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The Pathology of IgA Nephropathy

  • Chapter
IgA Nephropathy

Part of the book series: Topics in Renal Medicine ((TIRM,volume 2))

Abstract

Mesangial IgA nephropathy was first identified in France by Berger in 1968 [1, 2], and has been referred to as Berger’s disease. The lesion is characterized by diffuse mesangial deposition of immunoglobulins, with IgA predominating. There should be no systemic manifestations, and secondary diseases of systemic lupus erythematosus [3], Henoch-Schönlein purpura [4, 5], liver cirrhosis [6–8], and cancer, especially mucin-secreting adenocarcinomas [9, 10] should be excluded, as they are also known to have IgA deposits in the glomerular mesangium. The glomerular immunopathology of IgA nephropathy is identical with that of Henoch-Schönlein purpura, and some authors believe that IgA nephropathy is a forme fruste of Henoch-Schönlein purpura.

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References

  1. Berger J, Hinglais N: Les dépôts intercapillaires d’IgA-IgG. J Urol (Paris) 74:694–695, 1968.

    CAS  Google Scholar 

  2. Berger J: IgA glomerular deposits in renal disease. Transplant Proc 1:934–944, 1969.

    Google Scholar 

  3. Sinniah R, Feng PH: Lupus nephritis: correlation between light, electron microscopic and immunofluorescent findings and renal function. Clin Nephrol 6:340–351, 1976.

    PubMed  CAS  Google Scholar 

  4. Clarkson AR, Seymour AE, Thompson AJ, Haynes WDG, Chan YL, Jackson B: IgA nephropathy: a syndrome of uniform morphology, diverse clinical features, and uncertain prognosis. Clin Nephrol 8:459–471, 1977.

    PubMed  CAS  Google Scholar 

  5. Sinniah R, Feng PH, Chen BTM: Henoch-Schönlein syndrome: a clinical and morphological study of renal biopsies. Clin Nephrol 9:219–228, 1978.

    PubMed  CAS  Google Scholar 

  6. Callard P, Feldmann G, Prandi P, Belair MF, Maudet C, Weiss Y, Druet P, Benhamou JP, Bariety J: Immune complex type glomerulonephritis in cirrhosis of the liver. Am J Pathol 80:329–337, 1975.

    PubMed  CAS  Google Scholar 

  7. Berger J, Yaneva H, Nabarra B: Glomerular changes in patients with cirrhosis of the liver. In: Hamburger J, Crosnier J, Maxwell H (eds) Advances in nephrology. Chicago: Year Book Medical, 1978, pp. 3–14.

    Google Scholar 

  8. Sinniah R: Heterogeneous IgA glomerulonephropathy in liver cirrhosis. Histopathology 8:947–962, 1984.

    Article  PubMed  CAS  Google Scholar 

  9. Sinniah R: Mucin secreting cancer with mesangial IgA deposits. Pathology 14:303–308, 1982.

    Article  PubMed  CAS  Google Scholar 

  10. Mustonen J, Pasternack A, Helin H: IgA mesangial nephropathy in neoplastic diseases. In: D’Amico G, Minetti L, Ponticelli C (eds) IgA mesangial nephropathy. Basel: Karger, 1984, pp 283–291.

    Google Scholar 

  11. Morel-Maroger L, Leathern A, Richet G: Glomerular abnormalities in non-systemic diseases: relationship between findings by light microscopy and immunofluorescence in 433 renal biopsy specimens. Am J Med 53:170–184, 1972.

    Article  PubMed  CAS  Google Scholar 

  12. Droz D: Natural history of primary glomerulonephritis with mesangial deposits of IgA. Contrib Nephrol 2:150–157, 1976.

    Google Scholar 

  13. Di Belgiojoso GB, Tarantino A, Civati G, Limido D, Minetti L: Glomerulonefrite A depositi intercapillari di IgA-IgG: studio clinico E. morfologico di 63 casi. Rincera Clin Lab 3:30–62, 1973.

    Google Scholar 

  14. Colasanti G, Banfi G, Di Belgiojoso B, Bertoli S, Fogazzi G, Rangni A, Ponticelli C, Minetti L, D’Amico G: Idiopathic IgA mesangial nephropathy: clinical features. Contrib Nephrol 18:147–156, 1984.

    Google Scholar 

  15. D’Amico G: Natural history and treatment of idiopathic IgA nephropathy. In: Robinson RR, et al. [eds] Nephrology, vol 1: proceedings of the 9th international congress of nephrology. New York: Springer-Verlag, 1984, pp 686–701.

    Google Scholar 

  16. Shirai T, Tomino Y, Sato M, Yoshiki T, Itoh T: IgA nephropathy: clinicopathology and immunopathology. Contrib Nephrol 9:88–100, 1978.

    PubMed  CAS  Google Scholar 

  17. Sakai O, Kitajima T, Kawamma K, Ueda Y: Clinicopathological studies on IgA glomerulonephritis: In: Yoshitoshi Y, Ueda Y (eds) Glomerulonephritis: proceedings of the international symposium on glomerulonephritis, Tokyo 1977. Tokyo: University of Tokyo Press, 1979, pp 167–180.

    Google Scholar 

  18. Sinniah R, Pwee HS, Lim CH: Renal glomerular lesions in patients with asymptomatic microscopic haematuria-proteinuria discovered on a routine medical examination. Ann Acad Med [suppl] 4:11–16, 1975.

    Google Scholar 

  19. Sinniah R, Javier AR, Ku G: The pathology of mesangial IgA nephritis with clinical correlation. Histopathology 5:469–490, 1981.

    Article  PubMed  CAS  Google Scholar 

  20. Levy M, Beaufils H, Gubler MC, Habib R: Idiopathic recurrent macroscopic haematuria and mesangial IgA-IgG deposits in children (Berger’s disease). Clin Nephrol 1:63–69, 1973.

    Google Scholar 

  21. Hyman LR, Wagnild JP, Beirne GJ, Burkholder PM: Immunoglobulin-A distribution in glomerular disease: analysis of immunofluorescence localization and pathogenetic significance. Kidney Int 3:397–408, 1973.

    Article  PubMed  CAS  Google Scholar 

  22. McCoy RC, Abramowsky CR, Tisher CC: IgA nephropathy. Am J Pathol 76:123–144, 1974.

    PubMed  CAS  Google Scholar 

  23. Sissons JGP, Woodrow DF, Curtis JR, Evans DJ, Gower PE, Sloper JC, Peters DK: Isolated glomerulonephritis with mesangial IgA deposits. Br Med J 3:611–614, 1975.

    Article  PubMed  CAS  Google Scholar 

  24. Sinniah R, Pwee HS, Lim CH: Glomerular lesions in asymptomatic microscopic haematuria discovered on routine medical examination. Clin Nephrol 5:216–228, 1976.

    PubMed  CAS  Google Scholar 

  25. Bariety J, Druet PH: Résultats de 1’immunohistochimie de 589 biopsies rénales (transplantés exclus). Ann Med Int 122:63–69, 1971.

    CAS  Google Scholar 

  26. Woodroffe AJ, Thompson NM, Meadows R, Lawrence JR: IgA-associated glomerulonephritis. Aust NZ J Med 5:97–100, 1975.

    Article  CAS  Google Scholar 

  27. Alexander F, Barabas AZ, Jack RGJ: IgA nephropathy. Hum Pathol 8:173–185, 1977.

    Article  PubMed  CAS  Google Scholar 

  28. D’Amico G: Idiopathic mesangial IgA nephropathy. In: Bertani T, Remuzzi G (eds) Glomerular Injury 300 years after Morgagni. Milan: Wichtig Editore, 1983, pp 205–228.

    Google Scholar 

  29. Druet P, Bariety J, Bernard D, Lagrue G: Les glomérulopathies primitives à dépóts mésangiaux d’IgA et d’IgG: étude clinique et morphologique de 52 cas. Presse Med 78:583–587, 1970.

    Google Scholar 

  30. Davies DR, Tighe JR, Jones NF, Brown GW: Recurrent haematuria and mesangial IgA deposition. J Clin Pathol 26:672–677, 1973.

    Article  PubMed  CAS  Google Scholar 

  31. Covarsi A, Flores R, Barcelo P, Santaularia JM, Bailarín J, Del Rio G: Glomerulonephritis por depositos mesangiales de IgA (enfermedad de Berger) Parámetros evolutivos. Nefrologia 1:1–12, 1981.

    Google Scholar 

  32. Mandreoli M, Pasquali S, Donini V, Casanova S, Cagnoli L: Correlazioni anotomo-cliniche in corso di malattia di Berger. Nefrol Dial 1:9–16, 1981.

    Google Scholar 

  33. Vangelista A, Frasca GM, Mardini S, Bonomini V: Idiopathic IgA mesangial nephropathy: immunohistological features. Contrib Nephrol 40:167–173, 1984.

    PubMed  CAS  Google Scholar 

  34. Waldherr R, Rambausek M, Rauterberg W, Andrassy K, Ritz E: Immunohistochemical features of mesangial IgA glomerulonephritis. Contrib Nephrol 40:99–106, 1984.

    PubMed  CAS  Google Scholar 

  35. Zimmerman SW, Burkholder PM: Immunoglobulin A nephropathy. Arch Intern Med 135:1217–1223, 1975.

    Article  PubMed  CAS  Google Scholar 

  36. Katz A, Underdown BJ, Minta JO, Lepow IH: Glomerulonephritis with mesangial deposits of IgA unassociated with systemic disease. CMA J 114:209–216, 1976.

    CAS  Google Scholar 

  37. Burkholder PM, Zimmermann SW, Moorthy AV: A clinicopathologic study of the natural history of mesangial IgA nephropathy. In: Yoshitoshi Y, Ueda Y (eds) Glomerulonephritis: progression and regression. Baltimore: University Park Press, 1979, pp 143–166.

    Google Scholar 

  38. Woodroffe AJ, Gormly AA, McKenzie PE, Wootton AM, Thompson AJ, Seymour AE, Clarkson AR: Immunologic studies in IgA nephropathy. Kidney Int 18:366–372, 1980.

    Article  PubMed  CAS  Google Scholar 

  39. Ueda Y, Sakai O, Yamagata M, Kitajima T, Kawamura K: IgA glomerulonephritis in Japan. Contrib Nephrol 4:36–47, 1977.

    Google Scholar 

  40. Yokoska H, Nagase M, Maeda T, Koide K: Mesangial IgA glomerulonephritis: clinicopathological study of 85 cases. Contrib Nephrol 9:101–110, 1978.

    PubMed  CAS  Google Scholar 

  41. Nakamoto Y, Asano Y, Dohi K, Fujioka M, Iida H, Kida H, Kibe Y, Hattori N, Takeuchi J: Primary IgA glomerulonephritis and Schönlein-Henoch purpura nephritis: clinicopathological and immunohistological characteristics. Q J Med 47:495–516, 1978.

    PubMed  CAS  Google Scholar 

  42. Ng WL, Chan CW, Yeung CK, Hua SP: The pathology of primary IgA glomerulonephritis: a renal biopsy study. Pathology 13:137–143, 1981.

    Article  PubMed  CAS  Google Scholar 

  43. Sinniah R, Ku G: Clinicopathologic correlations in IgA nephropathy. In: Robinson RR, et al. (ed) Nephrology, vol 1, New York: Springer-Verlag, 1984, pp 665–685.

    Google Scholar 

  44. Juncos L, Schlein E, Teague P, Waldman R, Cade R: Immunoglobulin A glomerulonephritis: a clinicopathologic study. Lab Invest 32:140–148, 1975.

    PubMed  Google Scholar 

  45. Götze O, Müller-Eberhard HJ: The C3-activator system an alternate pathway of complement activation. J Exp Med 134:90–108, 1971.

    PubMed  Google Scholar 

  46. Evans DJ, Williams GD, Peters DK, Sissons JGP, Boulton-Jones JM, Ogg CS, Cameron JS, Hoffbrand B: Glomerular deposition of properdin in Henoch-Schönlein syndrome and idiopathic focal nephritis. Br Med J 3:326–328, 1973.

    Article  PubMed  CAS  Google Scholar 

  47. Southwest Pediatric Nephrology Study Group: A multicentric study of IgA nephropathy in children. Kidney Int 22:643–652, 1982.

    Article  Google Scholar 

  48. Hara M, Endo Y, Nihei H, Hara S, Fukushima O, Mimura N: IgA glomerulonephritis with subendothelial deposits. Virchows Arch [Pathol Anat] 386:249–263, 1980.

