Skip to main content
SpringerLink
Log in

Lymphocyte Function in IgA Nephropathy

  • Chapter
IgA Nephropathy

Part of the book series: Topics in Renal Medicine ((TIRM,volume 2))

Abstract

IgA nephropathy is now an accepted disease entity that is characterized by preponderant mesangial deposition of IgA [1, 2]. An increasing body of evidence suggests that the mesangial IgA deposits are likely to be either IgA polymers or IgA-dominant immune complexes [3, 4]. These IgA seem to circulate in the blood because of a frequent recurrence of this disease after renal allotransplantation [5, 6] and a rapid disappearance of IgA deposits in a grafted kidney from a donor with unsuspected IgA nephropathy [7]. The presence of such IgA in the circulation suggests an increased synthesis of IgA in patients with IgA nephropathy. Although the mechanism of immune regulation of IgA has not been fully elucidated, rapidly accumulating evidence indicates that the interaction of B and T cells plays a key role in the regulation of IgA, an isotype known to be highly T-cell specific [8]. The discussion on the altered lymphocyte function in this chapter is limited to primary IgA nephropathy because mesangial deposits of IgA are observed in various other diseases such as alcoholic cirrhosis [9].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Berger J, Hinglais N: Les Dépôts intercapillaires d’IgA-IgG. J Urol (Paris) 74:694–695, 1968.

    CAS  Google Scholar 

  2. McCoy RC, Abramowsky CR, Tisher CC: IgA nephropathy. Am J Pathol 76:123–144, 1974.

    PubMed  CAS  Google Scholar 

  3. Digeon M, Lesavre Ph, Bach JF: Analysis of circulating IgA and detection of immune complexes in primary IgA nephropathy. Clin Exp Immunol 48:61–69, 1982.

    PubMed  Google Scholar 

  4. Woodroffe AJ, Clarkson AR, Seymour AE, Lomax-Smith JD: Mesangial IgA nephritis. Springer Semin Immunopathol 5:321–332, 1982.

    Article  PubMed  CAS  Google Scholar 

  5. Berger J, Yaneva H, Nabarra B, Barbanel C: Recurrence of mesangial deposition of IgA after renal transplantation. Kidney Int 7:232–241, 1975.

    Article  PubMed  CAS  Google Scholar 

  6. Cameron JS, Turner DR: Recurrent glomerulonephritis in allografted kidneys. Clin Nephrol 7:47–54, 1977.

    PubMed  CAS  Google Scholar 

  7. Berger J: IgA mesangial nephropathy 1968–1983. In: D’Amico G, Minetti L, Ponticelli C (eds) IgA mesangial nephropathy. Basel: S Karger, 1984 p 4.

    Google Scholar 

  8. Elson CO: T cells specific for IgA switching and for IgA B-cell differentiation. Immunol Today 4:189–190, 1983.

    Article  Google Scholar 

  9. Clarkson AR, Woodroffe AJ, Bannister KM, Lomax-Smith JD, Aarons I: The syndrome of IgA nephropathy. Clin Nephrol 21:7–14, 1984.

    PubMed  CAS  Google Scholar 

  10. André C, Berthoux FC, André F, Gillon J, Genin C, Sabatier J-C: Prevalence of IgA2 deposits in IgA nephropathies: a clue to their pathogenesis. N Engl J Med 303:1343–1346, 1980.

    Article  PubMed  Google Scholar 

  11. Conley ME, Cooper MD, Michael AF: Selective deposition of immunoglobulin A1 in immunoglobulin A nephropathy, anaphylactoid purpura nephritis, and systemic lupus erythematosus. J Clin Invest 66:1432–1436, 1980.

