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Triacylglycerol Lipase Activities and Rates of Endogenous Lipolysis in Myocardial Cells from Diabetic Rat Hearts

  • Chapter
Pathophysiology of Heart Disease

Part of the book series: Developments in Cardiovascular Medicine ((DICM,volume 65))

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Abstract

Free fatty acids (FFA) are the preferred substrate for the heart. The sources of FFA for myocardial oxidation are shown in Fig. 1 and include:

  1. (a)

    circulating albumin-bound FFA, derived from the degradation of triacylglycerols (TG) in adipose tissue depots;

  2. (b)

    hydrolysis of the TG component of circulating lipoproteins (for example, very-low density lipoprotein or VLDL-TG) by an enzyme, lipoprotein lipase (LPL), that is located at the capillary endothelium, and that can be released by heparin;

  3. (c)

    hydrolysis of endogenous TG by an intracellular TG lipase (myo-cardial lipolysis).

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Authors and Affiliations

  1. Department of Pharmacology and Therapeutics, Faculty of Medicine, The University of Calgary, Calgary, T2N 4N1, Canada

    D. L. Severson, K. A. Kenno, T. S. Larsen & I. Ramírez

Authors
  1. D. L. Severson
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  2. K. A. Kenno
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  3. T. S. Larsen
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  4. I. Ramírez
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Editor information

Editors and Affiliations

  1. Department of Physiology, Youville Research Institute, St. Boniface General Hospital and University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla , Pawan K. Singal  & Robert E. Beamish ,  & 

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© 1987 Martinus Nijhoff Publishing, Boston

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Severson, D.L., Kenno, K.A., Larsen, T.S., Ramírez, I. (1987). Triacylglycerol Lipase Activities and Rates of Endogenous Lipolysis in Myocardial Cells from Diabetic Rat Hearts. In: Dhalla, N.S., Singal, P.K., Beamish, R.E. (eds) Pathophysiology of Heart Disease. Developments in Cardiovascular Medicine, vol 65. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2051-7_17

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  • DOI: https://doi.org/10.1007/978-1-4613-2051-7_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9219-7

  • Online ISBN: 978-1-4613-2051-7

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