Myocardial Enzyme Leakage and Succinic Dehydrogenase Activity of Mitochondria Correlated with the Morphological Changes in the Anoxic Isolated Perfused Rat Heart

  • Jung Yeh-Chih
  • Wen Wen-Hu
  • Han Yu-Sheng
  • Fu Ling-Xiong
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 67)

Abstract

It has been shown in the previous studies(1)(2) that in the anoxic rat myocardial cells, the mitochondria show structural changes including its swelling, separation of the cristae and the vacuolization, the cell membrane permeability defects demonstrated allowing the entiy of lanthanum as a tracer into the myocardial cells. When the supply of oxygen to the heart is impaired, myocardial mitochondrial function will be influenced and the cytoplasmic constituents will leak from the anoxic myocardial cells. In the present paper, the Langendorff isolated perfused rat heart system has been used to study the myocardial enzyme leakage, i.e. creatine kinase (CPK) release, and the succinic dehydrogenase (SDH) activity of the mitochondria isolated and then to investigate their correlation with the morphological changes in the anoxic rat myocardial cells.

Keywords

Permeability Sucrose Hydrate Ischemia Heparin 

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Copyright information

© Springer Science+Business Media Dordrecht 1987

Authors and Affiliations

  • Jung Yeh-Chih
    • 1
  • Wen Wen-Hu
    • 1
  • Han Yu-Sheng
    • 2
  • Fu Ling-Xiong
    • 1
  1. 1.Department of Internal MedicineHsin-Hua HospitalShanghaiChina
  2. 2.Department of Bio-physicsShanghai Second Medical UniversityShanghaiChina

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