Effects of Verapamil on Metabolism and Function of Hearts from Normal and Hyperthyroid Rats
That thyroid hormones sensitize the heart and other organs to the metabolic effects of catecholamines is generally accepted. A possible important factor in mediating this hypersensitivety is the intracellular concentration of calcium ions. Hartley and McNeill (1) studied the effect of calcium on cardiac metabolism and myocardial contraction in isolated, perfused hearts from hyperthyroid rats a decade ago. They reported that pretreatment of rats with triiodothyronine did not enhance the elevation in cardiac phosphorylase a activity produced by progressively increasing doses of calcium ions in the fluid perfusing the isolated rat hearts.
KeywordsLactate Production Glycogen Content Isometric Force Contractile Force Perfuse Heart
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