Skip to main content
SpringerLink
Log in

Summary of the Pathogenesis of IgA Nephropathy

  • Chapter
IgA Nephropathy

Part of the book series: Topics in Renal Medicine ((TIRM,volume 2))

Abstract

As in so many conditions, the causes of IgA nephropathy and its close relative, Henoch-Schönlein purpura (HSP), remain obscure despite considerable efforts in human and animal experimentation. However, such efforts over the past ten years have taught us something about the mechanisms involved in mesangial IgA nephritis and this chapter reviews this knowledge, paying special tribute to those involved and emphasizing areas that may prove ultimately to be of diagnostic, prognostic, or therapeutic value to patients with IgA nephropathy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Woodroffe AJ, Clarkson AR, Seymour AE, Lomax-Smith JD: Mesangial IgA nephritis. Springer Semin Immunopathol 5:321–332, 1982.

    Article  PubMed  CAS  Google Scholar 

  2. Miyazaki R, Kuroda M, Akiyama T, Otani I, Tofuku Y, Takeda R: Glomerular deposition and serum levels of complement control proteins in patients with IgA nephropathy. Clin Nephrol 21:335–340, 1984.

    PubMed  CAS  Google Scholar 

  3. Andre C, Berthoux FC, Andre F, Gillon J, Genin C, Sabatier J-C: Prevalence of IgA2 deposits in IgA nephropathies. N Engl J Med 303:1343–1346, 1980.

    Article  PubMed  CAS  Google Scholar 

  4. Conley ME, Cooper MD, Michael AF: Selective deposition of immunoglobulin A1 in immunoglobulin A nephropathy, anaphylactoid purpura nephritis, and systemic lupus erythematosus. J Clin Invest 66:1432–1436, 1980.

    Article  PubMed  CAS  Google Scholar 

  5. Tomino Y, Endoh M, Nomoto Y, Sakai H: Immunoglobulin A1 in IgA nephropathy. N Engl J Med 305:1159–1160, 1981.

    Article  PubMed  CAS  Google Scholar 

  6. Lomax-Smith JD, Zabrowarny LA, Howarth GS, Seymour AE, Woodroffe AJ: The immunochemical characterization of mesangial IgA deposits. Am J Pathol 113:359–364, 1983.

    PubMed  CAS  Google Scholar 

  7. Katz A, Nenkirk MM, Klein MH: Circulating and mesangial IgA in IgA nephropathy. Contrib Nephrol 40:74–79, 1984.

    PubMed  CAS  Google Scholar 

  8. Tomino Y, Sakai H, Miura M, Endoh M, Nomoto Y: Detection of polymeric I in glomeruli from patients with IgA nephropathy. Clin Exp Immunol 49:419–425, 1982.

    PubMed  CAS  Google Scholar 

  9. Egido J, Sancho J, Blasco R, Lozano L, Hernando L: Immunologic aspects of IgA nephropathy in humans. In: Robinson RR (ed) Proceedings of the 9th international congress on nephrology, vol 1. New York: Springer-Verlag, 1984, pp 652–664.

    Google Scholar 

  10. Monteiro RC, Habwachs-Mecarelli L, Berger J, Lesavre P: Characteristics of eluted IgA in priamry IgA nephropathy. Contrib Nephrol 40:107–111, 1984.

    PubMed  CAS  Google Scholar 

  11. Egido J, Sancho J, Mampaso F, Lopez-Trascasa M, Sanchez-Crespo M, Blasco R, Hernando L: A possible common pathogenesis of the the mesangial IgA glomerulonephritis in patients with Berger’s disease and Schönlein-Henoch syndrome. Proc Eur Dial Transplant Assoc 17:660–666, 1980.

    PubMed  CAS  Google Scholar 

  12. Valentijn RM, Radi J, Haayman JJ, Vermeer BJ, Weening JJ, Kauffmann RH, Daha MR, van Es LA: Macromolecular IgA in the circulation and mesangial deposits in patients with primary IgA nephropathy. Contrib Nephrol 40:87–92, 1984.

