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Animal Models of IgA Nephropathy

  • Steven N. Emancipator
  • Gloria R. Gallo
  • Michael E. Lamm
Chapter
Part of the Topics in Renal Medicine book series (TIRM, volume 2)

Abstract

The traditional goal of experimental pathology is to elucidate pathogenesis and pathophysiology, thereby promoting understanding of a disease process, more accurate prognostication, and logical therapeutic intervention. While total satisfaction of these objectives is rare, even partial attainment assists in patient management and offers hope for greater future fulfillment. Limitations inherent in the study of experimental models include species differences between patients and experimental animals and the nearly inevitable variance of the model from the human disease.

Keywords

Immune Complex Bile Duct Ligation Secretory Component Mesangial Proliferation Mesangial Deposit 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Rifai A, Small PA, Teague PO, Ayoub EM: Experimental IgA nephropathy. J Exp Med 150:1161–1173, 1979.PubMedCrossRefGoogle Scholar
  2. 2.
    Isaacs K, Miller F: Antigen size and charge in immune complex glomerulonephrits. II. Passive induction of immune deposits with dextran-anti-dextran immune complexes. Am J Pathol 111:298–306, 1983.PubMedGoogle Scholar
  3. 3.
    Lamm ME: Cellular aspects of immunoglobulin A. Adv Immunol 22:223–290, 1976.PubMedCrossRefGoogle Scholar
  4. 4.
    Vaerman JP, Heremans JF: Origin and molecular size of IgA in the mesenteric lymph of the dog. Immunology 18:27–38, 1977.Google Scholar
  5. 5.
    Mostov KE, Kraehenbuhl JP, Blobel G: Receptor-mediated transcellular transport of immunoglobulin: synthesis of secretory component as multiple and larger transmembrane forms. Proc Natl Acad Sci USA 77:7257–7261, 1980.PubMedCrossRefGoogle Scholar
  6. 6.
    Isaacs K, Miller F, Lane B: Experimental model for IgA nephropathy. Clin Immunol Immunopathol 20:419–426, 1981.PubMedCrossRefGoogle Scholar
  7. 7.
    Isaacs K, Miller F: Role of antigen size and charge in immune complex glomerulonephritis. I. Active induction of disease with dextran and its derivatives. Lab Invest 47:198–204, 1982.PubMedGoogle Scholar
  8. 8.
    Emancipator SN, Gallo GR, Lamm ME: Experimental IgA nephropathy induced by oral immunization. J Exp Med 157:572–582, 1983.PubMedCrossRefGoogle Scholar
  9. 9.
    Genin C, Sabatier JC, Berthoux FC: I mesangial deposits in C3H/HeJ mice after oral immunization. Proc Eur Dial Transplant Assoc 21:703–708, 1985.Google Scholar
  10. 10.
    Imai H, Nakamoto Y, Askaura K, Miki K, Yasuda T, Miura AB: Spontaneous glomerular I deposition in d mice: an animal model of IgA nephritis, Kidney Int 27:756–761, 1985.PubMedCrossRefGoogle Scholar
  11. 11.
    Gormly AA, Smith PS, Seymour AE, Clarkson AR, Woodroffe AJ: IgA glomerular deposits in experimental cirrhosis. Am J Pathol 104:50–54, 1981.PubMedGoogle Scholar
  12. 12.
    Melvin T, Burke B, Michael AF, Kim Y: Experimental IgA nephropathy in bile duct ligated rats. Clin Immunol Immunopathol 27:369–377, 1983.PubMedCrossRefGoogle Scholar
  13. 13.
    Emancipator SN, Gallo GR, Razaboni R, Lamm ME: Experimental cholestasis promotes the deposition of glomerular IgA immune complexes. Am J Pathol 113:19–26, 1983.PubMedGoogle Scholar
  14. 14.
    Rifai A, Millard K: Glomerular deposition of immune complexes prepared with monomeric or polymeric IgA. Clin Exp Immunol 60:363–368, 1985.PubMedGoogle Scholar
  15. 15.
    Emancipator SN, Gallo GR, Lamm ME: IgA nephropathy: perspectives on pathogenesis and classification. Clin Nephrol 24:161–179, 1985.PubMedGoogle Scholar
  16. 16.
    Lomax-Smith JD, Zaborwarny LA, Howarth GS, Seymour AE, Woodroffe AJ: The immunochemical characterisation of mesangial IgA deposits. Am J Pathol 113:359–364, 1983.PubMedGoogle Scholar
  17. 17.
    Monteiro RC, Halbwachs-Mecarelli L, Berger J, Lesavre P: Characteristics of eluted IgA in primary IgA nephropathy. Contrib Nephrol 40:107–111, 1984.PubMedGoogle Scholar
  18. 18.
    Monteiro RC, Noel LH, Halbwachs-Mecarelli L, Berger J, Lesavre P: Charge and size of mesangial IgA in IgA nephropathy. Kidney Int 28:666–671, 1985.PubMedCrossRefGoogle Scholar
  19. 19.
    Pfaffenbach G, Lamm ME, Gigli I: Activation of the guinea pig alternative complement pathway by mouse IgA immune complexes. J Exp Med 155:231–246, 1982.PubMedCrossRefGoogle Scholar
  20. 20.
    Emancipator SN, Lamm ME: Nephritis associated with C3 deposition in murine IgA nephropathy: a role for classical pathway activation by codeposited IgG or IgM [abstr]? In: Robinson RR (ed) Proceedings of the 9th international congress of nephrology, 1984, p 238.Google Scholar
  21. 21.
    Whitwort A, Leibowitz S, Kennedy MC, Cameron JS, Chantler C: IgA and glomerular disease. Clin Nephrol 5:33–38, 1976.Google Scholar
  22. 22.
    Woodroffe AJ, Gormly AA, Menzie PE, Wootton AM, Thomspon AJ, Seymour AE, Clarkson AR: Immunologic studies in IgA nephropathy. Kidney Int 18:366–374, 1980.PubMedCrossRefGoogle Scholar
  23. 23.
    Rifai A, Mannik M: Clearance kinetics and fate of mouse I immune complexes prepared with monomeric or dimeric IgA. J Immunol 130:1826–1832, 1983.PubMedGoogle Scholar
  24. 24.
    Rifai, Mannik M: Clearance of circulating IgA immune complexes is mediated by a specific receptor on Kupffer cells in mice. J Exp Med 160:125–137, 1984.PubMedCrossRefGoogle Scholar
  25. 25.
    Okada M, Okamura K, Ohmura N, Kitaoka T: Clinicopathologic study of IgA nephropathy in comparison with mesangial proliferative glomerulonephritis without IgA deposits [abstr]. In: Robinson RR (ed) Proceedings of the 9th international congress of nephrology, 1984, p 117.Google Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1987

Authors and Affiliations

  • Steven N. Emancipator
    • 1
  • Gloria R. Gallo
    • 1
  • Michael E. Lamm
    • 1
  1. 1.NIH grantsU.S. Public Health Service, and The John Lowey Research Grant from the Kidney Foundation of OhioUSA

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