Abstract
The brunt of immune complex deposition in IgA nephropathy is borne by the glomerular mesangium. Glomerular capillary wall deposits of varying extent and severity do occur, however, and these may account for symptoms such as hematuria and morphologic lesions such as acute glomerular necrosis, inflammation, and crescent formation. These seem unlikely, on the other hand, to account for the progressive decline in renal function, development of hypertension, increasing mesangial expansion, and glomerular sclerosis that typify the patient with progressive disease. These features are most likely to be a result of persisting mesangial deposition. Several glomerular diseases leading to chronic renal failure are characterized by similar changes although, in IgA nephropathy, the mesangial pathology clearly is related to deposition of immune material. Others include diabetic glomerulosclerosis, focal glomerulosclerosis, and hereditary glomerulonephritis. It seems, therefore, that alteration in mesangial function as well as structure plays an important role in progressive reduction in glomerular filtration rate in several diseases. In this chapter, their relevance to IgA nephropathy is discussed.
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© 1987 Martinus Nijihoff Publishing, Boston
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Clarkson, A.R. (1987). The Glomerular Mesangium. In: Clarkson, A.R. (eds) IgA Nephropathy. Topics in Renal Medicine, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2039-5_9
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DOI: https://doi.org/10.1007/978-1-4613-2039-5_9
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