PubMed  CAS  Google Scholar 

  3. Poll DS, Marchlinski FE, Buxton AE, Doherty JU, Waxman HL, Josephson ME. Circulation 1984;70:451–456.

    Article  PubMed  CAS  Google Scholar 

  4. Swerdlow CD, Winkle RA, Mason JW. N Engl J Med 1983;308:1436–1442.

    Article  PubMed  CAS  Google Scholar 

  5. Roy D, Waxman HL, Kienzle MG, Buxton AE, Marchlinski FE, Josephson ME. Am J Cardiol 1983;52:969–974.

    Article  PubMed  CAS  Google Scholar 

  6. Graboys TB, Lown B, Podrid PJ, DeSilva R. Am J Cardiol 1982;50:437–443.

    Article  PubMed  CAS  Google Scholar 

  7. Podrid P, Schoeneberger A, Lown B. N Engl J Med 1980;302:614.

    Article  PubMed  CAS  Google Scholar 

  8. Smitherman TC, Gottlich CM, Narahara KA, Osborn RC, Piatt M, Rude RE, Lepscomb K. Chest 1979;76:552–556.

    Article  PubMed  CAS  Google Scholar 

  9. Trobaugh GB, Kudenchuk PJ, Greene HI, Tutt RC, Kingston E, Gorham Jr, Gross BW, Graham EL, Sears GK, Werner, JA. Am J Cardiol 1984;54:1263–1266.

    Article  PubMed  CAS  Google Scholar 

  10. Stein J, Podrid P, Lown B. Am J Cardiol 1984;54:575–578.

    Article  PubMed  CAS  Google Scholar 

  11. McLeod AA, Stiles GL, and Shand, DG. J Pharmacol and Exp Therapeutics 1984;228:461–466.

    CAS  Google Scholar 

  12. Dukes ID, Vaughan Williams, EM. European Heart Journal 1984;5:115–125.

    PubMed  CAS  Google Scholar 

  13. Walleffe A, Mary-Rabine L, de Rijbel R, Soyeur D, Legrand V,Kulbertus HE. European Heart Journal 1981;2:345–352.

    Google Scholar 

  14. Salerno DM, Granrud G, Sharkey P, Asinger R, Hodges M. Am J Cardiol 1984;53:77–83.

    Article  PubMed  CAS  Google Scholar 

  15. Shen EN, Sung RJ, Morady F, Schwartz AB, Scheinman MM, Dicarlo L, Shapiro W. J Am Coll Cardiol 1984;3:1291–1297.

    Article  PubMed  CAS  Google Scholar 

  16. Podrid PJ, Lown B. J Am Coll Cardiol 1984;4:117–125.

    Article  PubMed  CAS  Google Scholar 

  17. Baker BJ, Dinh HA, Kroskey D, de Soyza NDB, Murphy ML, Franciosa JA. Am J Cardiol 1984;54:20D–22D.

    Article  PubMed  CAS  Google Scholar 

  18. The Norwegian Multicenter Study Group. N Engl J Med 1981;304:801–807.

    Article  Google Scholar 

  19. Coltart DJ, Gibson DG, Shand DG. British Med J 1971;1:490–491.

    Article  CAS  Google Scholar 

  20. Brodsky MA, Sato DA, Allen BJ, Chesnie BN, Henry WL. Chest 1986;89:790–794.

    Article  PubMed  CAS  Google Scholar 

  21. Hirsowitz G, Podrid P, Lampert S, Stein J, Lown B: J Am Coll Cardiol 1978;3:618.

    Google Scholar 

  22. Swedberg K, Waagstein F, Hjalmarson A, Wallentin: Lancet 1979; 1:1374–375.

    Article  PubMed  CAS  Google Scholar 

  23. Wellens HJJ, Brugada P, Stevenson WG: Circulation 1985;72:1–7.

    Article  PubMed  CAS  Google Scholar 

  24. Swiryn S, Bauernfiend RA, Strasberg B, Palileo E, Iverson N, Levy PS, Rosen KM. Am Heart J 1982;104:43–50.

    Article  PubMed  CAS  Google Scholar 

  25. Horowitz LN, Josephson ME, Farshidi A, Spellman SR, Michelson EL, Greenspan AM. Circulation 1978;58:986–997.

    PubMed  CAS  Google Scholar 

  26. Duffy CE, Swiryn S, Bauernfeind RA, Strasberg B, Pallileo E, Rosen KM. Am Heart J 1983;106:450–458.

    Article  PubMed  CAS  Google Scholar 

  27. Ross DL, Sze DY, Keefe DL, Swerdlow CD, Echt DS, Griffin JC, Winkle RA, Mason, JW. Circulation 1982;66: 1205–1210.

    Article  PubMed  CAS  Google Scholar 

  28. DiMarco J, Garan H, Ruskin J: Circulation 1980; 62:261.

    Google Scholar 

  29. Dreifus LS, Lim HR, Watanabe Y, McKnight E, Frank, Mn. JAMA 1968;204:736–737.

    Article  PubMed  CAS  Google Scholar 

  30. Fors WJ, Vanderark CR, Reynolds EW. Am J Cardiol 1971;27:190–194.

    Article  PubMed  Google Scholar 

  31. Mason JW, Winkle RA. Circulation 1978;58:971–985.

    PubMed  CAS  Google Scholar 

  32. Wit AL, Hoffman BF, Rosen MR. (Parts A,B,C). Am Heart J 1975;90:521–523, 665–675, 795–03.

    CAS  Google Scholar 

  33. Arnsdorf MF. J Pharmacol and Exp Therapeutics 1977;201:689–700.

    CAS  Google Scholar 

  34. Han J, Garcia DP, Moe GK. Circulation Res 1964;14:516–524.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cardiology Division, Department of Medicine, University of California Irvine Medical Center, 101 City Drive South, 92668, Orange, California, USA

    M. A. Brodsky, B. J. Allen, C. Luckett & R. Thomas

Authors
  1. M. A. Brodsky
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. J. Allen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. Luckett
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Thomas
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Youville Research Institute, St. Boniface General Hospital and Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Robert E. Beamish , Vincenzo Panagia  & Naranjan S. Dhalla ,  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Martinus Nijhoff Publishing, Boston

About this chapter

Cite this chapter

Brodsky, M.A., Allen, B.J., Luckett, C., Thomas, R. (1987). Antiarrhythmic Drug Therapy for Patients with Ventricular Tachyarrhythmias in the Setting of Left Ventricular Dysfunction: 1. The Role of Propafenone 2. The Role of Adjunct Beta-Blockade. In: Beamish, R.E., Panagia, V., Dhalla, N.S. (eds) Pharmacological Aspects of Heart Disease. Developments in Cardiovascular Medicine, vol 68. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2057-9_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2057-9_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9222-7

  • Online ISBN: 978-1-4613-2057-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation