Are Age-Related Changes in Receptor Activity an Expression of Altered Membrane Fluidity?
Among the various theories of aging, the membrane hypothesis of aging is particularly appealing (Sun and Sun, 1979; Grinna, 1977). Cellular membranes function in mediating and regulating active transport of substances across the cell boundary as well as serving as an important permeability barrier. Enzyme activities and receptor functions are also modulated by the lipid composition of membranes. The nature of membranes may change during aging either as a result of oxidative damage (Tappel, 1973) or from a deterioration of homeostatic mechanisms that maintain proper lipid composition (Kates and Kuksis, 1980). In vitro and in vivo manipulation of membrane lipids may thus provide a model of aging.
KeywordsCholesterol Permeability Sucrose Dopamine Serotonin
Unable to display preview. Download preview PDF.
- Bonetti, A.C., Battistella, A., Calderini, G., Teolato, S., Crews, F.T., Gaiti, A., Algeri, S., and Toffano, G. (1983) Biochemical alterations in the mechanisms of synaptic transmission in aging brain. In: Samuel, D., et al. (eds.) Aging of the brain. New York: Raven, pp. 171–181.Google Scholar
- Cimino, M., Valtini, G., Algeri, S., Curatola, G., Pezzoli, G., and Stramentinoli, G. (1984) Age-related modification of dopaminergic and beta-adrenergic receptor system: restoration to normal activity by modifying membrane fluidity with S-adenosylmethionine. Life Sci. 34:2029–2039.PubMedCrossRefGoogle Scholar
- Hershkowitz, M., Heron, D., Samuel, D., and Shinitzky, M. (1982) The modulation of protein phosphorylation and receptor binding in synaptic membranes by changes in lipid fluidity: implications for ageing. In: Gispen, W.H., and Routtenberg, A. (eds.) Progress in brain research, vol. 56. Amsterdam: Elsevier.Google Scholar
- Horrocks, L.A., Sun, G.Y., and D’Amato, R.A. (1975) Changes in brain lipids during aging. In: Ordy, J.M., and Brizzee, K.R., (eds.) Neurobiology of aging. New York: Plenum.Google Scholar
- Joseph, J.A.V, and Roth, G.S. (1983) Age-related alterations in dopaminergic mechanisms. In: Samuel, D., et al., (eds.) Aging of the brain. New York: Raven.Google Scholar
- Kates, M.J and Kuksis, A. (1980) Membrane fluidity. In: Biophysical techniques and cellular regulation. Clifton, NJ: Humana.Google Scholar
- Marcusson, J., Oreland, L., and Winblad, B. (1984) Effect of age on human brain serotonin (S-l) binding sites.Google Scholar
- Moroi, K., and Hsu, L.L. (1983) Dopamine receptors: effects of phosphatidyl choline. Trans. Am. Soc. Neurochem. 14:158.Google Scholar
- Shinitzky, M. (1984) Membrane fluidity and cellular functions. In: Shinitzky, M. (ed.) Physiology of membrane fluidity, vol. 1. Boco Raton, FL: CRC Press, pp. 1–51.Google Scholar
- Shinitzky, M., Heron, D.S., and Samuel, D. (1983) Restoration of membrane fluidity and serotonin receptors in the aged mouse brain. In: Samuel, D., et al., (eds.) Aging of the brain, New York: Raven.Google Scholar
- Sun, A.Y., and Sun G.Y. (1979) Neurochemical aspects of the membrane hypothesis of aging. Interdiscipl. Top. Gerontol. 15:34–53.Google Scholar
- Von Hungen, K., Derby, P., and Baxter, C.F. (1987) Modulation of serotonin receptors by specific phosphatidylcholines. Neurochem. Internat. (in press).Google Scholar