    Article  PubMed  CAS  Google Scholar 

  12. Tornino Y, Endoh M, Nomoto Y, Sakai H: Immunoglobulin A1 in IgA nephropathy. N Engl J Med 305:1159–1160, 1981.

    Article  Google Scholar 

  13. Valentijn RM, Radi J, Haaijman JJ, Vermeer BJ, Weening JJ, Kauffmann RH, Daha MR, Van Es LA: Circulating and mesangial secretory component-binding IgA-1 in primary IgA nephropathy. Kidney Int 26:760–766, 1984.

    Article  PubMed  CAS  Google Scholar 

  14. Vaerman JP, Heremans JF, Laurell CB: Distribution of achain subclasses in normal and pathological IgA-globulins. Immunology 14:425–432, 1968.

    PubMed  CAS  Google Scholar 

  15. Delacroix DL, Dive C, Rambaud JC, Vaerman JP: IgA subclasses in various secretions and in serum. Immunology 47:383–385, 1982.

    PubMed  CAS  Google Scholar 

  16. Komatsu N, Nagura H, Watanabe K, Nomoto Y, Kobayashi K: Mesangial deposits of J-chain linked polymeric IgA nephropathy. Nephron 33:61–64, 1983.

    Article  PubMed  CAS  Google Scholar 

  17. Tornino Y, Sakai H, Miura M, Endoh M, Nomoto Y: Detection of polymeric IgA in glomeruli from patients with IgA nephropathy. Clin Exp Immunol 49:419–425, 1982.

    Google Scholar 

  18. Bene MC, Faure G, Duheille J: IgA nephropathy: characterization of the polymeric nature of mesangial deposits by in vitro binding of free secretory component. Clin Exp Immunol 47:527–534, 1982.

    PubMed  CAS  Google Scholar 

  19. Kutteh W, Prince SJ, Mestecky J: Tissue origins of human polymeric and monomeric IgA. J Immunol 128:990–995, 1982.

    PubMed  CAS  Google Scholar 

  20. Lague G, Hirbec G, Fournel M, Intrator L: Glomérulonéphrite mesangiale à dépôts d’IgA: étude des immunoglobulins sériques. J Urol (Paris) 80:385–392, 1973.

    Google Scholar 

  21. Whitworth JA, Leibowitz S, Kennedy MC: IgA and glomerular disease. Clin Nephrol 5:33–36, 1976.

    PubMed  CAS  Google Scholar 

  22. D’Amico G: Idiopathic mesangial IgA nephropathy. In: Bertani T, Remuzzi G (eds) Glomerular injury. Milan: Wichtig Editore, 1983, pp 205–228.

    Google Scholar 

  23. Trascasa ML, Egido J, Sancho J, Hernando L: IgA glomerulonephritis (Berger’s disease): evidence of high serum levels of polymeric IgA. Clin Exp Immunol 42:247–254, 1980.

    PubMed  CAS  Google Scholar 

  24. Endoh M, Suga T, Miura M, Tornino Y, Nomoto Y, Sakai H: In vivo alteration ofantibody production in patients with IgA nephropathy. Clin Exp Immunol 57:564–570, 1984.

    PubMed  CAS  Google Scholar 

  25. Hall RP, Stachura I, Cason J, Whiteside TL, Lawley TJ: IgA-containing circulating immune complexes in patients with IgA nephropathy. Am J Med 74:56–63, 1983.

    Article  PubMed  CAS  Google Scholar 

  26. Woodroffe AJ, Gormly AA, McKenzie PE, Wootton AM, Thompson AJ, Seymour AE, Clarkson AR: Immunologic studies in IgA nephropathy. Kidney Int 18:366–374, 1980.

    Article  PubMed  CAS  Google Scholar 

  27. Coppo R, Basolo B, Martina G, Rollino C, De Marchi M, Giacchino F, Mazzucco G, Messina M, Piccoli G: Circulating immune complexes containing IgA, IgG and IgM in patients with primary IgA nephropathy and with Henoch-Schonlein nephritis. Correlation with clinical and histologic signs of activity. Clin Nephrol 18:230–239, 1982.

    PubMed  CAS  Google Scholar 

  28. Endoh M: Increase in lymphocytes with Fc receptors for IgA and rates of spontaneous IgA synthesis in patients with IgA nephropathy. Jpn J Nephrol 26:1179–1185, 1984.

    CAS  Google Scholar 

  29. Sakai H, Nomoto Y, Arimori S: Decrease of IgA-specific suppressor T cell activity in patients with IgA nephropathy. Clin Exp Immunol 38:243–248, 1979.

    PubMed  CAS  Google Scholar 

  30. Feehally J, Brenchley PE, Coupes BM, Beattie TJ, Mallick NP, Postlethwaite RJ: IgA immune system activation in IgA nephropathy during macroscopic haematuria. In: Robinson RR (ed) Proceeding of the 9th international congress on nephrology, Los Angeles, 1984, p 278A.

    Google Scholar 

  31. Egido J, Blasco R, Sancho J, Lozano L, Sanchez-Crespo M, Hernando L: Increased rates of polymeric IgA synthesis by circulating lymphoid cells in IgA mesangial glomerulonephritis. Clin Exp Immunol 47:309–316, 1982.

    PubMed  CAS  Google Scholar 

  32. Cosio FG, Lam S, Folami AO, Conley ME, Michael AF: Immune regulation of immunoglobulin production in IgA-nephropathy. Clin Immunol Immunopathol 23:430–436, 1982.

    Article  PubMed  CAS  Google Scholar 

  33. Sakai H, Endoh M, Tomino Y, Nomoto Y: Increase of IgA specific helper Tα cells in patients with IgA nephropathy. Clin Exp Immunol 50:77–82, 1982.

    PubMed  CAS  Google Scholar 

  34. Bene MC, Faure G, Hurault de Ligny B, Kessler M, Duheille J: Immunoglobulin A nephropathy: quantitative immunohistomorphometry of the tonsillar plasma cells evidences an inversion of the immunoglobulin A versus immunoglobulin G secreting cell balance. J Clin Invest 71:1342–1347, 1983.

    Article  PubMed  CAS  Google Scholar 

  35. Egido J, Blasco R, Lozano L, Sancho J, Garcia-Hoyo R: Immunological abnormalities in the tonsils of patients with IgA nephropathy: inversion in the ratio of IgA:IgG bearing lymphocytes and increased polymeric IgA synthesis. Clin Exp Immunol 57:101–106, 1984.

    PubMed  CAS  Google Scholar 

  36. Nomoto Y, Sakai H, Endoh M, Tomino Y: Scleritis and IgA nephropathy. Arch Intern Med 140:783–787, 1980.

    Article  PubMed  CAS  Google Scholar 

  37. Hurault de Ligney B, Sirbat D, Bene MC, Faure G, Kessler M: Scleritis associated with glomerulonephritis. Nephron 35:207, 1983.

    Article  Google Scholar 

  38. Bene MC, Hurault de Ligny B, Sirbat D, Faure G, Kessler M, Duheille J: IgA nephropathy: dimeric IgA-secreting cells are present in episcleral infiltrate. Am J Clin Pathol 82:608–611, 1984.

    PubMed  CAS  Google Scholar 

  39. Kuritani T, Cooper MD: Human B cell differentiation. I. Analysis of immunoglobulin heavy chain switching using monoclonal anti-immunoglobulin M, G, and A antibodies and pokeweed mitogen-induced plasma cell differentiation. J Exp Med 155:839–851, 1982.

    Article  PubMed  CAS  Google Scholar 

  40. Nomoto Y, Sakai H, Arimori S: Increase of IgA-bearing lymphocytes in peripheral blood from patients with IgA nephropathy. Am J Clin Pathol 71:158–160, 1979.

    PubMed  CAS  Google Scholar 

  41. Sakai H, Nomoto Y, Arimori S, Komori K, Inouye H, Tsuji K: Increase of IgA-bearing peripheral blood lymphocytes in families of patients with IgA nephropathy. Am J Clin Pathol 72:452–456, 1979.

    PubMed  CAS  Google Scholar 

  42. Fiorini G, Fornasieri A, Sinico R, Colasanti G, Gibelli A, Corneo R, D’Amico G: Lymphocyte populations in the peripheral blood from patients with IgA nephropathy. Nephron 31:354–357, 1982.

    Article  PubMed  CAS  Google Scholar 

  43. Strober W, Hanson LA, Swell KW (eds): Recent advances in mucosal immunity. New York: Raven, 1982, p 1.

    Google Scholar 

  44. McGheeJR, Mestecky J (eds): The secretory immune system. Ann N Y Acad Sci:1.

    Google Scholar 

  45. Egido J, Blasco R, Sancho J: Immunoregulation abnormalities in patients with IgA nephropathy. Ann N Y Acad Sci 409:817–818, 1983.

    Article  Google Scholar 

  46. Egido J, Blasco RA, Sancho J, Hernando L: Immunological abnormalities in healthy relatives of patients with IgA nephropathy. Am J Nephrol 5:14–20, 1985.

    Article  PubMed  CAS  Google Scholar 

  47. Turkoff-Rubin NE, Cosini AB, Fuiler T, Rubin RH, Colvin RB: IgA nephropathy in HLA identical siblings. Transplantation 26:430–433, 1978.

    Article  Google Scholar 

  48. Sabatier JC, Genin C, Assenat H, Colon S, Ducret F, Berthoux FC: Mesangial IgA glomerulonephritis in HLA identical brothers. Clin Nephrol 11:35–39, 1979.

    PubMed  CAS  Google Scholar 

  49. Montoliu J, Darnell A, Torras A, Ercilla G, Valles M, Revert L: Familial IgA nephropathy. Arch Intern Med 140:1374–1375, 1980.

    Article  PubMed  CAS  Google Scholar 

  50. Julian BA, Quiggins PA, Thompson JS, Woodford SY, Gleason K, Wyatt RJ: Familial IgA nephropathy: evidence of an inherited mechanism of disease. N Engl J Med 312:202–208, 1985.

    Article  PubMed  CAS  Google Scholar 

  51. Egido J, Sancho J, Blasco R, Rivera F, Hernando L: Immunopathogenetic aspects of IgA nephropathy. Adv Nephrol 12:103–137, 1983.

    CAS  Google Scholar 

  52. Nomoto Y, Miura M, Suga M, Endoh M, Tomino Y, Sakai H: Cold reacting anti-nuclear factor (ANF) in families of patients with IgA nephropathy. Clin Exp Immunol 58:63–67, 1984.

    PubMed  CAS  Google Scholar 

  53. Suga T: Enhanced IgA production in family members of patients with IgA nephropathy. Jpn J Nephrol (in press), 1986.

    Google Scholar 

  54. Moretta L, Mingari MC, Moretta A: Human T cell subpopulation in normal and pathologic conditions. Immunol Rev 45:163–193, 1979.

    Article  PubMed  CAS  Google Scholar 

  55. Reinherz EL, Schlossman SF: The differentiation and function of human T lymphocytes. Cell 19:821–827, 1980.

    Article  PubMed  CAS  Google Scholar 

  56. Chatenoud L, Bach M-A: Abnormalities of T-cell subsets in glomerulonephritis and systemic lupus erythematosus. Kidney Int 20:267–274, 1981.

    Article  PubMed  CAS  Google Scholar 

  57. Bannister KM, Drew PA, Clarkson AR, Woodroffe AJ: Immunoregulation in glomerulonephritis, Henoch-Schönlein purpura and lupus nephritis. Clin Exp Immunol 53:384–390, 1983.

    PubMed  CAS  Google Scholar 

  58. Rothschild E, Chatenoud L: T cell subset modulation of immunoglobulin production in IgA nephropathy and membranous glomerulonephritis. Kidny Int 25:557–564, 1984.

