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Pathophysiology of Heart Disease pp 115–130Cite as

Implications of Atrial Natriuretic Factor (ANF) in the Pathogenesis of Experimental and Human Hypertension

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Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 65))

Abstract

It is now well established that the atria in mammals (1–3) and possibly the atria and ventricle in non-mammalian vertebrates (4,5) are an endocrine gland harbouring a peptide (atrial natriuretic factor, ANF) of nown composition whose cDNA and gene have been cloned (6,7). The main circulating form of ANF in the rat is the C-terminal, active portion of the molecule (Ser 99-Tyr 126) (8) while a minor circulating component is a truncated version (Ser 103-Tyr 126) (9). Secretory granules of rat atrial cardiocytes harbour the whole propeptide (Asn 1-Tyr 126) (10) and the pre portion of the peptide is made up of 24AA. The two Arg-Arg at the C-terminal end of the molecule which have been found by cloning of the cDNA and gene are not part of the circulating molecule in the rat and are not present in the human prepropeptide (1).

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Author information

Authors and Affiliations

  1. Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, H2W 1R7, Canada

    M. Cantin, R. Garcia, J. Gutkowska, G. Thibault, O. Kuchel, P. Larochelle, J. Cusson, P. Hamet, E. L. Schiffrin & J. Genest

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  1. M. Cantin
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  2. R. Garcia
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  3. J. Gutkowska
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  9. E. L. Schiffrin
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Editors and Affiliations

  1. Department of Physiology, Youville Research Institute, St. Boniface General Hospital and University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla , Pawan K. Singal  & Robert E. Beamish ,  & 

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© 1987 Martinus Nijhoff Publishing, Boston

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Cantin, M. et al. (1987). Implications of Atrial Natriuretic Factor (ANF) in the Pathogenesis of Experimental and Human Hypertension. In: Dhalla, N.S., Singal, P.K., Beamish, R.E. (eds) Pathophysiology of Heart Disease. Developments in Cardiovascular Medicine, vol 65. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2051-7_8

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  • DOI: https://doi.org/10.1007/978-1-4613-2051-7_8

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