    Article  CAS  Google Scholar 

  49. Lowance DC, Mullins JD, McPhaul JJ: Immunoglobulin A (IgA) associated glomerulonephritis. Kidney Int 3:167–176, 1973.

    Article  PubMed  CAS  Google Scholar 

  50. Dobrin RS, Knudson FE, Michael AF: The secretory immune system and renal disease. Clin Exp Immunol 21:318–328, 1975.

    PubMed  CAS  Google Scholar 

  51. Tsuchida H, Shishido H, Koyama A, Hirose K, Narita M, Tojo S, Ito H, Iwama H, Sanada T, Mitsuhashi S, Okada M: Chance hematuria and/or proteinuria: immunopathologic studies on Japanese patients with special reference to mesangial IgA nephropathy [abstr 359]. In: 4th international congress of nephrology, Florence, 1975.

    Google Scholar 

  52. Tourville DR, Adler RH, Bienenstock J, Tornasi TB: The human secretory immunoglobulin system: immunohistological localization of gamma A, secretory “piece” and lactoferrin in normal human tissues. J Exp Med 129:411–429, 1969.

    Article  PubMed  CAS  Google Scholar 

  53. Lomax-Smith JD, Zabrowarny LA, Howarth GS, Seymour AE, Woodroffe AJ: The immunochemical characterization of mesangial IgA deposits. Am J Pathol 113:359–364, 1983.

    PubMed  CAS  Google Scholar 

  54. André C, Berthoux FC, André F, Gillon J, Genin C, Sabatier J-C: Prevalence of IgA2 deposits in IgA nephropathies: a clue to their pathogenesis. N Engl J Med 303:1343–1346, 1980.

    Article  PubMed  Google Scholar 

  55. Bene MC, Faure G, Levy M, Duheille J: Identification de la sous-classe IgAl et/ou IgA2 des dépôts mésangiaux d’IgA. Nouv Presse Med 11:2639–2640, 1982.

    Google Scholar 

  56. Conley ME, Cooper MD, Michael AF: Selective deposition of immunoglobulin Al in immunoglobulin A nephropathy, anaphylactoid purpura nephritis, and systemic lupus erythematosus. J Clin Invest 66:1432–1436, 1980.

    Article  PubMed  CAS  Google Scholar 

  57. Tornino Y, Endoh M, Nomoto Y, Sakai H: Immunoglobulin Al in IgA Nephropathy. N Engl J Med 305:1159–1160, 1981.

    Article  Google Scholar 

  58. Tornino Y, Sakai M, Miura M, Endoh M, Nomoto Y: Detection of polymeric IgA in glomeruli from patients with IgA nephropathy. Clin Exp Immunol 49:419–425, 1982.

    Google Scholar 

  59. Hall RP, Stachura I, Cason J, Whiteside TL, Lawley TL: IgA-containing circulating immune complexes in patients with IgA nephropathy. Am J Med 74:56–63, 1983.

    Article  PubMed  CAS  Google Scholar 

  60. Valentijn RM, Radi J, Haaiman JJ, Daha MR, Van Es LA: Circulating macromolecular IgA-1 and mesangial secretory component-binding IgA-1 in primary IgA nephropathy [abstr] Kidney Int 24:408, 1983.

    Google Scholar 

  61. Katz A, Newkirk MH, Klein MH: Circulating and mesangial IgA in IgA nephropathy. In: D’Amico G, Minetti L, Ponticelli C (eds) IgA mesangial nephropathy. Contrib Nephrol 40:74–79, 1984.

    Google Scholar 

  62. Delacroix DL, Liroux E, Vaerman JP: High proportion of polymeric IgA in young infants’ sera and independence between IgA-size and IgA subclass distributions. J Clin Immunol 3:53–58, 1983.

    Article  Google Scholar 

  63. Crago SS, Kutteh WH, Prince SJ, Radi J, Haajman JJ, Mestecky J: Distribution of IgAl and IgA2 subclasses in human tissue: correlation with the presence of J-chain. Ann NY Acad Sci 409:803–805, 1983.

    Article  Google Scholar 

  64. Conley ME, Koopman WJ: Serum IgAl and IgA2 in normal adults and patients with systemic lupus erythematosus and hepatic disease. Clin Immunol Immunopathol 26:390–397, 1983.

    Article  PubMed  CAS  Google Scholar 

  65. Murakami T, Furuse A, Hattori S, Kobayashi K, Matsuda I: Glomerular IgAl and IgA2 deposits in IgA nephropathies. Nephron 35:120–123, 1983.

    Article  PubMed  CAS  Google Scholar 

  66. Bene MC, Faure G, Duheille J: IgA-nephropathy: characterization of the polymeric nature of mesangial deposits by in vitro binding of free secretory component. Clin Exp Immunol 47:527–534, 1982.

    PubMed  CAS  Google Scholar 

  67. Komatsu N, Nagura H, Watanabe K, Nomoto Y, Kobayashi K: Mesangial deposition of J chain-linked polymeric IgA in IgA Nephropathy. Nephron 33:61–64, 1983.

    CAS  Google Scholar 

  68. Egido J, Sancho J, Mampaso F, Lopez-Trascasa M, Sánchez-Crespo M, Blasco R, Hernando L: A possible common pathogenesis of the mesangial IgA glomerulonephritis in patients with Berger’s disease and Schönlein-Henoch syndrome. Proc Eur Dial Transplant Assoc 17:660–666, 1980.

    PubMed  CAS  Google Scholar 

  69. De Werra P, Morel-Maroger L, Leroux-Robert C, Richet G: Glomérulites à dépots d’IgA diffus dans le mésangium: étude de 96 cas chez l’adulte. Schweiz Med Wochenschr 103:761–768 and 797–803, 1973.

    Google Scholar 

  70. Baart de la Faille-Kuyper EH, Kater L, Kuigten RH, Kooiker CJ, Wagenaar SS, Van der Zuuwen P, Dorhout Mees EJ: Occurrence of vascular IgA deposits in clinical normal skin of patients with renal disease. Kidney Int 9:424–429, 1976.

    Article  PubMed  CAS  Google Scholar 

  71. Ku G, Sinniah R, Seah PP, Loke GKF, Lau YK, Chan HL, Tay L, Khoo OT: Simultaneous analysis of renal biopsy, immunochemistry and immunofluorescent studies of clinically normal skin in glomerulonephritis. J Med Assoc Thai [Suppl 1] 61:3–9, 1978.

    Google Scholar 

  72. Berger J, Yaneva H, Nabarra B, Barbanel C: Recurrence of mesangial deposition of IgA after renal transplantation. Kidney Int 7:232–241, 1975.

    Article  PubMed  CAS  Google Scholar 

  73. López-Trascasa M, Egido J, Sancho J, Hernando L: IgA glomerulonephritis (Berger’s disease): evidence of higher serum levels of polymeric IgA. Clin Exp Immunol 42:247–254, 1980.

    Google Scholar 

  74. Rifai A, Small PA Jr, Teague PO, Ayoub EM: Experimental IgA nephropathy. J Exp Med 150:1161–1173, 1979.

    Article  PubMed  CAS  Google Scholar 

  75. Kurt Lee SM, Rao VM, Franklin WA, Schiffer MS, Aronson AJ, Spargo BH, Katz AI: IgA nephropathy: morphologic predictors of progressive renal disease. Hum Pathol 13:314–322, 1982.

    Article  PubMed  CAS  Google Scholar 

  76. Hogg RJ, Silva FG: IgA nephropathy: natural history and prognostic indices in children. Contrib Nephrol 40:214–221, 1984.

    PubMed  CAS  Google Scholar 

  77. Mihatsch MJ, Imbasciati E, Fogazzi G, Giani M, Chio L, Gaboardi F: Ultrastructural lesions of Henoch-Schönlein syndrome and IgA nephropathy: similarities and differences. Contrib Nephrol 40:255–263, 1984.

    PubMed  CAS  Google Scholar 

  78. Kupor LR, Mullins JD, McPhaul JJ Jr: Immunopathologic findings in idiopathic renal hematuria. Arch Intern Med 135:1204–1211, 1975.

    Article  PubMed  CAS  Google Scholar 

  79. Finlayson G, Alexander R, Juncos L, Schiein E, Teague P, Waldman R, Cade R: Immunoglobulin A glomerulonephritis: a clinicopathologic study. Lab Invest 32:140–148, 1975.

    PubMed  CAS  Google Scholar 

  80. Sinniah R: IgA mesangial nephropathy: Berger’s disease, [editorial review]. Am J Nephrol 5:73–83, 1985.

    Article  PubMed  CAS  Google Scholar 

  81. Churg J, in collaboration with LH Sobin and pathologists and nephrologists in 14 countries: Renal disease: classification and atlas of glomerular diseases. Tokyo: Igaku-Shoin, 1982.

    Google Scholar 

  82. Droz D, Kramar A, Nawar T, Noel LH: Primary IgA nephropathy: prognostic factors. Contrib Nephrol 40:202–207, 1984.

    PubMed  CAS  Google Scholar 

  83. D’Amico G, Di Belgiojoso B, Imbasciati E, Fogazzi G, Radaelli L, Ferrario F, Fellin G, Ponticelli C, Minetti L: Idiopathic IgA mesangial nephropathy: natural history. Contrib Nephrol 40:208–213, 1984.

    PubMed  Google Scholar 

  84. Clarkson AR, Seymour AE, Woodroffe AJ: Primary renal hematuria: IgA nephropathy. In: Massry SG, Glassock RJ (eds) Text book of nephrology, vol 1. Baltimore: Williams and Wilkins, 1983, pp 6.56–6.61.

    Google Scholar 

  85. Feiner HD, Galvin S, Neelakantappa K, Baldwin D, Gallo GR: Vessel sclerosis and progression in IgA nephropathy. Contrib Nephrol 40:222–227, 1984.

    PubMed  CAS  Google Scholar 

  86. Navas-Palacios JJ, Gutierrez-Millet LV, Usera-Sárraga G, Garzón-Martin A: IgA nephropathy: an ultrastructural study. Ultrastruct Pathol 2:151–161, 1981.

    Article  PubMed  CAS  Google Scholar 

  87. Okada M, Tsuchida H, Yamamoto S: Familial mesangial IgA Nephropathy. In: Yoshitoshi Y, Ueda Y (eds) Glomerulonephritis progression and regression. Baltimore: University Park Press, 1978, pp 201–223.

    Google Scholar 

  88. Ng WL, Chan KW, Yeung CK, Kwan S: Peripheral glomerular capillary wall lesions in IgA nephropathy and their implications. Pathology 16:324–330, 1984.

    Article  PubMed  CAS  Google Scholar 

  89. Singer DB, Hill LL, Rosenberg HS, Marshall J, Swenson R: Recurrent hematuria in childhood. N Engl J Med 279:7–12, 1968.

    Article  PubMed  CAS  Google Scholar 

  90. Sinniah R, Churg J: Effect of IgA deposits on the glomerular mesangium in Berger’s disease. Ultrastruct Pathol 4:9–22, 1983.

    Article  PubMed  CAS  Google Scholar 

  91. Vernier RL, Resnick JS, Mauer SM: Recurrent hematuria and focal glomerulonephritis. Kidney Int 7:224–231, 1975.

    Article  PubMed  CAS  Google Scholar 

  92. Shigematsu H, Kobayashi Y, Tateno S, Hiki Y, Kuwao S: Ultrastructural glomerular loop abnormalities in IgA nephropathy. Nephron 30:1–7, 1982.

    Article  PubMed  CAS  Google Scholar 

  93. Sinclair RA, Antonovych TT, Mostofi FK: Renal proliferative arteriopathies and associated glomerular changes: a light and electron microscopic study. Hum Pathol 7:565–588, 1976.

    Article  PubMed  CAS  Google Scholar 

  94. Valentijn RM, Kauffmann RH, Brutel de La Rivière G, Daha MR, Van Es LA: Presence of circulating macromolecular IgA in patients with hematuria due to primary IgA nephropathy. Am J Med 74:375–381, 1983.

    Article  PubMed  CAS  Google Scholar 

  95. Egido J, Sancho J, Rivera F, Hernando L: The role of IgA and IgG immune complexes in IgA nephropathy. Nephron 36:59–66, 1984.

    Article  Google Scholar 

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  1. Raja Sinniah
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Anthony R. Clarkson

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Sinniah, R. (1987). The Pathology of IgA Nephropathy. In: Clarkson, A.R. (eds) IgA Nephropathy. Topics in Renal Medicine, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2039-5_6

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