Advertisement

Remodelling of the Myocyte at a Molecular Level — Relationship Between Myosin Isoenzyme Population and Sarcoplasmic Reticulum

  • H. Rupp
  • R. Wahl
  • R. Jacob
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 66)

Abstract

There is increasing evidence that the molecular structure of the myocyte is variable, critically depending on the functional load to which the heart is subjected on a long-term basis. The potential of the myocyte to adapt its functionally important structural elements to a given load represents an important means by which the heart can cope with a variety of loads ranging from those arising during physical exercise or increased blood pressure (1). Although such remodelling of the myocyte is of great functional relevance, only little is known at present in terms of the trigger reactions involved at the cellular or molecular level. In view of the great number of variable elements of the myocyte, it is unlikely that for each one there is a selective trigger signal. Rather, it can be assumed that a given stimulus affects a number of functionally coherent structures of the myocyte in a concerted manner. An understanding of mechanisms involved in the remodelling is the prerequisite not only for a rational description of myocardial performance but also for tracing the causes of pathological processes such as decompensation of the pressure loaded heart issuing in pump failure.

Keywords

Sarcoplasmic Reticulum Trigger Reaction Concerted Manner Circulate Thyroid Hormone Concerted Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Rupp, H. (Ed.) Regulation of Heart Function - Basic Concepts and Clinical Applications, Thieme Inc., Stuttgart-New York, 1986.Google Scholar
  2. 2.
    Rupp, H. Basic Res. Cardiol. 77: 34–46, 1982.PubMedCrossRefGoogle Scholar
  3. 3.
    Rupp, H. Mol. Physiol. 3: 249–263,.1983Google Scholar
  4. 4.
    Ebrecht, G., Rupp, H. and Jacob, R. Basic Res. Cardiol. 77: 220–234, 1982.PubMedCrossRefGoogle Scholar
  5. 5.
    Schwartz, K., Lecarpentier, Y., Martin, J.L., Lompré, A.M., Mercadier, J.J. and Swynghedauw, B. J. Mol. Cell. Cardiol. 13: 1071–1075, 1981.PubMedCrossRefGoogle Scholar
  6. 6.
    Alpert, N.R. and Mulieri, L.A. In: Regulation of Heart Function — Basic Concepts and Clinical Applications (Ed. H. Rupp), Thieme Inc., Stuttgart-New York, 1986, pp. 292–304.Google Scholar
  7. 7.
    Kissling, G., Rupp, H., Malloy, L. and Jacob, R. Basic Res. Cardiol. 77: 255–269, 1982.PubMedCrossRefGoogle Scholar
  8. 8.
    Jacob, R., Ebrecht, G., Kissling, G., Rupp, H. and Takeda, N. In: Regulation of Heart Function — Basic Concepts and Clinical Applications (Ed. H. Rupp), Thieme Inc., Stuttgart-New York, 1986, pp. 305–326.Google Scholar
  9. 9.
    Fabiato, A. Am. J. Physiol. 245: C1–C14, 1983.PubMedGoogle Scholar
  10. 10.
    Hasselbach, W. and Oetliker, H. Ann. Rev. Physiol. 45: 325–339, 1983.CrossRefGoogle Scholar
  11. 11.
    Rupp, H. and Jacob, R. Can. J. Physiol. Pharmacol. 60: 1098–1103, 1982.PubMedCrossRefGoogle Scholar
  12. 12.
    Rupp, H., Felbier, H.-R., Bukhari, A.R. and Jacob, R. Can. J. Physiol. Pharmacol. 62: 1209–1218, 1984.PubMedCrossRefGoogle Scholar
  13. 13.
    Rupp, H. Basic Res. Cardiol. 80: 608–616, 1985.PubMedCrossRefGoogle Scholar
  14. 14.
    Malhotra, A., Penpargkul, S., Schaible, T. and Scheuer, J. Am. J. Physiol. 241: H263–H267, 1981.PubMedGoogle Scholar
  15. 15.
    Pagani, E.D. and Solaro, R.J. Am. J. Physiol. 247: H909–H915, 1984.PubMedGoogle Scholar
  16. 16.
    Mahdavi, V., Chambers, A.P. and Nadal-Ginard, B. Proc. Natl. Acad. Sci. USA 81: 2626–2630, 1984.PubMedCrossRefGoogle Scholar
  17. 17.
    Limas, C.J. In: Regulation of Heart Function - Basic Concepts and Clinical Applications (Ed. H. Rupp), Thieme Inc., Stuttgart-New York, 1986, pp. 145–158.Google Scholar
  18. 18.
    Limas, C.J. and Cohn, J.N. Circ. Res. 41: I-62–I-69,1977.Google Scholar
  19. 19.
    Heilmann, C, Lindl, T., Muller, W. and Pette, D. Basic Res. Cardiol. 75: 92–96, 1980.PubMedCrossRefGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • H. Rupp
    • 1
  • R. Wahl
    • 2
  • R. Jacob
    • 1
  1. 1.Physiologisches Institut (II)Universität TübingenTübingenGermany
  2. 2.Medizinische KlinikUniversität TübingenTübingenGermany

Personalised recommendations