    PubMed  CAS  Google Scholar 

  13. Droz D, Noel LH, Barbanel C, Leibowitch J: Glomérulonéphrite à dépôts intercapillaires d’I lors d’une gammapathie monoclonale benigne. Nouv Presse Med 10:3652–3653, 1981.

    PubMed  CAS  Google Scholar 

  14. Lowance DC, Mullins JD, Mhaul JJ: Immunoglobulin A (IgA) associated glomerulonephritis. Kideny Int 3:167–176, 1973.

    Article  CAS  Google Scholar 

  15. Tomino Y, Endoh M, Nomoto Y, Sakai H: Specificity of eluted antibody from renal tissue of patients with IgA nephropathy. Am J Kidney Dis 1:276–280, 1982.

    PubMed  CAS  Google Scholar 

  16. Tomino Y, Sakai H, Endoh M, Suga T, Miura M, Kaneshige H, Nomoto Y: Cross-reactivity of IgA antibodies between renal mesangial areas and nuclei of tonsillar cells in patients with IgA nephropathy. Clin Exp Immunol 51:605–610, 1983.

    PubMed  CAS  Google Scholar 

  17. Emancipator SN, Gallo GR, Lamm ME: Experimental IgA nephropathy induced by oral immunization. J Exp Med 157:572–582, 1983.

    Article  PubMed  CAS  Google Scholar 

  18. Sinniah R, Ku G: Clinicopathologic correlations in IgA nephropathy. In: Robinson RR (ed) Proceedings of the 9th international congress on nephrology, vol 1. New York: Springer-Verlag, 1984, pp 665–685.

    Google Scholar 

  19. Pfaffenbach G, Lamm ME, Gigli I: Activation of the guinea pig alternative complement pathway by mouse IgA immune complexes. J Exp Med 155:231–247, 1982.

    Article  PubMed  CAS  Google Scholar 

  20. Scharschmidt LA, Dunn MJ: Prostaglandin synthesis by rat glomerular mesangial cells in culture: effect of angiotensin II and arginine vasopressin. J Clin Invest 71:1756–1764, 1983.

    Article  PubMed  CAS  Google Scholar 

  21. Hooke DH, Hancock WW, Gee DC, Kraft N, Atkins RC: Monoclonal antibody analysis of glomerular hypercellularity in human glomerulonephritis. Clin Nephrol 22:163–168, 1984.

    PubMed  CAS  Google Scholar 

  22. Schreiner GF, Cotran RS: Localization of an la-bearing glomerular cell in the mesangium. J Cell Biol 94:483–488, 1982.

    Article  PubMed  CAS  Google Scholar 

  23. Couser WG: Mesangial IgA nephropathies: steady progress. West Med 140:89–91, 1984.

    CAS  Google Scholar 

  24. Sinniah R, Chur: Effect of IgA deposits on the glomerular mesangium in Berger’s disease. Ultrastruct Pathol 4:9–22, 1983.

    Article  PubMed  CAS  Google Scholar 

  25. Clarkson AR, Seymour AE, Thompson AJ, Haynes WDG, Chan Y-L, Jackson B: IgA nephropathy: a syndrome of uniform morphology diverse clinical features and uncertain prognosis. Clin Nephrol 8:457–471, 1977.

    Google Scholar 

  26. Coppo R, Basolo B, Martina G, Rollino C, De Marchi M, Giacchino F, Mazzucco G, Messina M, Piccoli G: Circulating immune complexes containing IgA, IgG and IgM in patients with primary IgA nephropathy and with Henoch-Schoenlein nephritis: correlation with clinical and histologic signs of activity. Clin Nephrol 18:230–239, 1982.

    PubMed  CAS  Google Scholar 

  27. Lesavre P, Digeon M, Bach JF: Analysis of circulating IgA and detection of immune complexes in primary IgA nephropathy. Clin Exp Immunol 48:61–69, 1982.

    PubMed  CAS  Google Scholar 

  28. Doi T, Kanatsu K, Sekita K, Yoshida H, Nagai H, Hamashima Y: Detection of IgA class circulating immune complexes bound to anti-C3d antibody in patients with IgA nephropathy. J Immunol Methods 69:95–104, 1984.

    Article  PubMed  CAS  Google Scholar 

  29. Egido J, Sancho J, Hernando P, Gonzalez J, Hernando L: Presence of specific IgA immune complexes in IgA nephropathy. Contrib Nephrol 40:80–86, 1984.

    PubMed  CAS  Google Scholar 

  30. Rifai A, Small PA, Teague PO, Ayoub EM: Experimental IgA nephropathy. J Exp Med 150:1161–1173, 1979.

    Article  PubMed  CAS  Google Scholar 

  31. Sancho J, Egido J, Rivera F, Hernando L: Immune complexes in IgA nephropathy: presence of antibodies against diet antigens and delayed clearance of specific polymeric IgA immune complexes. Clin Exp Immunol 54:194–202, 1983.

    PubMed  CAS  Google Scholar 

  32. Tomino Y, Sakai H, Suga T, Miura M, Kaneshige H, Endoh, M, Nomoto Y: Impaired solubilization of glomerular immune deposits by sera from patients with IgA nephropathy. Am J Kidney Dis 3:48–54, 1983.

    PubMed  CAS  Google Scholar 

  33. Tomino Y, Sakai H, Miura M, Suga T, Endoh M, Nomoto Y: Effect of danazol in solubilization of immune deposits in patients with I nephropathy. Am J Kidney Dis 4:135–140, 1984.

    PubMed  CAS  Google Scholar 

  34. Woodroffe AJ, Gormly AA, Menzie PE, Wooton AM, Thompson AJ, Seymour AE, Clarkson AR: Immunologic studies in IgA nephropathy. Kidney Int 18:366–374, 1980.

    Article  PubMed  CAS  Google Scholar 

  35. Nomoto Y, Sakai H: Cold reacting antinuclear factor in sera from patients with IgA nephropathy. J Lab Clin Med 74:76–87, 1979.

    Google Scholar 

  36. Cohen RS, Russell MT, Dickey LE, Schwartz MM, Roberts JL: Properties of IgA isolated from serum of patients with IgA glomerulopathy. In: Robinson RR (ed) Proceedings of the 9th international congress on nephrology. (1984, p 274A. New York: Springer-Verlag).

    Google Scholar 

  37. Chatenoud L, Bach MA: Abnormalities of T cell subsets in glomerulonephritis and systemic lupus erythematosus. Kidney Int 20:267–274, 1981.

    Article  PubMed  CAS  Google Scholar 

  38. Bannister KM, Drew PA, Clarkson AR, Woodroffe AJ: Immunoregulation in glomerulonephritis, Henoch-Schönlein purpura and lupus nephritis. Clin Exp Immunol 53:384–390, 1983.

    PubMed  CAS  Google Scholar 

  39. Egido J, Blasco R, Sancho J, Lozano L: T cell dysfunction in IgA nephropathy: specific abnormalities in the regulation of IgA synthesis. Clin Immunol Immunopathol 26:201–212, 1983.

    Article  PubMed  CAS  Google Scholar 

  40. Nomoto Y, Sakai H, Arimori S: Increase of IgA-bearing lymphocytes in peripheral blood from patients with IgA nephropathy. Am J Clin Pathol 71:158–160, 1979.

    PubMed  CAS  Google Scholar 

  41. Sakai H, Endoh M, Tomino Y, Nomoto Y: Increase of IgA specific helper T cells in patients with IgA nephropathy. Clin Exp Immunol 50:77–82, 1982.

    PubMed  CAS  Google Scholar 

  42. Hale GM, Bannister KM, Clarkson AR, Woodroffe AJ: Immunoregulatory abnormalities in IgA nephropathy. In: Robinson RR (ed) Proceedings of the 9th international congress on nephrology. New York: Springer-Verlag, 1984, p 281A.

    Google Scholar 

  43. Sakai H, Nomoto Y, Arimori S: Decrease of IgA-specific suppressor T cell activity in patients with I nephropathy. Clin Exp Immunol 38:243–248, 1979.

    PubMed  CAS  Google Scholar 

  44. Beale MG, Nash GS, Bertovich MJ, Maermott RP: Similar disturbances in B cell activity and regulatory T cell function in Henoch-Schönlein purpura and systemic lupus erythematosus. J Immunol 128:486–491, 1982.

    PubMed  CAS  Google Scholar 

  45. Perl SI, Wilkinson A, Williams DG: IgA and IgG production by lymphocytes in IgA glomerulonephritis. Kidney Int 28:856, 1985.

    Article  Google Scholar 

  46. Egido J, Blasco R, Lozano J, Sancho J, Garcia-Hoyo R: Immunological abnormalities in the tonsils of patients with IgA nephropathy: inversion in the ratio of IgA: IgG bearing lymphocytes and increased polymeric IgA synthesis. Clin Exp Immunol 57:101–106, 1984.

    PubMed  CAS  Google Scholar 

  47. Berthoux FC, Gagne A, Sabatier JC, Ducret F, Le Petit JC, Marcellin M, Mercier B, Brizard CP: HLA-Bw35 and mesangial IgA glomerulonephritis. N Engl J Med 298:1034–1035, 1978.

    PubMed  CAS  Google Scholar 

  48. Hiki Y, Kobayashi Y, Tateno S, Sada M, Kashiwagi N: Strong association of HLA-DR4 with benign IgA nephropathy. Nephron 32:222–226, 1982.

    Article  PubMed  CAS  Google Scholar 

  49. McLean RH, Wyatt RJ, Julian BA: Complement phenotypes in glomerulonephritis: increased frequency of homozygous null C4 phenotypes in IgA nephropathy and Hencoh-Schönlein purpura. Kidney Int 26:855–860, 1984.

    Article  PubMed  CAS  Google Scholar 

  50. Egido J, Blasco R, Sancho J, Lozano L, Gutierrez-Millet V: Immunologic studies in a familial IgA nephropathy. Clin Exp Immunol 54:532–538, 1983.

    PubMed  CAS  Google Scholar 

  51. Julian BA, Quiggins PA, Thompson JS, Woodford SY, Gleason K, Wyatt RJ: Familial IgA nephropathy: evidence of an inherited mechanism of disease. N Engl J Med 312:202–208, 1985.

    Article  PubMed  CAS  Google Scholar 

  52. Galla JH, Kohaut EC, Alexander R, Mestecky J: Racial differences in the prevalence of IgA-associated nephropathies. Lancet 2:522, 1984.

    Article  PubMed  CAS  Google Scholar 

  53. Disney APS: Australian and New Zealand dialysis and transplant registry, 1984.

    Google Scholar 

  54. Hoover RG, Heikman S, Berger HM, Rebbe N, Lynch RG: Expansion of Fc receptor-bearing T lymphocytes in patients with immunoglobulin G and immunoglobulin A myeloma. J Clin Invest 67:308–311, 1981.

    Article  PubMed  CAS  Google Scholar 

  55. Nicholls K, Kincaid-Smith P: Defective in vivo Fc- and C3b-receptor function in IgA nephropathy. Am J Kidney Dis 4:128–134, 1984.

    PubMed  CAS  Google Scholar 

  56. Woodroffe AJ: IgA, glomerulonephritis and liver disease. Aust NZJ Med 11:109–111, 1981.

    Article  CAS  Google Scholar 

Download references

Authors
  1. Andrew J. Woodroffe
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Anthony R. Clarkson

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Martinus Nijhoff Publishing, Boston

About this chapter

Cite this chapter

Woodroffe, A.J. (1987). Summary of the Pathogenesis of IgA Nephropathy. In: Clarkson, A.R. (eds) IgA Nephropathy. Topics in Renal Medicine, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2039-5_14

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2039-5_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9213-5

  • Online ISBN: 978-1-4613-2039-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation