Abstract
The recognition of Berger’s disease is still relatively recent and awareness of its high prevalence and true functional importance is even more so. Therefore, one of our first obligations should be to educate the profession with respect to the diagnostic importance of IgA nephropathy as a frequent cause of hematuria, proteinuria, hypertension, and renal failure. In doing so, we should stress the significance of “synpharyngitic” hematuria and of the presence of “glomerular type” red blood cells in the urine and referral for renal biopsy should be advocated as the definitive investigation in such patients. Without such promotion, the condition will continue to be underdiagnosed and its true prevalence grossly understated. In turn, we need to carry out formal epidemiologic and life-table analytic studies of IgA nephropathy, as exemplified by Sinniah et al. in Singapore [1, 2] and D’Amico in Milan [3].
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References
Sinniah R, Pwee HS, Lim CH: Glomerular lesions in asymptomatic microscopic haematuria discovered on routine medical examination. Clin Nephrol 5:216–228, 1976.
Sinniah R, Lim CH, Pwee HS: Glomerular lesions in patients with asymptomatic persistent and orthostatic proteinuria discovered on routine medical examination. Clin Nephrol 7:1–14, 1977.
D’Amico G: Natural history and treatment of idiopathic IgA nephropathy. In: Robinson RR (ed) Proceedings of the 9th international congress on nephrology, vol 1. New York: Springer-Verlag, 1984, pp 686–701.
Seventh Report of the Australian and New Zealand Dialysis and Transplant Registry, July 1984.
1st international Milano meeting of nephrology on IgA mesangial nephropathy. Contrib Nephrol 40: – , 1983.
Symposium on IgA nephropathy, Los Angeles. In: Robinson RR (ed) International congress on nephrology, vol 1. New York: Springer-Verlag, 1984, pp 645–701.
Woodroffe AJ, Wilson CB: An evaluation of elution techniques in the study of immune complex glomerulonephritis. J Immunol 118:1788–1794, 1977.
Tomino Y, Endoh M, Nomoto Y, Sakai H: Specificity of eluted antibodies from renal tissues of patients with IgA nephropathy. Am J Kidney Dis 1:276–280, 1982.
Tomino Y, Sakai H, Endoh M, Suga T, Miura M, Kaneshige H, Nomoto Y: Cross-reactivity of IgA antibodies between renal mesangial areas and nuclei of tonsillar cells in patients with IgA nephropathy. Clin Exp Immunol 51:605–610, 1983.
Delacroix DL, Elkon KB, Geubel AP, Hodgson HF, Dive C, Vaerman JP: Changes in size, subclass, and metabolic properties of serum immunoglobulin A in liver diseases and in other diseases with high serum immunoglobulin A. J Clin Invest 71:358:367, 1983.
Westberg NG, Baklien K, Schmekel B, Gillberg R, Brandtzaeg P: Quantitation of immunoglobulin-producing cells in small intestinal mucosa of patients with IgA nephropathy. Clin Immunol Immunopathol 26:442–445, 1983.
Bene MC, Faure G, Hurault de Ligny B, Kessler M, Duheille J: Quantitative immunohistomorphometry of the tonsillar plasma cells evidences an inversion of the immunoglobulin A versus immunoglobulin G secreting cell balance. J Clin Invest 71:1342–1347, 1983.
Egido J, Blasco R, Lozano L, Sancho J: Immunological abnormalities in tonsils of patients with IgA nephropathy: inversion in the percentage of IgA verus IgG-bearing lymphocytes and increased polymeric IgA synthesis. Clin Exp Immunol 57:101–106, 1984.
Tomino Y, Endoh M, Kaneshige H, Nomoto Y, Sakai H: Increase of IgA in pharyngeal washings from patients with IgA nephropathy. Am J Med Sci 286:15–21, 1983.
Emancipator SN, Gallo GR, Lamm ME: Experimental IgA nephropathy induced by oral immunization. J Exp Med 157:572–582, 1983.
Disney APS: Australian and New Zealand Dialysis and Transplant Registry, 1985.
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© 1987 Martinus Nijhoff Publishing, Boston
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Woodroffe, A.J. (1987). The Future: An Australian Perspective. In: Clarkson, A.R. (eds) IgA Nephropathy. Topics in Renal Medicine, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2039-5_17
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DOI: https://doi.org/10.1007/978-1-4613-2039-5_17
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