Effects of Verapamil on Metabolism and Function of Hearts from Normal and Hyperthyroid Rats

  • M. E. Hess
  • N. Haugaard
  • A. Torbati
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 68)


That thyroid hormones sensitize the heart and other organs to the metabolic effects of catecholamines is generally accepted. A possible important factor in mediating this hypersensitivety is the intracellular concentration of calcium ions. Hartley and McNeill (1) studied the effect of calcium on cardiac metabolism and myocardial contraction in isolated, perfused hearts from hyperthyroid rats a decade ago. They reported that pretreatment of rats with triiodothyronine did not enhance the elevation in cardiac phosphorylase a activity produced by progressively increasing doses of calcium ions in the fluid perfusing the isolated rat hearts.


Lactate Production Glycogen Content Isometric Force Contractile Force Perfuse Heart 
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Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • M. E. Hess
    • 1
  • N. Haugaard
    • 1
  • A. Torbati
    • 1
  1. 1.Department of PharmacologyUniversity of Pennsylvania, School of MedicinePhiladelphiaUSA

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