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Implications of Atrial Natriuretic Factor (ANF) in the Pathogenesis of Experimental and Human Hypertension

  • M. Cantin
  • R. Garcia
  • J. Gutkowska
  • G. Thibault
  • O. Kuchel
  • P. Larochelle
  • J. Cusson
  • P. Hamet
  • E. L. Schiffrin
  • J. Genest
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 65)

Abstract

It is now well established that the atria in mammals (1–3) and possibly the atria and ventricle in non-mammalian vertebrates (4,5) are an endocrine gland harbouring a peptide (atrial natriuretic factor, ANF) of nown composition whose cDNA and gene have been cloned (6,7). The main circulating form of ANF in the rat is the C-terminal, active portion of the molecule (Ser 99-Tyr 126) (8) while a minor circulating component is a truncated version (Ser 103-Tyr 126) (9). Secretory granules of rat atrial cardiocytes harbour the whole propeptide (Asn 1-Tyr 126) (10) and the pre portion of the peptide is made up of 24AA. The two Arg-Arg at the C-terminal end of the molecule which have been found by cloning of the cDNA and gene are not part of the circulating molecule in the rat and are not present in the human prepropeptide (1).

Keywords

Essential Hypertension Left Atrium Renovascular Hypertension Atrial Natriuretic Factor Osmotic Minipumps 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Cantin, M. and Genest, J. Endocr. Rev. 6.107–127, 1985.PubMedCrossRefGoogle Scholar
  2. 2.
    de Bold, A.J. Science 230:767–770, 1985.PubMedCrossRefGoogle Scholar
  3. 3.
    Laragh, J.H. N. Engl. J. Med. 313:1330–1340, 1985.PubMedCrossRefGoogle Scholar
  4. 4.
    Chapeau, C, Gutkowska, J., Schiller, P.W., Milne, R.W., Thibault, G., Garcia, R., Genest, J. and Cantin, M. J. Histochem. Cytochem. 33: 541–550, 1985.PubMedCrossRefGoogle Scholar
  5. 5.
    Netchitailo, P., Feuilloley, M., Pelletier, G., Cantin, M., De Léan, A., LeBoulenger, F. and Vaudry, H. Peptides (submitted).Google Scholar
  6. 6.
    Argentin, S., Nemer, M., Drouin, J., Scott, G.N., Kennedy, B.P., Davies, P.L. J. Biol. Chem. 260:4568–4571, 1985.PubMedGoogle Scholar
  7. 7.
    Zivin, R.A., Condra, J.H., Dixon, R.A.F., Seidah, N.G., Chrétien, M., Nemer, M., Chamberland, M. and Drouin, J. Proc Natl. Acad. Sci. USA 81 6325–6329, 1984.PubMedCrossRefGoogle Scholar
  8. 8.
    Thibault, G., Lazure, C, Schiffrin, E.L., Gutkowska, J., Chrétien, L., Garcia, R., Seidah, N.G., Chretien, M., Genest, J. and Chretien, M. Biochem. Biophys. Res. Comm. 130: 981–986, 1985.PubMedCrossRefGoogle Scholar
  9. 9.
    Schwartz, P., Geller, D.M., Manning, P.T., Siegel, N.R., Fok, K.F., Smith, C.E. and Needleman, P. Science 229: 397–400. 1985.PubMedCrossRefGoogle Scholar
  10. 10.
    Thibault, G., Garcia, R., Gutkowska, J., Bilodeau, J., Lazure, C, Seidah, N.G., Chretien, M., Genest, J. and Cantin, M. J. Biol. Chem. (submitted).Google Scholar
  11. 11.
    Garcia, R., Cantin, M., De Léan, A., Genest, J., Godin, J., Gutkowska, J., Schiffrin, E.L, and Thibault, G. Biochem. Biophys. Res. Comm. 135:987–993, 1986.PubMedCrossRefGoogle Scholar
  12. 12.
    Thibault, G., Garcia, R., Schiffrin, E.L., De Léan, A., Schiller, P., Hamet, P., Gutkowska, J., Genest, J. and Cantin, M. Fed. Proc. (in press).Google Scholar
  13. 13.
    Januszewicz, P., Gutkowska, J., De Léan, A., Thibault, G., Garcia, R., Genest, J. and Cantin, M. Proc. Soc. Exp. Biol. Med. 178:321–325, 1985.PubMedGoogle Scholar
  14. 14.
    Stone, R.A. and Glembotski, C.G. Biochem. Biophys. Res. Comm. 134: 1022–1028, 1986.PubMedCrossRefGoogle Scholar
  15. 15.
    Netchitailo, P., Feuilloley, M., Pelletier, G., Leboulenger, L., Cantin, M. and Vaudry, H. Neuroscience (submitted).Google Scholar
  16. 16.
    Skofitsch, G., Jacobowitz, D.M., Eskay, R.L. and Zamir, M. Neuroscience 16:917–948, 1985.PubMedCrossRefGoogle Scholar
  17. 17.
    Debinski, B., Gutkowska, J., Kuchel, O., Racz, K., Buu, N.T., Cantin, M. and Genest, J. Science (submitted).Google Scholar
  18. 18.
    Debinski, W., Gutkowska, J., Kuchel, O., Racz, K., Buu, N.T., Cantin, M. and Genest, J. Biochem. Biophys. Res. Comm. 134:279–284, 1986.PubMedCrossRefGoogle Scholar
  19. 19.
    De Léan, A., Ong, H., McNicoll, N., Racz, K., Gutkowska, J. and Cantin, M. Life Sci. 36:2375–2382, 1985.PubMedCrossRefGoogle Scholar
  20. 20.
    Sakamoto, M., Nakao, K., Morii, N., Sugawara, A., Yamada, T., Itoh, H., Shiono, S., Saito, Y. and Imura, H. Biochem. Biophys. Res. Comm. 135: 515–520, 1986.PubMedCrossRefGoogle Scholar
  21. 21.
    Bianchi, C, Gutkowska, J., Thibault, G., Garcia, R., Genest, J. and Cantin, M. Histochemistry 82:441–452, 1985.PubMedCrossRefGoogle Scholar
  22. 22.
    Bianchi, C, Gutkowska, J., Ballak, M., Genest, J. and Cantin, M. Am. J. Physiol. (in press).Google Scholar
  23. 23.
    Bianchi, C, Gutkowska, J., Ballak, M., Charbonneau, C, Genest, J. and Cantin, M. J. Histochem. Cytochem. (submitted).Google Scholar
  24. 24.
    De Léan, A., Racz, K., Gutkowska, J., Nguyen, T.T., Cantin, M. and Genest, J. Endocrinology 115: 1636–1638, 1984.PubMedCrossRefGoogle Scholar
  25. 25.
    Bianchi, C, Anand-Srivastava, M.B., De Léan, A., Gutkowska, J., Forthomme, D., Genest, J. and Cantin, M. Current Eye Res. 5:283–293, 1986.CrossRefGoogle Scholar
  26. 26.
    Anand-Srivastava, M.B., Cantin, M. and Genest, J. Life Sci. 36: 1873–1929, 1985.PubMedCrossRefGoogle Scholar
  27. 27.
    Quirion, R., Dalpe, M., De Léan, A., Gutkowska, J., Cantin, M. and Genest, J. Peptides 5.1167–1172, 1984.PubMedCrossRefGoogle Scholar
  28. 28.
    Bianchi, C, Gutkowska, J., Ballak, M., Thibault, G., Garcia, R., Genest, J. and Cantin, M. Neuroendocrine ogy (in press).Google Scholar
  29. 29.
    Gutkowska, J., Horky, K., Schiffrin, E.L., Thibault, G., Garcia, R., De Léan, A., Hamet, P., Tremblay, J., Anand-Srivastava, M.B., Januszewicz, P., Genest, J. and Cantin, M. Fed. Proc. 45:2101–2105, 1986PubMedGoogle Scholar
  30. 30.
    Gutkowska, J., Thibault, G., Januszewicz, P., Cantin, M. and Genest, J. Biochem. Biophys. Res. Comm. 122:593–601, 1984.PubMedCrossRefGoogle Scholar
  31. 31.
    Cantin, M., Timm-Kennedy, M., El-Khatib, E., Huet, M. and Yunge, L. Anat. Rec. 193:55–76, 1979.PubMedCrossRefGoogle Scholar
  32. 32.
    Gutkowska, J., Horky, K., Thibault, G., Januszewicz, P., Cantin, M. and Genest, J. Biochem. Biophys. Res. Comm. 125:315–323, 1984.PubMedCrossRefGoogle Scholar
  33. 33.
    Horky, K., Gutkowska, J., Garcia, R., Thibault, G., Genest, J. and Cantin, M. Biochem. Biophys. Res. Comm. 129:651–657, 1985.PubMedCrossRefGoogle Scholar
  34. 34.
    Gutkowska, J., Horky K., Lachance, C, Racz, K., Garcia, R., Thibault, G., Kuchel, O., Genest, J. and Cantin, M. Hypertension 8 (Suppl. I): I-137–I-140, 1986.Google Scholar
  35. 35.
    Hi rata, Y., Ganguli, M., Tobian, L. and Iwai, J. Hypertension (Suppl. I) 6:I-148–I-155, 1984.Google Scholar
  36. 36.
    Snajdar, R.M. and Rapp, J.M. Hypertension 7:775–782, 1985.PubMedGoogle Scholar
  37. 37.
    Gutkowska, J., Kuchel, O., Racz, K., Buu, N.T., Cantin, M. and Genest, J. Biochem. Biophys. Res. Comm. (submitted).Google Scholar
  38. 38.
    Cantin, M., Gutkowska, J., Lacasse, J., Ballak, M., Ledoux, S., Inagami, T., Beuzeron, J. and Genest, J. Am. J. Path. 115:212–224, 1984.PubMedGoogle Scholar
  39. 39.
    Garcia, R., Cantin, M., Genest, J., Gutkowska, J. and Thibault, G. Hypertension (submitted).Google Scholar
  40. 40.
    Campese, V.M. Am. J. Nephrol.3:128–138, 1983.PubMedCrossRefGoogle Scholar
  41. 41.
    Racz, K., Kuchel, O., Buu, N.T. and Garcia, R. J. Hypertension (in press).Google Scholar
  42. 42.
    Debinski, w., Kuchel, O., Garcia, R., Buu, N.T., Racz, K., Cantin, M. and Genest, J. Proc. Soc. Exp. Biol. Med. 181:173–177, 1986.PubMedGoogle Scholar
  43. 43.
    Schenck, D.B., Johnson, L.K., Schwartz, K., Sista, H., Scarborough, R.M. and Lewicki, J.A. Biochem. Biophys. Res. Comm. 127:433–442, 1985.CrossRefGoogle Scholar
  44. 44.
    Schenck, D.B., Phelps, N.N., Porter, J.G., Scarborough, R.M., McEnroe, G.A. and Lewicki, J.A. J. Biol. Chem. 260:14887–14890, 1985.Google Scholar
  45. 45.
    Schiffrin, E.L., Chrétien, L., Thibault, G., St-Louis, J., Cantin, M. and Genest, J. Circ. Res. 56:801–807, 1985.PubMedGoogle Scholar
  46. 46.
    Schiffrin, E.L., Poissant, L., Cantin, M. and Thibault, G. Life Sci. (in press).Google Scholar
  47. 47.
    Vandlen, R.L., Arcuri, K.A. and Napier, M.A. J. Biol. Chem. 260: 10889–10892, 1985.PubMedGoogle Scholar
  48. 48.
    Schiffrin, E.L., St-Louis, J., Garcia, R., Thibault, G., Cantin, M. and Genest, J. Hypertension 8 (Suppl. I):I-141–I-145, 1986.Google Scholar
  49. 49.
    Garcia, R., Thibault, G., Hamet, P., Cantin, M. and Genest, J. 10th Scientific Meeting International Society of Hypertension, Interlaken, Switzerland, June 17–21, 1984, abstract 53.Google Scholar
  50. 50.
    Pang, S.C., Hoang, M.C., Tremblay, J., Cantin, M., Garcia, R., Genest, J. and Harriet, P. Clin. Sci. 69:721–726, 1985.PubMedGoogle Scholar
  51. 51.
    Garcia, R., Thibault, G., Gutkowska, J., Horky, K., Hamet, P., Cantin, M. and Genest, J. Proc. Soc. Exp. Biol. Med. 179:396–401, 1985.PubMedGoogle Scholar
  52. 52.
    Garcia, R., Thibault, G., Gutkowska, J., Hamet, P., Cantin, M. and Genest, J. Proc. Soc. Exp. Biol. Med. 178:155–159, 1985.PubMedGoogle Scholar
  53. 53.
    Garcia R., Gutkowska, J., Genest, J., Cantin, M. and Thibault, G. Proc. Soc. Exp. Biol. Med. 179:539–545, 1985.PubMedGoogle Scholar
  54. 54.
    Garcia, R., Thibault, G., Gutkowska, J. and Cantin, M. Hypertension (submitted).Google Scholar
  55. 55.
    Gutkowska, J., Bonnan, R., Roy, D., Bourassa, M., Garcia, R., Thibault, G., Genest, J. and Cantin, M. Biochem. Biophys. Res. Comm. (submitted).Google Scholar
  56. 56.
    Gutkowska, J., Boucher, R and Genest, J. Un. Med. Canad. 106:446–450, 1971.Google Scholar
  57. 57.
    Underwood, B., Williams, G. J. Lab. Clin. Med. 79:848–852, 1972.Google Scholar
  58. 58.
    Noresson, E., Ricksten, S.E. and Thoren, P. Acta Physio. Scand. 107: 9–12, 1979.CrossRefGoogle Scholar
  59. 59.
    Julius, S. and Elser, M. Clin. Sci. 51:2075–2105, 1976.Google Scholar
  60. 60.
    Ricksten, S.E., Yao, T., Ljung, B. and Thoren, P. Acta Physio. Scand. 10:413–418, 1980.CrossRefGoogle Scholar
  61. 61.
    Aguas, A.P., Abecasis, P., Mariano, V. and Nogueira da Costa, J. Hypertension 3:725–729, 1981.PubMedGoogle Scholar
  62. 62.
    Frohlich, E., Tarazi, R.C. and Dustan, H.P. Circulation 44:446–455, 1971.PubMedGoogle Scholar
  63. 63.
    Farmer, B.B., Harris, R.A., Jolly, W.W. and Vail, W.J. Circ. Res. 35; 102–110, 1974.PubMedGoogle Scholar
  64. 64.
    Weiss, L. and Lundgren, Y. Cardiovascular Res. 12:635–638, 1978.CrossRefGoogle Scholar
  65. 65.
    Lang, R.E., Tholken, H., Ganten, D., Luft F.C., Ruskoaho, H. and Unger, T.H. Nature 314:264–266, 1985.PubMedCrossRefGoogle Scholar
  66. 66.
    Lucas, J. and Floyer, M.A. Clin. Sci. Mol. Med. 47:1–11, 1974.PubMedGoogle Scholar
  67. 67.
    London, G.M., Safar, M.E., Safar, A.L. and Simon Ach. J. Hypertens 3: 338–342, 1985.CrossRefGoogle Scholar
  68. 68.
    Olivari, M.T., Fiorentin, C, Polese, A. and Gualli, M.D. Circulation 57:1185–1190, 1978.PubMedGoogle Scholar
  69. 69.
    Safar, M.E., Weiss, Y.A., London, G.M., Frichowiak, R.F. and Milliez, P.L. Clin. Sci. Mol. Med. 47:153–164, 1974.PubMedGoogle Scholar
  70. 70.
    Guyton, A.C., Coleman, T.G., Young, D.B., Lohmeier, T.E. and DeClue, J.W. Ann. Rev. Med. 31:15–27, 1980.PubMedCrossRefGoogle Scholar
  71. 71.
    Bianchi, G. and Bazzato, G. In: The kidney in arterial hypertension. (Bunge Scientific Publishers), Utrecht, pp. 127–136, 1979.Google Scholar
  72. 72.
    Tobian, L., Lange, J., Magraw, S. Circ. Res. 36–37:I-162–I-170, 1975.Google Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • M. Cantin
    • 1
  • R. Garcia
    • 1
  • J. Gutkowska
    • 1
  • G. Thibault
    • 1
  • O. Kuchel
    • 1
  • P. Larochelle
    • 1
  • J. Cusson
    • 1
  • P. Hamet
    • 1
  • E. L. Schiffrin
    • 1
  • J. Genest
    • 1
  1. 1.Multidisciplinary Research Group on HypertensionClinical Research Institute of MontrealMontrealCanada

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