    Article  CAS  Google Scholar 

  59. Lum LG, Muchmore AV, Keren D, Decker J, Koski I, Strober W, Blaese RM: A receptor for IgA on human T lymphocytes. J Immunol 122:65–69, 1979.

    PubMed  CAS  Google Scholar 

  60. Lum LG, Benveniste E, Blaese RM: Functional properties of human T cells bearing Fc receptors for IgA. I. Mitogen responsiveness, mixed lymphocyte culture reactivity, and helper activity for B cell immunoglobulin production. J Immunol 124:702–707, 1980.

    PubMed  CAS  Google Scholar 

  61. Gupta S, Platsoucas CD, Good RA: Receptors for IgA on a subpopulation of human B lymphocytes. Proc Natl Acad Sci USA 76:4025–4028, 1979.

    Article  PubMed  CAS  Google Scholar 

  62. Gupta S, Good RA: Subpopulations of human T lymphocytes. XV. T lymphocytes with receptors for IgA(Tα), a distinct subpopulation of T lymphocytes: studies in patients with primary immunodeficiency disorders. Clin Exp Immunol 41:363–371, 1980.

    PubMed  CAS  Google Scholar 

  63. Endoh M, Sakai H, Suga T, Miura M, Tomino Y, Nomoto Y: Increase of peripheral blood B cells with Fc receptor for IgA in patients with IgA nephropathy. Scand J Immunol 17:437–441, 1983.

    Article  PubMed  CAS  Google Scholar 

  64. Fanger MW, Shen L, Pugh J, Bernier GM: Subpopulations of human peripheral granulocytes and monocytes express receptors for IgA. Proc Natl Acad Sci USA 77:3640–3644, 1980.

    Article  PubMed  CAS  Google Scholar 

  65. Hoover RG, Dieckgraefe BK, Lynch RG: T cells with Fc receptors for IgA: induction of Ta cells in vivo and in vitro by purified IgA. J Immunol 127:1560–1562, 1981.

    PubMed  CAS  Google Scholar 

  66. Yodoi J, Adachi M, Masuda T: Induction of Fcα on murine lymphocytes by IgA in vitro. J Immunol 128:888–894, 1982.

    PubMed  CAS  Google Scholar 

  67. Muller S, Hoover RG: T cells with Fc receptors in myeloma: suppression of growth and secretion of MOPC-315 by Tα cells. J Immunol 134:644–647, 1985.

    PubMed  CAS  Google Scholar 

  68. Kiyono H, Cooper MD, Kearney JF, Mosteller LM, Michalek SM, Koopman WJ, McGhee JR: Isotype specificity of helper T cell clones: Peyer’s patch Th cells preferentially collaborate with mature IgA B cells for IgA responses. J Exp Med 159:798–811, 1984.

    Article  PubMed  CAS  Google Scholar 

  69. Endoh M, Sakai H, Nomoto Y, Tomino Y, Kaneshige H: IgA-specific helper activity of Ta cells in human peripheral blood. J Immunol 127:2612–2613, 1981.

    PubMed  CAS  Google Scholar 

  70. Adachi M, Yodoi J, Masuda T, Takatsuki K, Uchino H: Altered expression of lymphocyte Fcα receptor in selective IgA deficiency and IgA nephropathy. J Immunol 131:1246–1251, 1983.

    PubMed  CAS  Google Scholar 

  71. Suga T, Endoh M, Sakai H, Miura M, Tomino Y, Nomoto Y: Ta cell subsets in human peripheral blood. J Immunol 134:1327–1329, 1985.

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. Hideto Sakai
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Anthony R. Clarkson

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Martinus Nijihoff Publishing, Boston

About this chapter

Cite this chapter

Sakai, H. (1987). Lymphocyte Function in IgA Nephropathy. In: Clarkson, A.R. (eds) IgA Nephropathy. Topics in Renal Medicine, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2039-5_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-2039-5_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9213-5

  • Online ISBN: 978-1-4613-2039-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation